Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15637 / SF01_HUMAN
Protein Name Splicing factor 1
Gene Name Name: SF1
Synonyms:ZFM1,ZNF162;
Organism Homo sapiens (Human)

PRO ID PR:Q15637
DAG View
PRO Name splicing factor 1 (human)
Definition A splicing factor 1 that is encoded in the genome of human.
Short Label hSF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15637 (SF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895
T8 Phosphorylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus   UniProt 23186163
S20 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 10449420, 17287340
T26 Phosphorylation PhosphoSitePlus
T67 Phosphorylation PhosphoSitePlus
S80 Phosphorylation Q8TAS1 (UHMK1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 23186163, 16964243, ...23175611, 15302935, 18669648, 16420481, 17287340, 19690332, 20068231, 17081983
S82 Phosphorylation Q8TAS1 (UHMK1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 23186163, 16964243, ...23175611, 15302935, 18669648, 16420481, 17287340, 19690332, 20068231, 17081983
Y87 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 24275569
S89 Phosphorylation PhosphoSitePlus   UniProt 24275569
K174 Ubiquitination PhosphoSitePlus
K217 Acetylation PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
T232 Phosphorylation PhosphoSitePlus
T253 Phosphorylation PhosphoSitePlus
R263 Methylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
S268 Phosphorylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
T274 Phosphorylation PhosphoSitePlus
T277 Phosphorylation PhosphoSitePlus
C279 S-Nitrosylation dbSNO 26338901
S302 Phosphorylation PhosphoSitePlus
K306 Acetylation PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
Y313 Phosphorylation PhosphoSitePlus
S315 O-Glycosylation GlyGen 23301498, 27655845, 30059200, ...21740066, 29351928, 20305658, 29485866, 32119511, 28510447, 22121020, 28657654, 29237092
S328 O-Glycosylation GlyGen 23301498, 27655845, 30059200, ...21740066, 29351928, 20305658, 29485866, 32119511, 28510447, 22121020, 28657654, 29237092
S331 O-Glycosylation GlyGen 23301498, 27655845, 30059200, ...21740066, 29351928, 20305658, 29485866, 32119511, 28510447, 22121020, 28657654, 29237092
T332 O-Glycosylation GlyGen 23301498, 27655845, 30059200, ...21740066, 29351928, 20305658, 29485866, 32119511, 28510447, 22121020, 28657654, 29237092
S333 O-Glycosylation GlyGen 23301498, 27655845, 30059200, ...21740066, 29351928, 20305658, 29485866, 32119511, 28510447, 22121020, 28657654, 29237092
T337 O-Glycosylation GlyGen 23301498, 27655845, 30059200, ...21740066, 29351928, 20305658, 29485866, 32119511, 28510447, 22121020, 28657654, 29237092
T338 O-Glycosylation GlyGen 23301498, 27655845, 30059200, ...21740066, 29351928, 20305658, 29485866, 32119511, 28510447, 22121020, 28657654, 29237092
T338 Phosphorylation PhosphoSitePlus
S342 O-Glycosylation GlyGen 23301498, 27655845, 30059200, ...21740066, 29351928, 20305658, 29485866, 32119511, 28510447, 22121020, 28657654, 29237092
R345 Methylation PhosphoSitePlus
R365 Methylation PhosphoSitePlus
Y450 Phosphorylation PhosphoSitePlus
Y461 Phosphorylation PhosphoSitePlus
R462 Methylation PhosphoSitePlus
T521 O-Glycosylation GlyGen 23301498, 27655845, 30059200, ...21740066, 29351928, 20305658, 29485866, 32119511, 28510447, 22121020, 28657654, 29237092
Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation Q13976 (PRKG1) HPRD 10449420, 17287340
T67 Phosphorylation HPRD 20068231
S80 Phosphorylation HPRD 19413330, 17322306, 17287340, ...16964243, 19664994, 19664995, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231, 18212344
S82 Phosphorylation HPRD 19413330, 17322306, 17287340, ...16964243, 19664994, 19664995, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
Y87 Phosphorylation HPRD 19413330, 17287340, 17081983, ...19664995, 19651622, 18669648, 20068231
S89 Phosphorylation HPRD 19413330, 17081983, 18669648, ...20166139, 19415658, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation Q13976 (PRKG1) HPRD 10449420, 17287340
T67 Phosphorylation HPRD 20068231
S80 Phosphorylation HPRD   phospho.ELM 19413330, 17322306, 17287340, ...16964243, 19664994, 19664995, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231, 18212344
S82 Phosphorylation HPRD   phospho.ELM 19413330, 17322306, 17287340, ...16964243, 19664994, 19664995, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
Y87 Phosphorylation HPRD   phospho.ELM 19413330, 17287340, 17081983, ...19664995, 19651622, 18669648, 20068231
S89 Phosphorylation HPRD   phospho.ELM 19413330, 17081983, 18669648, ...20166139, 19415658, 20068231
R600 Methylation PhosphoSitePlus
K636 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation Q13976 (PRKG1) HPRD 10449420, 17287340
T67 Phosphorylation HPRD 20068231
S80 Phosphorylation HPRD 19413330, 17322306, 17287340, ...16964243, 19664994, 19664995, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231, 18212344
S82 Phosphorylation HPRD 19413330, 17322306, 17287340, ...16964243, 19664994, 19664995, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
Y87 Phosphorylation HPRD 19413330, 17287340, 17081983, ...19664995, 19651622, 18669648, 20068231
S89 Phosphorylation HPRD 19413330, 17081983, 18669648, ...20166139, 19415658, 20068231
S529 Phosphorylation PhosphoSitePlus
R537 Methylation PhosphoSitePlus
R545 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T8 Phosphorylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
S654 Phosphorylation PhosphoSitePlus
R662 Methylation PhosphoSitePlus
R670 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K454 Ubiquitination PhosphoSitePlus
Y455 Phosphorylation PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus
S466 Phosphorylation PhosphoSitePlus
R467 Methylation PhosphoSitePlus
Y522 Phosphorylation PhosphoSitePlus
R533 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S20 R20 Biomuta DOID:3571 / liver cancer [ icgc ]
S20 I20 Biomuta DOID:1909 / melanoma [ cosmic ]
K174 T174 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S268 L268 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S268 * Biomuta DOID:11934 / head and neck cancer [ tcga ]
T332 I332 Biomuta DOID:3963 / thyroid carcinoma [ tcga ]
R345 C345 Biomuta DOID:1324 / lung cancer [ tcga ]
Y450 * Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
R462 H462 Biomuta DOID:1909 / melanoma [ cosmic ]