Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15645 / PCH2_HUMAN
Protein Name Pachytene checkpoint protein 2 homolog
Gene Name Name: TRIP13
Synonyms:PCH2;
Organism Homo sapiens (Human)

PRO ID PR:Q15645
DAG View
PRO Name pachytene checkpoint protein 2 homolog (human)
Definition A thyroid receptor-interacting protein 13 that is encoded in the genome of human.
Short Label hTRIP13
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15645 (TRIP13) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22223895
K9 Sumoylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus
Y56 Phosphorylation P00533 (EGFR) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 15592455, 32860853
S74 Phosphorylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
T183 Phosphorylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
Y206 Phosphorylation PhosphoSitePlus
S216 Phosphorylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
K316 Ubiquitination PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
S384 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation HPRD 18691976, 17081983, 20068231
S147 Phosphorylation HPRD 20068231
T155 Phosphorylation HPRD 20068231
S384 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K9 R9 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S18 L18 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K81 N81 Biomuta DOID:3571 / liver cancer [ icgc ]
Y206 C206 Biomuta DOID:3070 / malignant glioma [ tcga ]
S216 I216 Biomuta DOID:3571 / liver cancer [ icgc ]
K316 R316 Biomuta DOID:3953 / adrenal gland cancer [ tcga ]