iPTMnet Report for Q15652 (JMJD1C)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15652 / JHD2C_HUMAN
Protein Name Probable JmjC domain-containing histone demethylation protein 2C
Gene Name Name: JMJD1C
Synonyms:JHDM2C,KIAA1380,TRIP8;
Organism Homo sapiens (Human)

PRO ID PR:Q15652
DAG View
PRO Name probable JmjC domain-containing histone demethylation protein 2C (human)
Definition A probable JmjC domain-containing histone demethylation protein 2C that is encoded in the genome of human.
Short Label hJMJD1C
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15652 (JMJD1C) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S284 Phosphorylation PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus   UniProt 21406692, 24275569
S319 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
Y332 Phosphorylation PhosphoSitePlus
K365 Acetylation PhosphoSitePlus
S373 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
S376 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S378 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S379 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S384 Phosphorylation PhosphoSitePlus
S430 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S501 Phosphorylation PhosphoSitePlus   UniProt 23186163
T505 Phosphorylation PhosphoSitePlus   UniProt 23186163
T528 Phosphorylation PhosphoSitePlus
T533 Phosphorylation PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus
K552 Acetylation PhosphoSitePlus
T556 Phosphorylation PhosphoSitePlus
S583 O-Glycosylation GlyGen 32938750
Y596 Phosphorylation PhosphoSitePlus
S598 Phosphorylation PhosphoSitePlus
Y599 Phosphorylation PhosphoSitePlus
S601 Phosphorylation PhosphoSitePlus   UniProt 23186163
S604 Phosphorylation PhosphoSitePlus
S617 Phosphorylation PhosphoSitePlus   UniProt 21406692
T622 Phosphorylation PhosphoSitePlus
T629 Phosphorylation PhosphoSitePlus
S630 Phosphorylation PhosphoSitePlus
S638 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18669648
S639 Phosphorylation PhosphoSitePlus   UniProt 23186163
S641 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692
T650 O-Glycosylation GlyGen 34846842, 33214551, 20068230, ...35138101, 30397120, 28657654, 30379171, 32574038, 31637018, 30059200, 21740066, 30620550, 34019948, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
T650 Phosphorylation PhosphoSitePlus
S652 O-Glycosylation GlyGen 20068230, 33214551, 35138101, ...30397120, 28657654, 30379171, 32574038, 31637018, 30059200, 21740066, 30620550, 34019948, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
S652 Phosphorylation PhosphoSitePlus   UniProt 21406692
S655 O-Glycosylation GlyGen 20068230, 33214551, 35138101, ...30397120, 28657654, 30379171, 32574038, 31637018, 30059200, 21740066, 30620550, 34019948, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
S655 Phosphorylation PhosphoSitePlus
K659 Ubiquitination PhosphoSitePlus
Y662 Phosphorylation PhosphoSitePlus
K676 Sumoylation PhosphoSitePlus
K676 Ubiquitination PhosphoSitePlus
T691 O-Glycosylation GlyGen 20068230, 33214551, 35138101, ...30397120, 28657654, 30379171, 32574038, 31637018, 30059200, 21740066, 30620550, 34019948, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
T699 O-Glycosylation GlyGen 20068230, 33214551, 35138101, ...30397120, 28657654, 30379171, 32574038, 31637018, 30059200, 21740066, 30620550, 34019948, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
K700 Ubiquitination PhosphoSitePlus
S701 Phosphorylation PhosphoSitePlus
S734 Phosphorylation PhosphoSitePlus
S742 Phosphorylation PhosphoSitePlus
S744 Phosphorylation PhosphoSitePlus
R897 Methylation PhosphoSitePlus
T912 O-Glycosylation GlyGen 20068230, 33214551, 35138101, ...30397120, 28657654, 30379171, 32574038, 31637018, 30059200, 21740066, 30620550, 34019948, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
S913 O-Glycosylation GlyGen 20068230, 33214551, 35138101, ...30397120, 28657654, 30379171, 32574038, 31637018, 30059200, 21740066, 30620550, 34019948, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
S942 Phosphorylation PhosphoSitePlus
S943 Phosphorylation PhosphoSitePlus   UniProt 23186163
K948 Ubiquitination PhosphoSitePlus
K961 Sumoylation PhosphoSitePlus
K961 Ubiquitination PhosphoSitePlus
S969 O-Glycosylation GlyGen 20068230, 33214551, 35138101, ...30397120, 28657654, 30379171, 32574038, 31637018, 30059200, 21740066, 30620550, 34019948, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
S974 Phosphorylation PhosphoSitePlus
S984 Phosphorylation PhosphoSitePlus
K988 Ubiquitination PhosphoSitePlus
K1040 Sumoylation PhosphoSitePlus
S1050 Phosphorylation PhosphoSitePlus
S1054 Phosphorylation PhosphoSitePlus
S1057 Phosphorylation PhosphoSitePlus
S1058 Phosphorylation PhosphoSitePlus
K1065 Sumoylation PhosphoSitePlus
S1073 O-Glycosylation GlyGen 20068230, 33214551, 35138101, ...30397120, 28657654, 30379171, 32574038, 31637018, 30059200, 21740066, 30620550, 34019948, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
S1083 O-Glycosylation GlyGen 20068230, 33214551, 35138101, ...30397120, 28657654, 30379171, 32574038, 31637018, 30059200, 21740066, 30620550, 34019948, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
S1087 O-Glycosylation GlyGen 20068230, 33214551, 35138101, ...30397120, 28657654, 30379171, 32574038, 32938750, 30059200, 31637018, 30620550, 34019948, 21740066, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
S1091 O-Glycosylation GlyGen 20068230, 33214551, 35138101, ...30397120, 28657654, 30379171, 32574038, 31637018, 30059200, 21740066, 30620550, 34019948, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
S1098 O-Glycosylation GlyGen 34846842
K1112 Ubiquitination PhosphoSitePlus
S1173 O-Glycosylation GlyGen 20068230, 33214551, 35138101, ...30397120, 28657654, 30379171, 32574038, 31637018, 30059200, 21740066, 30620550, 34019948, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
S1185 O-Glycosylation GlyGen 34846842, 33214551, 20068230, ...35138101, 30397120, 28657654, 30379171, 32574038, 31637018, 30059200, 21740066, 30620550, 34019948, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
S1185 Phosphorylation PhosphoSitePlus
T1187 Phosphorylation PhosphoSitePlus
T1190 O-Glycosylation GlyGen 20068230, 33214551, 35138101, ...30397120, 28657654, 30379171, 32574038, 31637018, 30059200, 21740066, 30620550, 34019948, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
S1192 O-Glycosylation GlyGen 20068230, 33214551, 35138101, ...30397120, 28657654, 30379171, 32574038, 32938750, 30059200, 31637018, 30620550, 34019948, 21740066, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
S1193 O-Glycosylation GlyGen 34846842
T1194 O-Glycosylation GlyGen 32938750
T1196 Phosphorylation PhosphoSitePlus
S1216 Phosphorylation PhosphoSitePlus
S1223 Phosphorylation PhosphoSitePlus
Y1224 Phosphorylation PhosphoSitePlus
S1228 Phosphorylation PhosphoSitePlus
T1233 Phosphorylation PhosphoSitePlus
K1265 Methylation PhosphoSitePlus
S1268 Phosphorylation PhosphoSitePlus
T1287 Phosphorylation PhosphoSitePlus
S1295 Phosphorylation PhosphoSitePlus
K1297 Acetylation PhosphoSitePlus
T1351 O-Glycosylation GlyGen 20068230, 33214551, 35138101, ...30397120, 28657654, 30379171, 32574038, 31637018, 30059200, 21740066, 30620550, 34019948, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
S1376 O-Glycosylation GlyGen 20068230, 33214551, 35138101, ...30397120, 28657654, 30379171, 32574038, 32938750, 30059200, 31637018, 30620550, 34019948, 21740066, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
S1379 O-Glycosylation GlyGen 20068230, 33214551, 35138101, ...30397120, 28657654, 30379171, 32574038, 32938750, 30059200, 31637018, 30620550, 34019948, 21740066, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
S1383 O-Glycosylation GlyGen 32938750
T1405 Phosphorylation PhosphoSitePlus
S1409 Phosphorylation PhosphoSitePlus
S1414 Phosphorylation PhosphoSitePlus
T1428 Phosphorylation PhosphoSitePlus
C1432 Methylation IEDB 31844290
S1434 Phosphorylation PhosphoSitePlus
S1437 O-Glycosylation GlyGen 34846842, 33214551, 20068230, ...35138101, 30397120, 28657654, 30379171, 32574038, 31637018, 30059200, 21740066, 30620550, 34019948, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
K1445 Acetylation PhosphoSitePlus
S1451 O-Glycosylation GlyGen 20068230, 33214551, 35138101, ...30397120, 28657654, 30379171, 32574038, 31637018, 30059200, 21740066, 30620550, 34019948, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
T1452 O-Glycosylation GlyGen   PhosphoSitePlus 20068230, 33214551, 35138101, ...30397120, 28657654, 30379171, 32574038, 31637018, 30059200, 21740066, 30620550, 34019948, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
T1453 O-Glycosylation GlyGen   PhosphoSitePlus 20068230, 33214551, 35138101, ...30397120, 28657654, 30379171, 32574038, 31637018, 30059200, 21740066, 30620550, 34019948, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
T1457 O-Glycosylation GlyGen   PhosphoSitePlus 35138101, 30620550, 31492838, ...35289036, 35254053, 22661428, 29237092, 31637018, 21158410, 30397120, 32574038, 20305658, 28657654, 34846842, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 20068230
S1460 Phosphorylation PhosphoSitePlus
S1461 Phosphorylation PhosphoSitePlus
K1486 Ubiquitination PhosphoSitePlus
T1548 Phosphorylation PhosphoSitePlus
C1582 Methylation IEDB 31844290
T1621 Phosphorylation PhosphoSitePlus
S1628 Phosphorylation PhosphoSitePlus
S1631 Phosphorylation PhosphoSitePlus
S1634 Phosphorylation PhosphoSitePlus
S1636 Phosphorylation PhosphoSitePlus
S1677 Phosphorylation PhosphoSitePlus
S1682 Phosphorylation PhosphoSitePlus
K1685 Ubiquitination PhosphoSitePlus
S1748 Phosphorylation PhosphoSitePlus
S1761 Phosphorylation PhosphoSitePlus
S1763 Phosphorylation PhosphoSitePlus
T1822 O-Glycosylation GlyGen 20068230, 33214551, 35138101, ...30397120, 28657654, 30379171, 32574038, 31637018, 30059200, 21740066, 30620550, 34019948, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
K1832 Ubiquitination PhosphoSitePlus
T1905 Phosphorylation PhosphoSitePlus
S1911 Phosphorylation PhosphoSitePlus
T1914 Phosphorylation PhosphoSitePlus
K1930 Ubiquitination PhosphoSitePlus
S1973 Phosphorylation PhosphoSitePlus
T1978 Phosphorylation PhosphoSitePlus
S1982 Phosphorylation PhosphoSitePlus
S1989 Phosphorylation PhosphoSitePlus   UniProt 21406692
S2005 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2007 Phosphorylation PhosphoSitePlus
T2031 O-Glycosylation GlyGen 20068230, 33214551, 35138101, ...30397120, 28657654, 30379171, 32574038, 31637018, 30059200, 21740066, 30620550, 34019948, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
S2045 Phosphorylation PhosphoSitePlus
S2047 Phosphorylation PhosphoSitePlus
T2052 O-Glycosylation GlyGen 20068230, 33214551, 35138101, ...30397120, 28657654, 30379171, 32574038, 31637018, 30059200, 21740066, 30620550, 34019948, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
T2052 Phosphorylation PhosphoSitePlus
S2053 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15302935
S2057 O-Glycosylation GlyGen 20068230, 33214551, 35138101, ...30397120, 28657654, 30379171, 32574038, 32938750, 30059200, 31637018, 30620550, 34019948, 21740066, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
S2057 Phosphorylation PhosphoSitePlus
S2064 Phosphorylation PhosphoSitePlus
T2065 Phosphorylation PhosphoSitePlus
T2072 O-Glycosylation GlyGen 30379171
T2073 O-Glycosylation GlyGen 20068230, 33214551, 35138101, ...30397120, 28657654, 30379171, 32574038, 31637018, 30059200, 21740066, 30620550, 34019948, 31492838, 29351928, 20305658, 35289036, 35254053, 22661428, 29237092, 21158410
K2076 Acetylation PhosphoSitePlus
K2076 Ubiquitination PhosphoSitePlus
T2082 Phosphorylation PhosphoSitePlus
K2100 Ubiquitination PhosphoSitePlus
K2183 Ubiquitination PhosphoSitePlus
K2226 Ubiquitination PhosphoSitePlus
S2228 Phosphorylation PhosphoSitePlus
S2231 Phosphorylation PhosphoSitePlus
K2236 Ubiquitination PhosphoSitePlus
K2247 Ubiquitination PhosphoSitePlus
K2260 Ubiquitination PhosphoSitePlus
K2262 Ubiquitination PhosphoSitePlus
K2271 Ubiquitination PhosphoSitePlus
K2283 Ubiquitination PhosphoSitePlus
S2284 Phosphorylation IEDB 32387766
K2296 Ubiquitination PhosphoSitePlus
K2366 Ubiquitination PhosphoSitePlus
K2397 Ubiquitination PhosphoSitePlus
R2425 Methylation PhosphoSitePlus
K2433 Ubiquitination PhosphoSitePlus
K2509 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S317 Phosphorylation HPRD 19651622
S319 Phosphorylation HPRD 19651622
S320 Phosphorylation HPRD 19651622
S373 Phosphorylation HPRD 19651622, 18669648, 18452278
S376 Phosphorylation HPRD 19651622, 18669648
S378 Phosphorylation HPRD 19651622, 18669648
S379 Phosphorylation HPRD 18669648, 18452278
S430 Phosphorylation HPRD 17525332
S617 Phosphorylation HPRD 20068231
S638 Phosphorylation HPRD 19651622, 18669648
S641 Phosphorylation HPRD 19651622, 18669648
S943 Phosphorylation HPRD 19664995
S1185 Phosphorylation HPRD 20068231
S2005 Phosphorylation HPRD 18669648
S2047 Phosphorylation HPRD 18452278
T2052 Phosphorylation HPRD 19664995
S2053 Phosphorylation HPRD 18669648, 19664994, 19664995, ...18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S317 T317 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S317 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S319 N319 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T533 K533 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S598 F598 Biomuta DOID:1612 / breast cancer [ icgc ]
S601 F601 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T622 S622 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S638 P638 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S641 L641 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T650 I650 Biomuta DOID:1324 / lung cancer [ cosmic ]
T699 A699 Biomuta DOID:1324 / lung cancer [ cosmic ]
R897 M897 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S984 L984 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S1054 L1054 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1083 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1192 Y1192 Biomuta DOID:363 / uterine cancer [ icgc ]
S1193 F1193 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1216 N1216 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1376 L1376 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
C1432 R1432 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S1451 G1451 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T1453 A1453 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1460 C1460 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1461 N1461 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K1486 N1486 Biomuta DOID:1324 / lung cancer [ cosmic ]
T1621 I1621 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T1905 A1905 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1973 F1973 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]
S2007 P2007 Biomuta DOID:4159 / skin cancer [ cosmic ]
T2052 P2052 Biomuta DOID:363 / uterine cancer [ icgc ]
S2057 P2057 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S2228 I2228 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S2231 L2231 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S2284 C2284 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
R2425 H2425 Biomuta DOID:1319 / brain cancer [ cosmic ]
R2425 C2425 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ]