Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15599 / NHRF2_HUMAN
Protein Name Na(+)/H(+) exchange regulatory cofactor NHE-RF2
Gene Name Name: SLC9A3R2
Synonyms:NHERF2;
Organism Homo sapiens (Human)

PRO ID PR:Q15599
DAG View
PRO Name Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (human)
Definition A Na(+)/H(+) exchange regulatory cofactor NHE-RF2 that is encoded in the genome of human.
Short Label hSLC9A3R2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15599 (SLC9A3R2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S43 Phosphorylation PhosphoSitePlus
T92 Phosphorylation PhosphoSitePlus
T102 Phosphorylation PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
S183 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K237 Ubiquitination PhosphoSitePlus
T242 Phosphorylation PhosphoSitePlus
S254 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T257 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T260 Phosphorylation PhosphoSitePlus
S261 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 26310448, 18669648
S269 Phosphorylation PhosphoSitePlus
S275 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S280 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
K282 Ubiquitination PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
S303 Phosphorylation P10398 (ARAF) PhosphoSitePlus   RLIMS-P   UniProt 26251448, 26310448, 23186163
T305 Phosphorylation PhosphoSitePlus   RLIMS-P 26251448
Site PTM Type PTM Enzyme Score Source PMID
S183 Phosphorylation HPRD 18669648
S254 Phosphorylation HPRD 18669648
T257 Phosphorylation HPRD 18669648
S261 Phosphorylation HPRD 18669648
S275 Phosphorylation HPRD 15302935
S280 Phosphorylation PhosphoSitePlus
K282 Ubiquitination PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus
T8 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q15599 (SLC9A3R2) S303 P15311 (EZR) unknown eFIP 26251448


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S141 G141 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S261 T261 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S269 F269 Biomuta DOID:363 / uterine cancer [ tcga ]
S280 F280 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K282 N282 Biomuta DOID:3571 / liver cancer [ icgc ]