Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15477 / SKIV2_HUMAN
Protein Name Helicase SKI2W
Gene Name Name: SKIV2L
Synonyms:DDX13,SKI2W,SKIV2,W;
Organism Homo sapiens (Human)

PRO ID PR:Q15477
DAG View
PRO Name helicase SKI2W (human)
Definition A helicase SKI2W that is encoded in the genome of human.
Short Label hSKIV2L
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15477 (SKIV2L) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T4 Phosphorylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
T185 Phosphorylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
S243 Phosphorylation HPRD   PhosphoSitePlus 17322306, 15345747
S245 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 16964243, ...18691976, 19664994, 15302935, 19664995, 19691289, 17322306, 18669648, 19415658, 20068231
C247 S-Nitrosylation dbSNO 26338901
S248 Phosphorylation PhosphoSitePlus
S255 Phosphorylation HPRD   PhosphoSitePlus 20058876, 19664995, 20068231
S256 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18578522, 19664994, 18707149, ...18691976, 21406692, 23186163, 18212344, 19691289, 18452278, 24275569, 19413330, 18088087, 18767875, 20058876, 19651622, 17081983, 15302935, 19664995, 17322306, 18669648, 19415658, 20068231
S270 Phosphorylation PhosphoSitePlus
T271 Phosphorylation PhosphoSitePlus
K316 Ubiquitination PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
Y358 Phosphorylation PhosphoSitePlus
T359 Phosphorylation PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
S366 Phosphorylation HPRD   phospho.ELM 17081983
K369 Ubiquitination PhosphoSitePlus
Y476 Phosphorylation PhosphoSitePlus
K516 Ubiquitination PhosphoSitePlus
Y518 Phosphorylation PhosphoSitePlus
Y519 Phosphorylation PhosphoSitePlus
K525 Ubiquitination PhosphoSitePlus
S530 Phosphorylation HPRD   PhosphoSitePlus 20068231
K531 Ubiquitination PhosphoSitePlus
K539 Ubiquitination PhosphoSitePlus
T573 Phosphorylation PhosphoSitePlus
S575 Phosphorylation PhosphoSitePlus
K597 Ubiquitination PhosphoSitePlus
S637 Phosphorylation PhosphoSitePlus
K683 Acetylation PhosphoSitePlus
K720 Ubiquitination PhosphoSitePlus
K736 Ubiquitination PhosphoSitePlus
K767 Ubiquitination PhosphoSitePlus
S775 Phosphorylation PhosphoSitePlus
K777 Ubiquitination PhosphoSitePlus
S779 Phosphorylation PhosphoSitePlus
K780 Ubiquitination PhosphoSitePlus
K791 Ubiquitination PhosphoSitePlus
K837 Ubiquitination PhosphoSitePlus
K879 Ubiquitination PhosphoSitePlus
Y897 Phosphorylation PhosphoSitePlus
K905 Ubiquitination PhosphoSitePlus
K919 Ubiquitination PhosphoSitePlus
T930 Phosphorylation HPRD   PhosphoSitePlus 19413330
K931 Ubiquitination PhosphoSitePlus
K939 Ubiquitination PhosphoSitePlus
K946 Ubiquitination PhosphoSitePlus
K991 Ubiquitination PhosphoSitePlus
K1004 Ubiquitination PhosphoSitePlus
S1017 Phosphorylation PhosphoSitePlus
K1026 Ubiquitination PhosphoSitePlus
K1035 Ubiquitination PhosphoSitePlus
K1075 Ubiquitination PhosphoSitePlus
K1225 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S256 N256 Biomuta DOID:363 / uterine cancer [ tcga ]
K369 N369 Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ] DOID:10283 / prostate cancer [ cosmic ]
S637 N637 Biomuta DOID:263 / kidney cancer [ tcga ]
S779 N779 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K791 N791 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K946 N946 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]