iPTMnet Report for Q15389 (ANGPT1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15389 / ANGP1_HUMAN
Protein Name Angiopoietin-1 precursor
Gene Name Name: ANGPT1
Synonyms:KIAA0003;
Organism Homo sapiens (Human)

PRO ID PR:Q15389
DAG View
PRO Name angiopoietin-1 (human)
Definition An angiopoietin-1 that is encoded in the genome of human.
Short Label hANGPT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15389 (ANGPT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Phosphorylation PhosphoSitePlus
S6 Phosphorylation PhosphoSitePlus
S25 Phosphorylation PhosphoSitePlus
N154 N-Glycosylation GlyGen 23090970, 24190977
T181 Phosphorylation PhosphoSitePlus
K186 Acetylation PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
Y300 Phosphorylation PhosphoSitePlus
Y303 Phosphorylation PhosphoSitePlus
T325 Phosphorylation PhosphoSitePlus
Y386 Phosphorylation PhosphoSitePlus
Y389 Phosphorylation PhosphoSitePlus
Y401 Phosphorylation PhosphoSitePlus
Y404 Phosphorylation PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
T409 Phosphorylation PhosphoSitePlus
T411 Phosphorylation PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S6 F6 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K216 N216 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K235 R235 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
S297 R297 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S297 I297 Biomuta DOID:1324 / lung cancer [ cosmic ]
T325 I325 Biomuta DOID:4159 / skin cancer [ cosmic ]
T325 A325 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y401 H401 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y404 C404 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T409 N409 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T411 K411 Biomuta DOID:4159 / skin cancer [ cosmic ]