iPTMnet Report Q15653 NFKBIB

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q15653 / IKBB_HUMAN
Protein Name	NF-kappa-B inhibitor beta
Gene Name	Name: NFKBIB Synonyms:IKBB,TRIP9;
Organism	Homo sapiens (Human)

PRO ID	PR:Q15653 DAG View
PRO Name	NF-kappa-B inhibitor beta (human)
Definition	An NF-kappa-B inhibitor beta that is encoded in the genome of human.
Short Label	hNFKBIB
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q15653 (NFKBIB) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S19	Phosphorylation	O14920 (IKBKB) , Q15418 (RPS6KA1)	score4	neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P UniProt	9038140, 9520401, 10514424, ...8657102, 9346484, 16822942
	S23	Phosphorylation	O14920 (IKBKB) , Q15418 (RPS6KA1)	score4	neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P UniProt	9278383, 9038140, 9520401, ...10514424, 8657102, 9346484, 16822942
	C121	Methylation		score1	IEDB	31844290
	Y161	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	16286457
	T175	Phosphorylation		score1	PhosphoSitePlus
	S183	Phosphorylation		score2	PhosphoSitePlus UniProt	24275569
	S192	Phosphorylation		score1	PhosphoSitePlus
	K235	Ubiquitination		score1	PhosphoSitePlus
	T239	Phosphorylation		score1	PhosphoSitePlus
	T276	Phosphorylation		score1	PhosphoSitePlus
	S280	Phosphorylation		score1	PhosphoSitePlus
	S308	Phosphorylation		score1	PhosphoSitePlus
	S313	Phosphorylation	P68400 (CSNK2A1)	score4	PhosphoSitePlus RLIMS-P UniProt	8887627, 9278383, 12732617
	S315	Phosphorylation	P68400 (CSNK2A1)	score4	phospho.ELM PhosphoSitePlus RLIMS-P UniProt	8887627, 9278383, 12732617

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S19	Phosphorylation	O15111 (CHUK) , O14920 (IKBKB)	score2	HPRD	8657102, 9689078
	S23	Phosphorylation	O15111 (CHUK) , O14920 (IKBKB)	score2	HPRD	8657102, 9689078
	T239	Phosphorylation		score0	HPRD	20068231
	S313	Phosphorylation		score1	HPRD	9278383
	S315	Phosphorylation		score1	HPRD	9278383

Proteoforms

	PRO ID (Short Label)	Sites	PTM Enzyme	Source	PMID
	PR:000048598 (hNFKBIB/Phos:1)	pS19,pS23		PRO

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
S183	A183	Biomuta		DOID:9256 / colorectal cancer [ cosmic, icgc ]
S313	N313	Biomuta		DOID:10534 / stomach cancer [ icgc ]