iPTMnet Report for Q15399 (TLR1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15399 / TLR1_HUMAN
Protein Name Toll-like receptor 1 precursor
Gene Name Name: TLR1
Synonyms:KIAA0012;
Organism Homo sapiens (Human)

PRO ID PR:Q15399
DAG View
PRO Name Toll-like receptor 1 (human)
Definition A Toll-like receptor 1 that is encoded in the genome of human.
Short Label hTLR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15399 (TLR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S44 Phosphorylation PhosphoSitePlus
T48 Phosphorylation PhosphoSitePlus
N51 N-Glycosylation GlyGen   UniProt 17889651
S53 Phosphorylation PhosphoSitePlus
Y56 Phosphorylation PhosphoSitePlus
N163 N-Glycosylation GlyGen   UniProt 17889651, 19159218, 24190977
N330 N-Glycosylation GlyGen   UniProt 17889651, 24190977
K416 Methylation PhosphoSitePlus
S420 Phosphorylation PhosphoSitePlus
T422 Phosphorylation PhosphoSitePlus
N429 N-Glycosylation GlyGen   UniProt 17889651
S431 Phosphorylation PhosphoSitePlus
T529 Phosphorylation PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
S678 Phosphorylation PhosphoSitePlus
T685 Phosphorylation PhosphoSitePlus
S690 Phosphorylation PhosphoSitePlus
Y691 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S44 P44 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
S44 F44 Biomuta DOID:4159 / skin cancer [ cosmic ]
S53 L53 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
N330 K330 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K416 T416 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T422 I422 Biomuta DOID:4159 / skin cancer [ cosmic ]
S431 Y431 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S678 R678 Biomuta DOID:10534 / stomach cancer [ cosmic ]