Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15650 / TRIP4_HUMAN
Protein Name Activating signal cointegrator 1
Gene Name Name: TRIP4
Organism Homo sapiens (Human)

PRO ID PR:Q15650
DAG View
PRO Name activating signal cointegrator 1 (human)
Definition An activating signal cointegrator 1 that is encoded in the genome of human.
Short Label hTRIP4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15650 (TRIP4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
T69 Phosphorylation PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
Y153 Phosphorylation PhosphoSitePlus
T154 Phosphorylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
T209 Phosphorylation PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
R274 Methylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus   UniProt 23186163
S287 Phosphorylation PhosphoSitePlus
Y289 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15592455
K300 Ubiquitination PhosphoSitePlus
T327 Phosphorylation PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y345 Phosphorylation PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
Y385 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S387 Phosphorylation PhosphoSitePlus
S406 Phosphorylation HPRD 20068231
S477 Phosphorylation PhosphoSitePlus
S482 Phosphorylation PhosphoSitePlus
K523 Ubiquitination PhosphoSitePlus
K554 Ubiquitination PhosphoSitePlus
K565 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T69 N69 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T209 A209 Biomuta DOID:3571 / liver cancer [ icgc ]
S232 P232 Biomuta DOID:363 / uterine cancer [ tcga ]
R274 K274 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S276 I276 Biomuta DOID:3571 / liver cancer [ icgc ]
Y345 H345 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S371 Y371 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]