iPTMnet Report for Q15637 (SF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15637 / SF01_HUMAN
Protein Name Splicing factor 1
Gene Name Name: SF1
Synonyms:ZFM1,ZNF162;
Organism Homo sapiens (Human)

PRO ID PR:Q15637
DAG View
PRO Name splicing factor 1 (human)
Definition A splicing factor 1 that is encoded in the genome of human.
Short Label hSF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15637 (SF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895
T8 Phosphorylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus   UniProt 23186163
S20 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 10449420, 17287340
T26 Phosphorylation PhosphoSitePlus
T67 Phosphorylation PhosphoSitePlus
S80 Phosphorylation Q8TAS1 (UHMK1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 17287340, 16964243, ...23175611, 15302935, 18669648, 16420481, 23186163, 19690332, 20068231, 17081983
S82 Phosphorylation Q8TAS1 (UHMK1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 17287340, 16964243, ...23175611, 15302935, 18669648, 16420481, 23186163, 19690332, 20068231, 17081983
Y87 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 24275569
S89 Phosphorylation PhosphoSitePlus   UniProt 24275569
T96 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 32870666, 35289036, 35254053, 29237092, 34725712, 32119511, 35132862, 28604694, 29485866, 20305658, 22121020, 28657654, 27655845, 33214551, 30059200, 21740066, 29351928, 34019948, 28510447, 34229054
C171 Methylation IEDB 31844290
K174 Ubiquitination PhosphoSitePlus
K217 Acetylation PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
T232 Phosphorylation PhosphoSitePlus
T253 Phosphorylation PhosphoSitePlus
R263 Methylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
S268 Phosphorylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
T274 Phosphorylation PhosphoSitePlus
T277 Phosphorylation PhosphoSitePlus
C279 S-Nitrosylation dbSNO 26338901
C292 Methylation IEDB 31844290
S302 Phosphorylation PhosphoSitePlus
K306 Acetylation PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
Y313 Phosphorylation PhosphoSitePlus
S315 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 32870666, 35289036, 35254053, 29237092, 34725712, 32119511, 35132862, 28604694, 29485866, 20305658, 22121020, 28657654, 27655845, 34846842, 33214551, 30059200, 21740066, 29351928, 34019948, 28510447, 34229054
S328 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 32870666, 35289036, 35254053, 29237092, 34725712, 32119511, 35132862, 28604694, 29485866, 20305658, 22121020, 28657654, 27655845, 33214551, 30059200, 21740066, 29351928, 34019948, 28510447, 34229054
S331 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 32870666, 35289036, 35254053, 29237092, 34725712, 32119511, 35132862, 28604694, 29485866, 20305658, 22121020, 28657654, 27655845, 33214551, 30059200, 21740066, 29351928, 34019948, 28510447, 34229054
T332 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 32870666, 35289036, 35254053, 29237092, 34725712, 32119511, 35132862, 28604694, 29485866, 20305658, 22121020, 28657654, 27655845, 33214551, 30059200, 21740066, 29351928, 34019948, 28510447, 34229054
S333 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 32870666, 35289036, 35254053, 29237092, 34725712, 32119511, 35132862, 28604694, 29485866, 20305658, 22121020, 28657654, 27655845, 33214551, 30059200, 21740066, 29351928, 34019948, 28510447, 34229054
T337 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 32870666, 35289036, 35254053, 29237092, 34725712, 32119511, 35132862, 28604694, 29485866, 20305658, 22121020, 28657654, 27655845, 33214551, 30059200, 21740066, 29351928, 34019948, 28510447, 34229054
T338 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 32870666, 35289036, 35254053, 29237092, 34725712, 32119511, 35132862, 28604694, 29485866, 20305658, 22121020, 28657654, 27655845, 33214551, 30059200, 21740066, 29351928, 34019948, 28510447, 34229054
T338 Phosphorylation PhosphoSitePlus
S342 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 32870666, 35289036, 35254053, 29237092, 34725712, 32119511, 35132862, 28604694, 29485866, 20305658, 22121020, 28657654, 27655845, 33214551, 30059200, 21740066, 29351928, 34019948, 28510447, 34229054
R345 Methylation PhosphoSitePlus
R365 Methylation PhosphoSitePlus
Y450 Phosphorylation PhosphoSitePlus
Y461 Phosphorylation PhosphoSitePlus
R462 Methylation PhosphoSitePlus
L463 Phosphorylation UniProt 18669648, 16964243, 18220336
K467 Methylation UniProt 24129315
T521 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 32870666, 35289036, 35254053, 29237092, 34725712, 32119511, 35132862, 28604694, 29485866, 20305658, 22121020, 28657654, 27655845, 33214551, 30059200, 21740066, 29351928, 34019948, 28510447, 34229054
Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation Q13976 (PRKG1) HPRD 10449420, 17287340
T67 Phosphorylation HPRD 20068231
S80 Phosphorylation HPRD 19413330, 17322306, 17287340, ...16964243, 19664994, 19664995, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231, 18212344
S82 Phosphorylation HPRD 19413330, 17322306, 17287340, ...16964243, 19664994, 19664995, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
Y87 Phosphorylation HPRD 19413330, 17287340, 17081983, ...19664995, 19651622, 18669648, 20068231
S89 Phosphorylation HPRD 19413330, 17081983, 18669648, ...20166139, 19415658, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation Q13976 (PRKG1) HPRD 10449420, 17287340
T67 Phosphorylation HPRD 20068231
S80 Phosphorylation HPRD   phospho.ELM 19413330, 17322306, 17287340, ...16964243, 19664994, 19664995, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231, 18212344
S82 Phosphorylation HPRD   phospho.ELM 19413330, 17322306, 17287340, ...16964243, 19664994, 19664995, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
Y87 Phosphorylation HPRD   phospho.ELM 19413330, 17287340, 17081983, ...19664995, 19651622, 18669648, 20068231
S89 Phosphorylation HPRD   phospho.ELM 19413330, 17081983, 18669648, ...20166139, 19415658, 20068231
R600 Methylation PhosphoSitePlus
K636 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation Q13976 (PRKG1) HPRD 10449420, 17287340
T67 Phosphorylation HPRD 20068231
S80 Phosphorylation HPRD 19413330, 17322306, 17287340, ...16964243, 19664994, 19664995, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231, 18212344
S82 Phosphorylation HPRD 19413330, 17322306, 17287340, ...16964243, 19664994, 19664995, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
Y87 Phosphorylation HPRD 19413330, 17287340, 17081983, ...19664995, 19651622, 18669648, 20068231
S89 Phosphorylation HPRD 19413330, 17081983, 18669648, ...20166139, 19415658, 20068231
S529 Phosphorylation PhosphoSitePlus
R537 Methylation PhosphoSitePlus
R545 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T8 Phosphorylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
S654 Phosphorylation PhosphoSitePlus
R662 Methylation PhosphoSitePlus
R670 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K454 Ubiquitination PhosphoSitePlus
Y455 Phosphorylation PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus
S466 Phosphorylation PhosphoSitePlus
R467 Methylation PhosphoSitePlus
Y522 Phosphorylation PhosphoSitePlus
R533 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S20 I20 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S80 F80 Biomuta DOID:4159 / skin cancer [ cosmic ]
S80 Y80 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
C171 S171 Biomuta [ cosmic ]
S268 L268 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S268 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T337 I337 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R345 C345 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic ]
Y450 * Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R462 H462 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R533 C533 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R537 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
R545 S545 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
R545 H545 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
R600 C600 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K636 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
R662 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
R670 H670 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
R670 S670 Biomuta DOID:9256 / colorectal cancer [ cosmic ]