iPTMnet Report for Q15424 (SAFB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15424 / SAFB1_HUMAN
Protein Name Scaffold attachment factor B1
Gene Name Name: SAFB
Synonyms:HAP,HET,SAFB1;
Organism Homo sapiens (Human)

PRO ID PR:Q15424
DAG View
PRO Name scaffold attachment factor B1 (human)
Definition A scaffold attachment factor B1 that is encoded in the genome of human.
Short Label hSAFB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15424 (SAFB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 21406692, 22223895, ...22814378, 20068231
T4 Phosphorylation PhosphoSitePlus
S6 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus
S20 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S21 Phosphorylation phospho.ELM 17081983
S23 Phosphorylation phospho.ELM 17081983
S24 Phosphorylation PhosphoSitePlus
T26 Phosphorylation PhosphoSitePlus
R29 Methylation PhosphoSitePlus
S32 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
R35 Methylation PhosphoSitePlus
S55 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
R60 Methylation PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus   UniProt 23186163
K83 Acetylation PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
K84 Acetylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
K172 Sumoylation PhosphoSitePlus
T188 Phosphorylation PhosphoSitePlus   UniProt 24275569
T194 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S195 Phosphorylation PhosphoSitePlus   UniProt 24275569
S196 Phosphorylation PhosphoSitePlus
S197 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
T200 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S209 Phosphorylation PhosphoSitePlus
K226 Methylation PhosphoSitePlus
K226 Sumoylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
K231 Sumoylation PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
S234 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S235 Phosphorylation PhosphoSitePlus
T245 Phosphorylation PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
K253 Sumoylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
S275 Phosphorylation PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
S288 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15302935, 16964243
K294 Acetylation PhosphoSitePlus
K294 Sumoylation PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
S321 Phosphorylation PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
S331 Phosphorylation PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
T340 Phosphorylation PhosphoSitePlus
S344 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983, 18220336
S350 Phosphorylation PhosphoSitePlus
K356 Acetylation PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
S373 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T374 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus
K381 Sumoylation PhosphoSitePlus
S383 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231
S384 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 20068231
S389 Phosphorylation PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
S395 Phosphorylation PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus   UniProt 20068231
T416 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
K423 Acetylation PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
K428 Acetylation PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
K436 Acetylation PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
T439 Phosphorylation PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus
T453 Phosphorylation PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
K475 Acetylation PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
S492 Phosphorylation PhosphoSitePlus
K500 Acetylation PhosphoSitePlus
K501 Acetylation PhosphoSitePlus
S504 Phosphorylation PhosphoSitePlus
S507 Phosphorylation PhosphoSitePlus
R509 Methylation PhosphoSitePlus
K543 Sumoylation PhosphoSitePlus
S555 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340, 17081983
S557 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
T560 Phosphorylation PhosphoSitePlus
T563 Phosphorylation PhosphoSitePlus
K568 Acetylation PhosphoSitePlus
S569 Phosphorylation PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus
K578 Sumoylation PhosphoSitePlus
T579 Phosphorylation PhosphoSitePlus
S580 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S582 Phosphorylation PhosphoSitePlus   UniProt 20068231
S587 Phosphorylation PhosphoSitePlus
S589 Phosphorylation phospho.ELM 17081983
S601 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...15302935, 18669648, 20068231
S604 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...15302935, 27920218, 18669648, 24275569, 17924679, 20068231, 17081983
K607 Acetylation PhosphoSitePlus   UniProt 19608861
K607 Ubiquitination PhosphoSitePlus
K609 Acetylation PhosphoSitePlus
S614 Phosphorylation PhosphoSitePlus
S617 Phosphorylation PhosphoSitePlus
S621 Phosphorylation phospho.ELM 17081983
S627 Phosphorylation PhosphoSitePlus
R712 Methylation PhosphoSitePlus
Y714 Phosphorylation PhosphoSitePlus
Y723 Phosphorylation PhosphoSitePlus
K728 Methylation PhosphoSitePlus
Y736 Phosphorylation PhosphoSitePlus
S738 Phosphorylation PhosphoSitePlus
R754 Methylation PhosphoSitePlus
S761 Phosphorylation PhosphoSitePlus
R764 Methylation PhosphoSitePlus
S770 Phosphorylation PhosphoSitePlus
Y780 Phosphorylation PhosphoSitePlus
R783 Methylation PhosphoSitePlus
S794 Phosphorylation PhosphoSitePlus
Y801 Phosphorylation PhosphoSitePlus
S803 Phosphorylation PhosphoSitePlus
K805 Acetylation PhosphoSitePlus
K805 Methylation PhosphoSitePlus
S808 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
R811 Methylation PhosphoSitePlus   UniProt 24129315
R818 Methylation PhosphoSitePlus
S832 Phosphorylation PhosphoSitePlus
R854 Methylation PhosphoSitePlus
S855 Phosphorylation PhosphoSitePlus
R868 Methylation PhosphoSitePlus   UniProt 24129315
R874 Methylation PhosphoSitePlus   UniProt 24129315
R884 Methylation PhosphoSitePlus   UniProt 24129315
R902 Methylation PhosphoSitePlus
S904 Phosphorylation PhosphoSitePlus
R905 Methylation PhosphoSitePlus
S907 Phosphorylation PhosphoSitePlus
R910 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T4 Phosphorylation HPRD 17081983, 19664995
S6 Phosphorylation HPRD 19664995
S11 Phosphorylation HPRD 17081983, 20068231
S20 Phosphorylation HPRD 20058876, 17081983
S21 Phosphorylation HPRD 17081983
S23 Phosphorylation HPRD 19651622, 17081983
S24 Phosphorylation HPRD 17081983, 20068231
T26 Phosphorylation HPRD 17081983
T28 Phosphorylation HPRD 17081983
S32 Phosphorylation HPRD 20068231
S55 Phosphorylation HPRD 18669648
T194 Phosphorylation HPRD 19413330, 18452278
S195 Phosphorylation HPRD 17081983
S196 Phosphorylation HPRD 17081983, 18452278
S197 Phosphorylation HPRD 18669648, 18452278, 19664995, ...17081983
T200 Phosphorylation HPRD 18669648, 17081983
S234 Phosphorylation HPRD 18452278
S235 Phosphorylation HPRD 18452278
T245 Phosphorylation HPRD 18452278
S246 Phosphorylation HPRD 18452278
S247 Phosphorylation HPRD 18452278
S288 Phosphorylation HPRD 19413330, 15302935, 19664994
S331 Phosphorylation HPRD 18452278
S332 Phosphorylation HPRD 18452278
S344 Phosphorylation HPRD 20058876, 19664995, 18452278
S373 Phosphorylation HPRD 18669648
S383 Phosphorylation HPRD 19413330, 19664995, 19651622, ...18669648, 19415658, 20068231
S384 Phosphorylation HPRD 19413330, 17081983, 19651622, ...18669648, 19415658, 20068231
S389 Phosphorylation HPRD 20068231
S395 Phosphorylation HPRD 20068231
S415 Phosphorylation HPRD 20068231
T416 Phosphorylation HPRD 15302935, 20068231
S504 Phosphorylation HPRD 18510355
S507 Phosphorylation HPRD 18510355
S555 Phosphorylation HPRD 17287340, 20068231
S557 Phosphorylation HPRD 17287340, 17081983, 20068231
T560 Phosphorylation HPRD 17081983
S576 Phosphorylation HPRD 20068231
T579 Phosphorylation HPRD 20068231
S580 Phosphorylation HPRD 20068231
S582 Phosphorylation HPRD 20068231
S589 Phosphorylation HPRD 17081983, 20068231
S601 Phosphorylation HPRD 19651622, 18669648, 15302935, ...20068231
S604 Phosphorylation HPRD 16964243, 18212344, 15302935, ...19664995, 18452278, 19651622, 18669648, 18707149, 20068231, 17924679
S617 Phosphorylation HPRD 17081983
S619 Phosphorylation HPRD 17081983
S621 Phosphorylation HPRD 17081983, 20068231
S808 Phosphorylation HPRD 17081983, 20068231
Site PTM Type PTM Enzyme Score Source PMID
R742 Methylation PhosphoSitePlus
R749 Methylation PhosphoSitePlus
R751 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
R811 Methylation PhosphoSitePlus
R818 Methylation PhosphoSitePlus
R820 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S21 P21 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T26 I26 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S79 C79 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S79 F79 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S196 L196 Biomuta DOID:4159 / skin cancer [ cosmic ]
S209 F209 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K381 T381 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S389 L389 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S414 C414 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S415 T415 Biomuta DOID:1324 / lung cancer [ cosmic ]
S415 Y415 Biomuta DOID:363 / uterine cancer [ icgc ]
K423 N423 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K428 R428 Biomuta DOID:1612 / breast cancer [ icgc ]
K431 N431 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T439 I439 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T453 M453 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K475 N475 Biomuta DOID:1324 / lung cancer [ cosmic ]
S492 Y492 Biomuta DOID:4159 / skin cancer [ cosmic ]
S569 F569 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T579 M579 Biomuta DOID:363 / uterine cancer [ icgc ]
S604 F604 Biomuta DOID:4159 / skin cancer [ cosmic ]
S604 T604 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S604 Y604 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K607 E607 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K607 N607 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K609 E609 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S617 L617 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S621 G621 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y714 N714 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y723 * Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
Y736 C736 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y736 H736 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
R764 S764 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S770 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R783 H783 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R783 C783 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S803 F803 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R868 Q868 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
R874 C874 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R874 H874 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R884 Q884 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R902 Q902 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
R910 S910 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
R910 H910 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]