Protein Information

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UniProt AC / UniProt ID Q15648 / MED1_HUMAN
Protein Name Mediator of RNA polymerase II transcription subunit 1
Gene Name Name: MED1
Synonyms:ARC205,CRSP1,CRSP200,DRIP205,DRIP230,PBP,PPARBP,PPARGBP,RB18A,TRAP220,TRIP2;
Organism Homo sapiens (Human)

PRO ID PR:Q15648
DAG View
PRO Name mediator of RNA polymerase II transcription subunit 1 (human)
Definition A mediator of RNA polymerase II transcription subunit 1 that is encoded in the genome of human.
Short Label hMED1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15648 (MED1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K2 Methylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus
K15 Acetylation PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
S18 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
K26 Ubiquitination PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
K152 Methylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
T212 Phosphorylation PhosphoSitePlus
Y224 Phosphorylation PhosphoSitePlus
Y225 Phosphorylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
T262 Phosphorylation PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
K481 Ubiquitination PhosphoSitePlus
K496 Ubiquitination PhosphoSitePlus
S503 Phosphorylation PhosphoSitePlus
T507 Phosphorylation PhosphoSitePlus
T522 Phosphorylation PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
S588 Phosphorylation PhosphoSitePlus   UniProt 23186163
S596 Phosphorylation PhosphoSitePlus
S620 Phosphorylation PhosphoSitePlus
T628 Phosphorylation PhosphoSitePlus
S634 Phosphorylation PhosphoSitePlus
S663 Phosphorylation PhosphoSitePlus
S664 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
S671 Phosphorylation PhosphoSitePlus   RLIMS-P 28430840
S672 Phosphorylation PhosphoSitePlus
S673 Phosphorylation PhosphoSitePlus
S675 Phosphorylation PhosphoSitePlus
S682 Phosphorylation PhosphoSitePlus
S684 Phosphorylation PhosphoSitePlus
T687 Phosphorylation PhosphoSitePlus
T704 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
S719 Phosphorylation PhosphoSitePlus
S770 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S771 Phosphorylation PhosphoSitePlus
S772 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S774 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T780 Phosphorylation PhosphoSitePlus
S784 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S795 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16964243
T805 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 16964243, ...19369195, 15302935, 20068231
S816 Phosphorylation Q13315 (ATM) PhosphoSitePlus 17478428
S848 Phosphorylation PhosphoSitePlus
S850 Phosphorylation PhosphoSitePlus
S851 Phosphorylation PhosphoSitePlus
S853 Phosphorylation PhosphoSitePlus
S872 Phosphorylation Q13315 (ATM) PhosphoSitePlus 17478428
S874 Phosphorylation Q13315 (ATM) PhosphoSitePlus 17478428
S887 Phosphorylation Q13315 (ATM) PhosphoSitePlus 17478428
S900 Phosphorylation PhosphoSitePlus
T928 Phosphorylation PhosphoSitePlus
S951 Phosphorylation PhosphoSitePlus
S953 Phosphorylation Q13315 (ATM) phospho.ELM   PhosphoSitePlus 17478428, 17525332
K965 Acetylation PhosphoSitePlus
K973 Acetylation PhosphoSitePlus
K991 Acetylation PhosphoSitePlus
K994 Acetylation PhosphoSitePlus
S1000 Phosphorylation PhosphoSitePlus
K1004 Acetylation PhosphoSitePlus
K1006 Methylation PhosphoSitePlus
K1011 Acetylation PhosphoSitePlus
S1021 Phosphorylation PhosphoSitePlus
S1023 Phosphorylation PhosphoSitePlus
T1032 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) PhosphoSitePlus   RLIMS-P   Signor   UniProt 12356758, 16314496, 26743006
S1036 Phosphorylation PhosphoSitePlus
S1040 Phosphorylation PhosphoSitePlus
S1042 Phosphorylation PhosphoSitePlus
S1045 Phosphorylation PhosphoSitePlus
S1049 Phosphorylation PhosphoSitePlus
T1051 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...15302935, 18669648, 19690332
T1057 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 16964243, ...18669648, 19690332, 20068231
K1076 Acetylation PhosphoSitePlus
S1081 Phosphorylation PhosphoSitePlus
S1088 Phosphorylation PhosphoSitePlus
S1092 Phosphorylation PhosphoSitePlus
K1126 Acetylation PhosphoSitePlus
S1128 Phosphorylation PhosphoSitePlus
Y1132 Phosphorylation PhosphoSitePlus
S1133 Phosphorylation PhosphoSitePlus
S1134 Phosphorylation Q13315 (ATM) phospho.ELM   PhosphoSitePlus 17478428, 17525332
S1141 Phosphorylation Q13315 (ATM) PhosphoSitePlus 17478428
S1147 Phosphorylation Q13315 (ATM) PhosphoSitePlus 17478428
S1149 Phosphorylation PhosphoSitePlus
S1155 Phosphorylation PhosphoSitePlus
S1156 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
T1159 Phosphorylation PhosphoSitePlus
K1160 Methylation PhosphoSitePlus
K1173 Acetylation PhosphoSitePlus
K1177 Acetylation PhosphoSitePlus   UniProt 19608861
S1187 Phosphorylation PhosphoSitePlus
K1188 Acetylation PhosphoSitePlus
S1192 Phosphorylation PhosphoSitePlus
S1207 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...18847512, 18669648, 20068231
K1210 Acetylation PhosphoSitePlus
T1215 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...19369195, 18847512, 18669648, 20068231
S1218 Phosphorylation PhosphoSitePlus
S1223 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S1226 Phosphorylation PhosphoSitePlus
S1227 Phosphorylation PhosphoSitePlus
S1229 Phosphorylation PhosphoSitePlus
S1232 Phosphorylation PhosphoSitePlus
S1239 Phosphorylation PhosphoSitePlus
S1241 Phosphorylation PhosphoSitePlus
S1251 Phosphorylation PhosphoSitePlus
S1252 Phosphorylation PhosphoSitePlus
S1254 Phosphorylation PhosphoSitePlus
S1256 Phosphorylation PhosphoSitePlus
T1259 Phosphorylation PhosphoSitePlus
S1302 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1309 Acetylation PhosphoSitePlus
S1347 Phosphorylation PhosphoSitePlus   UniProt 20068231
K1354 Acetylation PhosphoSitePlus
S1368 Phosphorylation PhosphoSitePlus
K1376 Acetylation PhosphoSitePlus
T1378 Phosphorylation PhosphoSitePlus
T1387 Phosphorylation PhosphoSitePlus
S1401 Phosphorylation PhosphoSitePlus
S1403 Phosphorylation PhosphoSitePlus   UniProt 20068231
Y1431 Phosphorylation PhosphoSitePlus
S1433 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S1437 Phosphorylation PhosphoSitePlus
S1439 Phosphorylation PhosphoSitePlus
T1440 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1449 Phosphorylation PhosphoSitePlus
S1451 Phosphorylation PhosphoSitePlus
S1453 Phosphorylation PhosphoSitePlus
Y1456 Phosphorylation PhosphoSitePlus
T1457 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) , P78527 (PRKDC) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 25068892, 12356758, 16314496, ...23850489
S1463 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S1465 Phosphorylation PhosphoSitePlus
S1467 Phosphorylation PhosphoSitePlus
S1475 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y1476 Phosphorylation PhosphoSitePlus
S1479 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 19690332
S1481 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...19690332
S1482 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...17081983
K1502 Acetylation PhosphoSitePlus
K1504 Acetylation PhosphoSitePlus
K1529 Acetylation PhosphoSitePlus   UniProt 19608861
S1532 Phosphorylation PhosphoSitePlus
S1534 Phosphorylation PhosphoSitePlus
S1536 Phosphorylation PhosphoSitePlus
S1548 Phosphorylation PhosphoSitePlus
T1550 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation HPRD 15302935, 20068231
S179 Phosphorylation HPRD 20068231
S185 Phosphorylation HPRD 20068231
S446 Phosphorylation HPRD 20068231
S448 Phosphorylation HPRD 20068231
S588 Phosphorylation HPRD 20068231
T617 Phosphorylation HPRD 20068231
T623 Phosphorylation HPRD 20068231
T628 Phosphorylation HPRD 20068231
S663 Phosphorylation HPRD 18691976
S664 Phosphorylation HPRD 18691976, 18669648, 20068231
S770 Phosphorylation HPRD 18691976, 20068231, 18452278
S771 Phosphorylation HPRD 18691976, 20068231, 18452278
S772 Phosphorylation HPRD 18691976, 18452278
S774 Phosphorylation HPRD 18691976, 20068231, 18452278
T805 Phosphorylation HPRD 18691976, 15302935, 19664994, ...20068231
S951 Phosphorylation HPRD 20068231
S953 Phosphorylation HPRD 17525332
S1000 Phosphorylation HPRD 20068231
T1032 Phosphorylation HPRD 18452278
S1049 Phosphorylation HPRD 20058876
T1051 Phosphorylation HPRD 19413330, 18691976, 20058876, ...20230923, 19664994, 15302935, 18669648, 18767875, 20068231
T1057 Phosphorylation HPRD 19413330, 18691976, 18669648, ...20068231
S1134 Phosphorylation HPRD 17525332, 18077418
S1155 Phosphorylation HPRD 19651622, 18691976
S1156 Phosphorylation HPRD 19651622, 18452278
S1179 Phosphorylation HPRD 20068231
S1185 Phosphorylation HPRD 20068231
S1187 Phosphorylation HPRD 20068231
S1192 Phosphorylation HPRD 19651622, 18691976, 20068231
S1196 Phosphorylation HPRD 19651622
S1207 Phosphorylation HPRD 19413330, 18691976, 19664994, ...19651622, 18669648, 20068231
T1215 Phosphorylation HPRD 19413330, 18691976, 19664994, ...19651622, 18669648, 20068231
S1218 Phosphorylation HPRD 19651622, 20068231
S1223 Phosphorylation HPRD 19413330, 20068231, 18452278
S1226 Phosphorylation HPRD 19413330
S1227 Phosphorylation HPRD 20068231
S1238 Phosphorylation HPRD 18691976
S1252 Phosphorylation HPRD 19413330
S1347 Phosphorylation HPRD 20068231
S1366 Phosphorylation HPRD 20068231
S1368 Phosphorylation HPRD 18691976
S1401 Phosphorylation HPRD 19651622, 20068231
S1403 Phosphorylation HPRD 19651622, 18691976, 20068231
S1433 Phosphorylation HPRD 19413330, 18691976, 20068231
S1439 Phosphorylation HPRD 19413330, 20068231
T1440 Phosphorylation HPRD 19413330, 20068231
S1453 Phosphorylation HPRD 18452278
Y1456 Phosphorylation HPRD 18452278
S1463 Phosphorylation HPRD 19413330, 18669648, 18452278
S1475 Phosphorylation HPRD 18691976, 18669648, 18452278
Y1476 Phosphorylation HPRD 19413330, 18691976
S1479 Phosphorylation HPRD 19413330, 18691976, 18452278, ...19651622, 18669648, 20068231
S1481 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231, 18452278
S1482 Phosphorylation HPRD 19413330, 19651622, 18669648, ...18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K145 N145 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K202 N202 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ] DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K235 R235 Biomuta DOID:363 / uterine cancer [ tcga ]
S588 L588 Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ]
T623 P623 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T628 M628 Biomuta DOID:4362 / cervical cancer [ tcga ]
S634 L634 Biomuta DOID:1909 / melanoma [ icgc, tcga ] DOID:3070 / malignant glioma [ tcga ]
S671 F671 Biomuta DOID:1909 / melanoma [ tcga ]
S671 Y671 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S673 F673 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S682 T682 Biomuta DOID:263 / kidney cancer [ tcga ]
S682 L682 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S774 R774 Biomuta DOID:3070 / malignant glioma [ tcga ]
S816 Y816 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T928 K928 Biomuta DOID:1115 / sarcoma [ tcga ]
S1049 C1049 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
T1051 I1051 Biomuta DOID:3070 / malignant glioma [ tcga ]
S1088 Y1088 Biomuta DOID:1612 / breast cancer [ tcga ]
S1149 F1149 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S1156 F1156 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S1179 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S1192 F1192 Biomuta DOID:363 / uterine cancer [ tcga ]
T1215 N1215 Biomuta DOID:3571 / liver cancer [ icgc ]
S1218 C1218 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S1227 L1227 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S1239 L1239 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S1251 Y1251 Biomuta DOID:3571 / liver cancer [ icgc ]
S1252 L1252 Biomuta DOID:1324 / lung cancer [ tcga ]
S1254 L1254 Biomuta DOID:1324 / lung cancer [ tcga ]
S1368 F1368 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T1378 N1378 Biomuta DOID:3571 / liver cancer [ icgc ]
Y1431 C1431 Biomuta DOID:363 / uterine cancer [ tcga ]
S1437 R1437 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1439 F1439 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S1467 P1467 Biomuta DOID:4362 / cervical cancer [ tcga ]
S1475 F1475 Biomuta DOID:5041 / esophageal cancer [ tcga ]
S1479 N1479 Biomuta DOID:10534 / stomach cancer [ cosmic ]