Protein Information

Cytoscape View

UniProt AC / UniProt ID Q15653 / IKBB_HUMAN
Protein Name NF-kappa-B inhibitor beta
Gene Name Name: NFKBIB
Organism Homo sapiens (Human)

PRO ID PR:Q15653
DAG View
PRO Name NF-kappa-B inhibitor beta (human)
Definition An NF-kappa-B inhibitor beta that is encoded in the genome of human.
Short Label hNFKBIB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q15653 (NFKBIB) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation O14920 (IKBKB) , Q15418 (RPS6KA1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 9038140, 9520401, 10514424, ...8657102, 9346484, 16822942
S23 Phosphorylation O14920 (IKBKB) , Q15418 (RPS6KA1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 9278383, 9038140, 9520401, ...10514424, 8657102, 9346484, 16822942
Y161 Phosphorylation PhosphoSitePlus   RLIMS-P 16286457
T175 Phosphorylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus   UniProt 24275569
S192 Phosphorylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
T239 Phosphorylation PhosphoSitePlus
T276 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
S313 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   RLIMS-P   UniProt 8887627, 9278383, 12732617
S315 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 8887627, 9278383, 12732617
Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation O15111 (CHUK) , O14920 (IKBKB) HPRD 8657102, 9689078
S23 Phosphorylation O15111 (CHUK) , O14920 (IKBKB) HPRD 8657102, 9689078
T239 Phosphorylation HPRD 20068231
S313 Phosphorylation HPRD 9278383
S315 Phosphorylation HPRD 9278383


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048598 (hNFKBIB/Phos:1) pS19,pS23 PRO

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S183 A183 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S313 N313 Biomuta DOID:10534 / stomach cancer [ icgc ]