iPTMnet Report for Q15654 (TRIP6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15654 / TRIP6_HUMAN
Protein Name Thyroid receptor-interacting protein 6
Gene Name Name: TRIP6
Synonyms:OIP1;
Organism Homo sapiens (Human)

PRO ID PR:Q15654
DAG View
PRO Name thyroid receptor-interacting protein 6 (human)
Definition A thyroid receptor-interacting protein 6 that is encoded in the genome of human.
Short Label hTRIP6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15654 (TRIP6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R16 Methylation PhosphoSitePlus
R21 Methylation PhosphoSitePlus
R25 Methylation PhosphoSitePlus   UniProt 24129315
T27 Phosphorylation PhosphoSitePlus
R43 Methylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
Y55 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 17591779, 27134758, 15988003, ...23576104, 20547766, 20876301
Y55 Phosphorylation P12931 (SRC) PhosphoSitePlus 17591779, 23576104
R64 Methylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
R85 Methylation PhosphoSitePlus
R89 Methylation PhosphoSitePlus
S92 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231
R111 Methylation PhosphoSitePlus   UniProt 24129315
R116 Methylation PhosphoSitePlus
R120 Methylation PhosphoSitePlus
Y123 Phosphorylation PhosphoSitePlus
Y131 Phosphorylation phospho.ELM   PhosphoSitePlus 16497976
S142 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S147 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y149 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T153 O-Glycosylation GlyGen 23301498, 33214551, 32574038, ...35132862, 35254053, 34019948, 31373491, 29485866, 34229054
T153 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S156 O-Glycosylation GlyGen 23301498, 33214551, 32574038, ...35132862, 35254053, 34019948, 29485866, 34229054
Y157 Phosphorylation PhosphoSitePlus
T158 O-Glycosylation GlyGen 23301498, 33214551, 32574038, ...32938750, 34019948, 35254053, 35132862, 29485866, 34229054
T159 Phosphorylation PhosphoSitePlus
T162 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
R179 Methylation PhosphoSitePlus   UniProt 24129315
R185 Methylation PhosphoSitePlus
R186 Methylation PhosphoSitePlus   UniProt 24129315
S189 Phosphorylation PhosphoSitePlus   UniProt 23186163
S192 Phosphorylation PhosphoSitePlus
R205 Methylation PhosphoSitePlus   UniProt 24129315
R214 Methylation PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
R217 Methylation PhosphoSitePlus
K224 Methylation PhosphoSitePlus
R236 Methylation PhosphoSitePlus   UniProt 24129315
R238 Methylation PhosphoSitePlus   UniProt 24129315
S249 Phosphorylation PhosphoSitePlus   UniProt 23186163
R258 Methylation PhosphoSitePlus
K261 Methylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
Y275 Phosphorylation PhosphoSitePlus
R315 Methylation PhosphoSitePlus
Y320 Phosphorylation PhosphoSitePlus
Y332 Phosphorylation PhosphoSitePlus
T335 Phosphorylation PhosphoSitePlus
C387 Methylation IEDB 31844290
S400 Phosphorylation PhosphoSitePlus
R423 Methylation PhosphoSitePlus
S424 Phosphorylation PhosphoSitePlus
C476 S-Nitrosylation dbSNO 26338901
Site PTM Type PTM Enzyme Score Source PMID
S92 Phosphorylation HPRD 19651622, 17081983, 20068231
Y123 Phosphorylation HPRD 16497976
Y131 Phosphorylation HPRD 16497976
S142 Phosphorylation HPRD 18669648
S147 Phosphorylation HPRD 18669648
Y149 Phosphorylation HPRD 18669648
T153 Phosphorylation HPRD 18669648
T162 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R111 Q111 Biomuta DOID:5158 / pleural cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
R116 Q116 Biomuta DOID:363 / uterine cancer [ icgc ]
R120 P120 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S142 L142 Biomuta DOID:1612 / breast cancer [ icgc ] DOID:2531 / hematologic cancer [ cosmic ]
K224 I224 Biomuta DOID:3571 / liver cancer [ cosmic ]
R236 S236 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R315 C315 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R315 G315 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y320 C320 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
R423 Q423 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R423 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S424 R424 Biomuta DOID:363 / uterine cancer [ icgc ]