iPTMnet Report Q15418 RPS6KA1

Protein Information

UniProt AC / UniProt ID	Q15418 / KS6A1_HUMAN
Protein Name	Ribosomal protein S6 kinase alpha-1
Gene Name	Name: RPS6KA1 Synonyms:MAPKAPK1A,RSK1;
Organism	Homo sapiens (Human)

PRO ID	PR:Q15418 DAG View
PRO Name	ribosomal protein S6 kinase alpha-1 (human)
Definition	A ribosomal protein S6 kinase alpha-1 that is encoded in the genome of human.
Short Label	hRPS6KA1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q15418 (RPS6KA1) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S45 T47 K51 S54 K56 K66 S72 K75 K81 Y91 K94 K110 Y138 S154 K189 S209 K210 Y220 S221 T225 Y228 T272 K278 S307 K316 K335 T359 S363 S369 S380 T384 K392 S402 K410 K421 K433 K438 K453 Y466 T474 K476 Y486 T489 K500 K505 S513 T522 K537 K562 T573 Y576 T577 K587 K633 S637 K649 K654 K667 K678 K680 S684 S687 T701 Y702 S703 K709 S732 T733 T734	PTM Type Select all Acetylation O-Glycosylation Phosphorylation Sumoylation Ubiquitination	PTM Enzyme	Score Select all 0 1 2 4	Source Select all GlyGen IEDB IntAct PRO PhosphoSitePlus RLIMS-P Signor UniProt neXtProt phospho.ELM	PMID
S45	Phosphorylation		score2	IEDB PhosphoSitePlus	27920218
T47	Phosphorylation		score0	RLIMS-P	21273600
K51	Ubiquitination		score1	PhosphoSitePlus
S54	Phosphorylation		score2	PhosphoSitePlus UniProt	19369195
K56	Ubiquitination		score1	PhosphoSitePlus
K66	Ubiquitination		score1	PhosphoSitePlus
S72	Phosphorylation		score1	PhosphoSitePlus
K75	Acetylation		score1	PhosphoSitePlus
K75	Ubiquitination		score1	PhosphoSitePlus
K81	Ubiquitination		score1	PhosphoSitePlus
Y91	Phosphorylation		score1	PhosphoSitePlus
K94	Ubiquitination		score1	PhosphoSitePlus
K110	Sumoylation		score1	PhosphoSitePlus
Y138	Phosphorylation		score1	PhosphoSitePlus
S154	Phosphorylation		score0	RLIMS-P	12618428
K189	Ubiquitination		score1	PhosphoSitePlus
S209	Phosphorylation		score1	PhosphoSitePlus
K210	Ubiquitination		score1	PhosphoSitePlus
Y220	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S221	Phosphorylation	Q15418 (RPS6KA1) , O15530 (PDPK1)	score4	neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	20957203, 16458888, 22130794, ...17192257, 9430688, 10480933, 20048145, 33260349, 7642538
T225	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648, 17192257
Y228	Phosphorylation		score1	PhosphoSitePlus
T272	O-Glycosylation		score1	GlyGen	23301498, 30379171, 33214551, ...30059200, 35254053
K278	Ubiquitination		score1	PhosphoSitePlus
S307	Phosphorylation		score2	PhosphoSitePlus UniProt	19369195
K316	Ubiquitination		score1	PhosphoSitePlus
K335	Sumoylation		score1	PhosphoSitePlus
T359	Phosphorylation		score4	phospho.ELM PRO PhosphoSitePlus RLIMS-P UniProt	18691976, 21406692, 23186163, ...17081983, 19171933, 19369195, 19371592, 17192257, 9430688, 28646679, 24277696, 18669648, 26580203
S363	Phosphorylation		score4	phospho.ELM PRO PhosphoSitePlus RLIMS-P UniProt	18691976, 21406692, 23186163, ...17081983, 19171933, 19369195, 19371592, 12618428, 17192257, 9430688, 28646679, 24277696, 18669648, 26580203, 24275569
S369	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	19369195, 18669648, 23186163, ...17192257
S380	Phosphorylation	P49137 (MAPKAPK2) , P41279 (MAP3K8) , Q13237 (PRKG2) , Q15418 (RPS6KA1)	score4	IntAct neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P UniProt	12618428, 17192257, 22216126, ...18691976, 23186163, 29652799, 16458888, 9430688, 29594152, 24275569, 29615689, 26862730, 18551195, 32605013, 26580203, 19804365, 20957203, 19369195, 25513777, 17906627, 18669648, 20068231, 25579842
T384	Phosphorylation		score1	PhosphoSitePlus
K392	Ubiquitination		score1	PhosphoSitePlus
S402	Phosphorylation		score1	PhosphoSitePlus
K410	Ubiquitination		score1	PhosphoSitePlus
K421	Sumoylation		score1	PhosphoSitePlus
K421	Ubiquitination		score1	PhosphoSitePlus
K433	Ubiquitination		score1	PhosphoSitePlus
K438	Ubiquitination		score1	PhosphoSitePlus
K453	Ubiquitination		score1	PhosphoSitePlus
Y466	Phosphorylation		score1	PhosphoSitePlus
T474	Phosphorylation		score1	PhosphoSitePlus
K476	Ubiquitination		score1	PhosphoSitePlus
Y486	Phosphorylation		score1	PhosphoSitePlus
T489	Phosphorylation		score1	PhosphoSitePlus
K500	Ubiquitination		score1	PhosphoSitePlus
K505	Ubiquitination		score1	PhosphoSitePlus
S513	Phosphorylation		score1	PhosphoSitePlus
T522	Phosphorylation		score1	PhosphoSitePlus
K537	Ubiquitination		score1	PhosphoSitePlus
K562	Ubiquitination		score1	PhosphoSitePlus
T573	Phosphorylation	P28482 (MAPK1)	score4	phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	32637030, 25730857, 16458888, ...22130794, 22357623, 9430688, 18669648, 9687510, 7642538
Y576	Phosphorylation		score1	PhosphoSitePlus
T577	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
K587	Ubiquitination		score1	PhosphoSitePlus
K633	Ubiquitination		score1	PhosphoSitePlus
S637	Phosphorylation		score1	PhosphoSitePlus
K649	Ubiquitination		score1	PhosphoSitePlus
K654	Ubiquitination		score1	PhosphoSitePlus
K667	Ubiquitination		score1	PhosphoSitePlus
K678	Ubiquitination		score1	PhosphoSitePlus
K680	Ubiquitination		score1	PhosphoSitePlus
S684	Phosphorylation		score1	PhosphoSitePlus
S687	Phosphorylation		score1	PhosphoSitePlus
T701	Phosphorylation		score1	PhosphoSitePlus
Y702	Phosphorylation		score1	PhosphoSitePlus
S703	Phosphorylation		score1	PhosphoSitePlus
K709	Ubiquitination		score1	PhosphoSitePlus
S732	Phosphorylation		score4	phospho.ELM PRO PhosphoSitePlus RLIMS-P UniProt	16083285, 19808666, 22130794, ...9430688, 18669648
T733	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
T734	O-Glycosylation		score1	GlyGen	23301498, 30379171, 33214551, ...30059200, 35254053
T734	Phosphorylation		score1	PhosphoSitePlus

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position T25 S154 Y220 S221 T225 Y228 T359 S363 S369 S380 T573 Y576 T577 S732 T733	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 0 1 2	Source Select all HPRD	PMID
T25	Phosphorylation		score0	HPRD	18691976
S154	Phosphorylation		score1	HPRD	12618428
Y220	Phosphorylation		score0	HPRD	18691976, 20068231
S221	Phosphorylation	O15530 (PDPK1)	score2	HPRD	10480933, 18767875, 20058876, ...9430688
T225	Phosphorylation	Q15418 (RPS6KA1)	score0	HPRD	17192257, 20068231
Y228	Phosphorylation		score0	HPRD	20068231
T359	Phosphorylation	P28482 (MAPK1)	score2	HPRD	18691976, 18212344, 9430688, ...19651622, 18669648, 20068231
S363	Phosphorylation	P28482 (MAPK1)	score2	HPRD	18691976, 12618428, 9430688, ...19651622, 18669648, 20068231
S369	Phosphorylation		score0	HPRD	19651622, 18691976, 18669648, ...18212344, 20068231
S380	Phosphorylation	Q15418 (RPS6KA1)	score2	HPRD	18691976, 12618428, 9430688, ...19651622, 18669648, 20068231, 10648825
T573	Phosphorylation		score2	HPRD	18691976, 18669648, 9430688
Y576	Phosphorylation		score0	HPRD	18691976
T577	Phosphorylation	Q15418 (RPS6KA1)	score0	HPRD	18669648, 17192257
S732	Phosphorylation		score2	HPRD	18691976, 18669648, 20068231, ...9430688
T733	Phosphorylation		score0	HPRD	18669648, 20068231

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position R21 S28 T30 S31 S163 Y229 S230 T234 Y237 T368 S372 S378 S389 T582 Y585 T586 S741 T742	PTM Type Select all Methylation Phosphorylation	PTM Enzyme	Score Select all 0 1 2	Source Select all HPRD PhosphoSitePlus	PMID
R21	Methylation		score1	PhosphoSitePlus
S28	Phosphorylation		score1	PhosphoSitePlus
T30	Phosphorylation		score1	PhosphoSitePlus
S31	Phosphorylation		score1	PhosphoSitePlus
S163	Phosphorylation		score1	HPRD	12618428
Y229	Phosphorylation		score0	HPRD	18691976, 20068231
S230	Phosphorylation	O15530 (PDPK1)	score2	HPRD	10480933, 18767875, 20058876, ...9430688
T234	Phosphorylation	Q15418 (RPS6KA1)	score0	HPRD	17192257, 20068231
Y237	Phosphorylation		score0	HPRD	20068231
T368	Phosphorylation	P28482 (MAPK1)	score2	HPRD	18691976, 18212344, 9430688, ...19651622, 18669648, 20068231
S372	Phosphorylation	P28482 (MAPK1)	score2	HPRD	18691976, 12618428, 9430688, ...19651622, 18669648, 20068231
S378	Phosphorylation		score0	HPRD	19651622, 18691976, 18669648, ...18212344, 20068231
S389	Phosphorylation	Q15418 (RPS6KA1)	score2	HPRD	18691976, 12618428, 9430688, ...19651622, 18669648, 20068231, 10648825
T582	Phosphorylation		score2	HPRD	18691976, 18669648, 9430688
Y585	Phosphorylation		score0	HPRD	18691976
T586	Phosphorylation	Q15418 (RPS6KA1)	score0	HPRD	18669648, 17192257
S741	Phosphorylation		score2	HPRD	18691976, 18669648, 20068231, ...9430688
T742	Phosphorylation		score0	HPRD	18669648, 20068231

Q15418 (RPS6KA1) as PTM Enzyme

Protein as Phosphorylation Enzyme

Search:

Substrate Select all O00418 (EEF2K) O14727 (APAF1) O14757 (CHEK1) O60343 (TBC1D4) O75030 (MITF) P01100-1 (FOS) P03372 (ESR1) P03372-1 (ESR1) P11831 (SRF) P13796 (LCP1) P16144 (ITGB4) P16220 (CREB1) P16220-1 (CREB1) P17676 (CEBPB) P17676-1 (CEBPB) P19634 (SLC9A1) P21333 (FLNA) P22736 (NR4A1) P23588 (EIF4B) P25963 (NFKBIA) P29317 (EPHA2) P30304 (CDC25A) P30305 (CDC25B) P30307 (CDC25C) P32004-1 (L1CAM) P42345 (MTOR) P43354-1 (NR4A2) P46527 (CDKN1B) P49427 (CDC34) P49815 (TSC2) P49841 (GSK3B) P50549 (ETV1) P50549-1 (ETV1) P50552 (VASP) P53355 (DAPK1) P60983 (GMFB) P62753 (RPS6) P67809 (YBX1) P78371 (CCT2) P84243 (H3-3B) Q04206 (RELA) Q05195 (MXD1) Q07889 (SOS1) Q13164 (MAPK7) Q15418 (RPS6KA1) Q15418-1 (RPS6KA1) Q15418-2 (RPS6KA1) Q15653 (NFKBIB) Q15831 (STK11) Q16821-1 (PPP1R3A) Q16875 (PFKFB3) Q8IX03 (WWC1) Q8N122 (RPTOR) Q8TB45 (DEPTOR) Q92570 (NR4A3) Q92570-3 (NR4A3) Q92882 (OSTF1) Q92934 (BAD) Q96RK0 (CIC) Q9H6Z4 (RANBP3) Q9HC62 (SENP2) Q9UBP6-1 (METTL1) Q9UN36 (NDRG2) Q9Y2V2 (CARHSP1)	Site Select all By amino acid All Serine All Threonine By position S5 S9 S11 S19 S23 T27 S27 S32 S36 S46 S52 S75 S99 S102 S103 S118 S119 S126 S133 S145 S153 T162 S167 S173 S191 T198 S202 S216 S221 T225 T234 T235 S235 S236 S240 S244 S247 S260 T266 S268 T278 S280 S286 S287 S289 S291 S293 S295 S332 S334 S341 S347 S350 S351 S353 T355 S357 S362 S366 T369 S376 S380 S387 S389 S409 S422 S428 S461 S496 S536 T577 T586 S703 S719 S721 S722 S751 S897 T929 S947 S1134 S1152 S1161 S1364 S1798 S2152 T2446 S2448	Score Select all 0 1 2 3 4	Source Select all HPRD PhosphoSitePlus RLIMS-P+ Signor UniProt neXtProt	PMID
O00418 (EEF2K)	S366	score4	HPRD neXtProt PhosphoSitePlus Signor	11500364, 20837011, 14709557, ...15024086, 11171059
O14727 (APAF1)	S268	score2	PhosphoSitePlus	22246185
O14727 (APAF1)	S357	score2	PhosphoSitePlus	22246185
O14757 (CHEK1)	S280	score3	PhosphoSitePlus	22357623, 23108403
O60343 (TBC1D4)	S341	score2	RLIMS-P+	17617058
O60343 (TBC1D4)	S751	score2	RLIMS-P+	17617058
O75030 (MITF)	S409	score4	neXtProt PhosphoSitePlus Signor	10673502, 21749389
P01100-1 (FOS)	S362	score4	HPRD PhosphoSitePlus Signor	1545828, 8248197, 11585927, ...20068231, 18452278
P03372-1 (ESR1)	S118	score2	HPRD	12093745, 9528769
P03372 (ESR1)	S167	score4	HPRD neXtProt PhosphoSitePlus Signor	7838153, 11432835, 19925796, ...9528769, 11139588, 11507039
P11831 (SRF)	S103	score2	HPRD	10318869, 10753652, 8413226
P13796 (LCP1)	S5	score2	PhosphoSitePlus	26631483
P16144 (ITGB4)	S1364	score2	PhosphoSitePlus	20870721
P16220 (CREB1)	S119	score1	Signor	10558990
P16220-1 (CREB1)	S133	score2	HPRD	11175347, 9687510, 9829964, ...12235136, 8688081
P17676 (CEBPB)	T235	score2	neXtProt	11684016
P17676-1 (CEBPB)	T266	score1	HPRD	10635333
P19634 (SLC9A1)	S703	score3	PhosphoSitePlus Signor	10400637
P21333 (FLNA)	S2152	score3	PhosphoSitePlus Signor	15024089
P22736 (NR4A1)	S351	score4	HPRD neXtProt	11274386, 16223362, 18669648
P23588 (EIF4B)	S422	score4	neXtProt PhosphoSitePlus Signor	16763566, 15071500
P25963 (NFKBIA)	S32	score4	HPRD neXtProt PhosphoSitePlus	8601309, 9914500, 9214631, ...9261139, 10723127, 16822942, 9721103
P25963 (NFKBIA)	S36	score3	neXtProt	9261139, 16822942, 9214631
P29317 (EPHA2)	S897	score2	PhosphoSitePlus	26158630
P30304 (CDC25A)	S293	score3	PhosphoSitePlus Signor	23708659
P30304 (CDC25A)	S295	score3	PhosphoSitePlus Signor	23708659
P30305 (CDC25B)	S353	score3	PhosphoSitePlus Signor	23708659
P30305 (CDC25B)	T355	score3	PhosphoSitePlus Signor	23708659
P30307 (CDC25C)	S247	score2	PhosphoSitePlus	23708659
P32004-1 (L1CAM)	S1152	score1	HPRD	8663493
P42345 (MTOR)	T2446	score1	HPRD	15905173
P42345 (MTOR)	S2448	score2	HPRD	18691976, 19664994, 10910062
P43354-1 (NR4A2)	S347	score1	HPRD	16223362
P46527 (CDKN1B)	T198	score2	neXtProt	14504289
P49427 (CDC34)	T162	score2	RLIMS-P+	27786305
P49815 (TSC2)	S1798	score4	HPRD neXtProt PhosphoSitePlus Signor	15342917, 20068231
P49841 (GSK3B)	S9	score4	neXtProt PhosphoSitePlus Signor	16039586, 7980435, 8250835, ...11584304
P50549-1 (ETV1)	S191	score4	HPRD neXtProt Signor	12569367, 11551945, 12917345, ...12213813
P50549 (ETV1)	S216	score4	HPRD neXtProt Signor	12569367, 11551945, 12917345, ...12213813
P50549 (ETV1)	S334	score4	HPRD neXtProt	12569367, 12213813
P50552 (VASP)	T278	score3	PhosphoSitePlus Signor	21423205
P53355 (DAPK1)	S289	score3	neXtProt PhosphoSitePlus	16213824
P60983 (GMFB)	T27	score3	HPRD PhosphoSitePlus	9030586
P62753 (RPS6)	S235	score3	neXtProt PhosphoSitePlus Signor	17360704
P62753 (RPS6)	S236	score3	neXtProt PhosphoSitePlus Signor	17360704
P62753 (RPS6)	S240	score1	Signor	21233202
P62753 (RPS6)	S244	score1	Signor	21233202
P67809 (YBX1)	S102	score3	neXtProt PhosphoSitePlus Signor	19036157
P78371 (CCT2)	S260	score4	PhosphoSitePlus Signor	21440620, 19332537
P84243 (H3-3B)	S11	score2	Signor	10464286, 14625384, 15994958
Q04206 (RELA)	S536	score2	neXtProt	15802625
Q05195 (MXD1)	S145	score3	PhosphoSitePlus Signor	18451027
Q07889 (SOS1)	S1134	score2	PhosphoSitePlus	22827337
Q07889 (SOS1)	S1161	score2	PhosphoSitePlus	22827337
Q13164 (MAPK7)	S496	score2	PhosphoSitePlus	22267842
Q15418 (RPS6KA1)	S221	score1	Signor	20048145
Q15418-1 (RPS6KA1)	T225	score0	HPRD	17192257, 20068231
Q15418-2 (RPS6KA1)	T234	score0	HPRD	17192257, 20068231
Q15418-1 (RPS6KA1)	S380	score4	HPRD UniProt	18691976, 12618428, 9430688, ...19651622, 18669648, 20068231, 10648825
Q15418-2 (RPS6KA1)	S389	score2	HPRD	18691976, 12618428, 9430688, ...19651622, 18669648, 20068231, 10648825
Q15418-1 (RPS6KA1)	T577	score0	HPRD	18669648, 17192257
Q15418-2 (RPS6KA1)	T586	score0	HPRD	18669648, 17192257
Q15653 (NFKBIB)	S19	score2	neXtProt	16822942
Q15653 (NFKBIB)	S23	score2	neXtProt	16822942
Q15831 (STK11)	S428	score4	neXtProt Signor	25846811, 11297520
Q16821-1 (PPP1R3A)	S46	score1	HPRD	10648825
Q16875 (PFKFB3)	S461	score2	RLIMS-P+	22115192
Q8IX03 (WWC1)	T929	score3	PhosphoSitePlus Signor	24269383
Q8IX03 (WWC1)	S947	score3	PhosphoSitePlus Signor	24269383
Q8N122 (RPTOR)	S719	score3	neXtProt PhosphoSitePlus Signor	18722121
Q8N122 (RPTOR)	S721	score3	neXtProt PhosphoSitePlus Signor	18722121
Q8N122 (RPTOR)	S722	score3	neXtProt PhosphoSitePlus Signor	18722121
Q8TB45 (DEPTOR)	S286	score4	PhosphoSitePlus Signor	22017877, 22017876
Q8TB45 (DEPTOR)	S287	score4	PhosphoSitePlus Signor	22017877, 22017876
Q8TB45 (DEPTOR)	S291	score4	PhosphoSitePlus Signor	22017877, 22017876
Q92570 (NR4A3)	S376	score2	HPRD Signor	16223362
Q92570-3 (NR4A3)	S387	score1	HPRD	16223362
Q92882 (OSTF1)	S202	score2	PhosphoSitePlus	21501342
Q92934 (BAD)	S75	score4	HPRD neXtProt PhosphoSitePlus Signor	16767165, 12897128, 18246127, ...10880354, 10521512, 14678993, 10679322, 10558990, 9381178, 10837486
Q92934 (BAD)	S99	score2	neXtProt	10679322
Q92934 (BAD)	S118	score3	HPRD Signor	20166139, 10837486, 18669648, ...10949026, 18707149
Q92934 (BAD)	S153	score3	HPRD Signor	10880354, 10949026, 10837486
Q96RK0 (CIC)	S173	score3	PhosphoSitePlus Signor	21087211
Q9H6Z4 (RANBP3)	S126	score3	PhosphoSitePlus Signor	18280241
Q9HC62 (SENP2)	T369	score2	PhosphoSitePlus	25689261
Q9UBP6-1 (METTL1)	S27	score3	HPRD PhosphoSitePlus Signor	15861136
Q9UN36 (NDRG2)	S332	score2	PhosphoSitePlus	15461589
Q9UN36 (NDRG2)	S350	score2	PhosphoSitePlus	15461589
Q9Y2V2 (CARHSP1)	S52	score3	PhosphoSitePlus Signor	15910284

Proteoforms

Search:

	PRO ID (Short Label) Select all PR:000049123 (hRPS6KA1/Phos:1) PR:000049124 (hRPS6KA1/Phos:2)	Sites Select all pS221,pS363,pS380,pT573 pS221,pT359,pS363,pS380,pT573,pS732	PTM Enzyme	Source Select all PRO	PMID
	PR:000049123 (hRPS6KA1/Phos:1)	pS221,pS363,pS380,pT573		PRO
	PR:000049124 (hRPS6KA1/Phos:2)	pS221,pT359,pS363,pS380,pT573,pS732		PRO

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine By position S31 S45 K66 S72 S221 S230 S307 K335 S369 S378 S380 S389 S402 K453 T577 T586 S687 T701 S732 S741	Variant Select all A221 A230 A577 A586 A701 C687 F307 F45 F687 F72 F732 F741 L402 M701 N369 N378 N66 P31 P45 P701 Q453 T335 T380 T389	Source Select all Biomuta	Disease [Sample source] Select all DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] DOID:2531 / hematologic cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
S31	P31	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S45	P45	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S45	F45	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
K66	N66	Biomuta	DOID:2531 / hematologic cancer [ cosmic, icgc ]
S72	F72	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S221	A221	Biomuta	DOID:5041 / esophageal cancer [ cosmic ]
S230	A230	Biomuta	DOID:5041 / esophageal cancer [ cosmic ]
S307	F307	Biomuta	DOID:10283 / prostate cancer [ cosmic, icgc ]
K335	T335	Biomuta	DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
S369	N369	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S378	N378	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S380	T380	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S389	T389	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S402	L402	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
K453	Q453	Biomuta	DOID:3571 / liver cancer [ cosmic ]
T577	A577	Biomuta	DOID:10283 / prostate cancer [ cosmic, icgc ]
T586	A586	Biomuta	DOID:10283 / prostate cancer [ cosmic, icgc ]
S687	C687	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S687	F687	Biomuta	DOID:1612 / breast cancer [ cosmic ]
T701	M701	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
T701	A701	Biomuta	DOID:2531 / hematologic cancer [ cosmic, icgc ]
T701	P701	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
S732	F732	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S741	F741	Biomuta	DOID:4159 / skin cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q15418 (RPS6KA1)

Protein Information

Interactive Sequence View

Q15418 (RPS6KA1) as Substrate

Q15418 (RPS6KA1) as PTM Enzyme

Proteoforms

PTM sites affected in variants