Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15459 / SF3A1_HUMAN
Protein Name Splicing factor 3A subunit 1
Gene Name Name: SF3A1
Synonyms:SAP114;
Organism Homo sapiens (Human)

PRO ID PR:Q15459
DAG View
PRO Name splicing factor 3A subunit 1 (human)
Definition A splicing factor 3 subunit 1 that is encoded in the genome of human.
Short Label hSF3A1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15459 (SF3A1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T17 Phosphorylation PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
K55 Acetylation PhosphoSitePlus   UniProt 19608861
K55 Ubiquitination PhosphoSitePlus
R70 Methylation PhosphoSitePlus
K80 Acetylation PhosphoSitePlus
K80 Sumoylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
Y90 Phosphorylation PhosphoSitePlus
Y93 Phosphorylation PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
T124 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
K131 Acetylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
R176 Methylation PhosphoSitePlus
T183 Phosphorylation PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
K223 Acetylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
Y245 Phosphorylation PhosphoSitePlus
K251 Acetylation PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
S320 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 19690332
S329 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18318008, 19367720, 18669648, 24275569, 17287340, 19690332, 20068231
S344 Phosphorylation PhosphoSitePlus
S359 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 17287340, 19690332, 20068231
T383 Phosphorylation PhosphoSitePlus
K399 Ubiquitination PhosphoSitePlus
Y410 Phosphorylation PhosphoSitePlus
S413 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
T416 Phosphorylation PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
K424 Acetylation PhosphoSitePlus
K424 Sumoylation PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
S451 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
Y456 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455
K467 Ubiquitination PhosphoSitePlus
T474 Phosphorylation PhosphoSitePlus
K486 Acetylation PhosphoSitePlus
K486 Ubiquitination PhosphoSitePlus
K495 Acetylation PhosphoSitePlus
K499 Acetylation PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus   UniProt 23186163
K531 Ubiquitination PhosphoSitePlus
K542 Sumoylation PhosphoSitePlus
R578 Methylation PhosphoSitePlus
R587 Methylation PhosphoSitePlus
R599 Methylation PhosphoSitePlus
S604 Phosphorylation PhosphoSitePlus
R607 Methylation PhosphoSitePlus
K686 Sumoylation PhosphoSitePlus
K702 Ubiquitination PhosphoSitePlus
K708 Ubiquitination PhosphoSitePlus
T718 Phosphorylation PhosphoSitePlus
K743 Ubiquitination PhosphoSitePlus
K754 Ubiquitination PhosphoSitePlus
K756 Acetylation PhosphoSitePlus
Y759 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455
Site PTM Type PTM Enzyme Score Source PMID
T124 Phosphorylation HPRD 17525332
S320 Phosphorylation HPRD 19651622
S329 Phosphorylation HPRD 19413330, 17322306, 17287340, ...19664995, 18452278, 19651622, 18669648, 18707149, 20166139, 19415658, 20068231
S359 Phosphorylation HPRD 19413330, 17287340, 19664994, ...15302935, 18452278, 19651622, 20058876, 20068231
S413 Phosphorylation HPRD 19413330, 18669648, 20068231
S451 Phosphorylation HPRD 19651622, 18669648, 20068231
Y456 Phosphorylation HPRD 15592455
S690 Phosphorylation HPRD 20068231
Y759 Phosphorylation HPRD 15592455


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R70 M70 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S110 P110 Biomuta DOID:11054 / urinary bladder cancer [ icgc ]
Y410 C410 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S413 P413 Biomuta DOID:4159 / skin cancer [ icgc ]
K419 T419 Biomuta DOID:1612 / breast cancer [ cosmic ]
K499 N499 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:3070 / malignant glioma [ tcga ]
R578 Q578 Biomuta DOID:363 / uterine cancer [ tcga ]
R587 C587 Biomuta DOID:363 / uterine cancer [ tcga ]
R587 H587 Biomuta DOID:1909 / melanoma [ cosmic ]
R599 W599 Biomuta DOID:2531 / hematologic cancer [ icgc ]
R599 Q599 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K756 R756 Biomuta DOID:2394 / ovarian cancer [ tcga ]
Y759 C759 Biomuta DOID:363 / uterine cancer [ tcga ]