iPTMnet Report for Q15554 (TERF2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15554 / TERF2_HUMAN
Protein Name Telomeric repeat-binding factor 2
Gene Name Name: TERF2
Synonyms:TRBF2,TRF2;
Organism Homo sapiens (Human)

PRO ID PR:Q15554
DAG View
PRO Name telomeric repeat-binding factor 2 (human)
Definition A telomeric repeat-binding factor 2 that is encoded in the genome of human.
Short Label hTERF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15554 (TERF2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R55 Methylation PhosphoSitePlus
R59 Methylation PhosphoSitePlus   UniProt 19596784
R60 Methylation PhosphoSitePlus   UniProt 19596784
R63 Methylation PhosphoSitePlus
R67 Methylation PhosphoSitePlus
R69 Methylation PhosphoSitePlus
R70 Methylation PhosphoSitePlus
R72 Methylation PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
T188 Phosphorylation phospho.ELM   RLIMS-P 22841872, 23307557, 16223874, ...19398584
K211 Acetylation PhosphoSitePlus
K215 Acetylation PhosphoSitePlus
T229 Phosphorylation PhosphoSitePlus
T230 Phosphorylation PhosphoSitePlus   UniProt 16223874
K232 Ubiquitination PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
K287 Sumoylation PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
R312 Methylation PhosphoSitePlus
R316 Methylation PhosphoSitePlus
T323 Phosphorylation PhosphoSitePlus
T324 Phosphorylation PhosphoSitePlus
K335 Acetylation PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
S365 Phosphorylation P24941 (CDK2) PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...18847512, 18669648, 24275569, 19690332, 20068231, 17081983
S380 Phosphorylation phospho.ELM 17525332
S410 Phosphorylation PhosphoSitePlus
T413 Phosphorylation PhosphoSitePlus
S422 Phosphorylation PhosphoSitePlus
S427 Phosphorylation PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
K444 Ubiquitination PhosphoSitePlus
S456 Phosphorylation PhosphoSitePlus
K489 Acetylation PhosphoSitePlus
K530 Acetylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O60934 (NBN) S432 Q15554 (TERF2) unknown eFIP 31825846


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T323 I323 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K489 M489 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]