iPTMnet Report for Q15678 (PTPN14)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15678 / PTN14_HUMAN
Protein Name Tyrosine-protein phosphatase non-receptor type 14
Gene Name Name: PTPN14
Synonyms:PEZ,PTPD2;
Organism Homo sapiens (Human)

PRO ID PR:Q15678
DAG View
PRO Name tyrosine-protein phosphatase non-receptor type 14 (human)
Definition A tyrosine-protein phosphatase non-receptor type 14 that is encoded in the genome of human.
Short Label hPTPN14
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15678 (PTPN14) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K6 Ubiquitination PhosphoSitePlus
Y13 Phosphorylation PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
T23 Phosphorylation PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
S314 Phosphorylation HPRD   PhosphoSitePlus 19664994, 19415658, 19664995
T323 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus
Y425 Phosphorylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
Y439 Phosphorylation PhosphoSitePlus
Y445 Phosphorylation PhosphoSitePlus
T447 Phosphorylation PhosphoSitePlus
S461 Phosphorylation PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus
T474 Phosphorylation PhosphoSitePlus
Y485 Phosphorylation PhosphoSitePlus
S486 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332, 18077418
Y496 Phosphorylation PhosphoSitePlus
T497 Phosphorylation PhosphoSitePlus
Y506 Phosphorylation PhosphoSitePlus
K509 Ubiquitination PhosphoSitePlus
S512 Phosphorylation HPRD   PhosphoSitePlus 18691976
K527 Ubiquitination PhosphoSitePlus
S538 Phosphorylation PhosphoSitePlus
S578 Phosphorylation PhosphoSitePlus
T579 Phosphorylation PhosphoSitePlus
S584 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
K588 Ubiquitination PhosphoSitePlus
S591 Phosphorylation PhosphoSitePlus   UniProt 21406692
S593 Phosphorylation HPRD   PhosphoSitePlus 19413330, 19664995
S594 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...19664995, 19415658
T599 Phosphorylation PhosphoSitePlus
K601 Ubiquitination PhosphoSitePlus
S605 Phosphorylation PhosphoSitePlus
K607 Ubiquitination PhosphoSitePlus
S620 Phosphorylation PhosphoSitePlus
S642 Phosphorylation PhosphoSitePlus   UniProt 21406692
T670 Phosphorylation PhosphoSitePlus
S681 Phosphorylation PhosphoSitePlus
S683 Phosphorylation PhosphoSitePlus
Y733 Phosphorylation PhosphoSitePlus
K747 Ubiquitination PhosphoSitePlus
K757 Ubiquitination PhosphoSitePlus
S758 Phosphorylation PhosphoSitePlus
S760 Phosphorylation PhosphoSitePlus
K787 Ubiquitination PhosphoSitePlus
S790 Phosphorylation PhosphoSitePlus
T794 Phosphorylation PhosphoSitePlus
S803 Phosphorylation PhosphoSitePlus
S809 Phosphorylation HPRD   PhosphoSitePlus 19664995
T814 Phosphorylation PhosphoSitePlus
K817 Ubiquitination PhosphoSitePlus
S831 Phosphorylation PhosphoSitePlus
S839 Phosphorylation PhosphoSitePlus
S874 Phosphorylation PhosphoSitePlus
Y913 Phosphorylation PhosphoSitePlus
K920 Ubiquitination PhosphoSitePlus
K956 Ubiquitination PhosphoSitePlus
T1009 Phosphorylation PhosphoSitePlus
K1029 Ubiquitination PhosphoSitePlus
K1037 Ubiquitination PhosphoSitePlus
K1059 Ubiquitination PhosphoSitePlus
T1128 Phosphorylation PhosphoSitePlus
K1171 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K18 N18 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K274 T274 Biomuta DOID:363 / uterine cancer [ icgc ]
Y439 C439 Biomuta DOID:1319 / brain cancer [ cosmic ]
T447 A447 Biomuta DOID:4159 / skin cancer [ cosmic ]
S465 F465 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T474 A474 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S486 G486 Biomuta DOID:1319 / brain cancer [ cosmic ]
T497 S497 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
T579 A579 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T579 S579 Biomuta DOID:1324 / lung cancer [ cosmic ]
S584 R584 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S605 L605 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S620 F620 Biomuta DOID:4159 / skin cancer [ cosmic ]
S642 N642 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T670 M670 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T670 A670 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S681 A681 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S683 G683 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S683 N683 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y733 C733 Biomuta DOID:1324 / lung cancer [ cosmic ]
K747 R747 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S758 I758 Biomuta DOID:1324 / lung cancer [ cosmic ]
S809 L809 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S839 G839 Biomuta DOID:1324 / lung cancer [ cosmic ]