iPTMnet Report for Q15386 (UBE3C)
Protein Information
| UniProt AC / UniProt ID | Q15386 / UBE3C_HUMAN |
| Protein Name | Ubiquitin-protein ligase E3C |
| Gene Name | Name: UBE3C Synonyms:KIAA0010; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q15386 |
| PRO Name | ubiquitin-protein ligase E3C (human) |
| Definition | A ubiquitin-protein ligase E3C that is encoded in the genome of human. |
| Short Label | hUBE3C |
| Category | organism-gene |
DAG ViewQ15386 (UBE3C) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K9 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S15 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S20 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K25 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S54 | O-Glycosylation | score1 | GlyGen | 30379171, 28510447 | ||
| Y59 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K63 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y66 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C76 | Methylation | score1 | IEDB | 31844290 | ||
| K130 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K145 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K218 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S221 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y225 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K235 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K243 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S366 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S372 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K402 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C429 | Methylation | score1 | IEDB | 31844290 | ||
| Y447 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S464 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S467 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K558 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K565 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K610 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K635 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K638 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S672 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K700 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K710 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K739 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S741 | Phosphorylation | score0 | RLIMS-P | 35914132 | ||
| K749 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K782 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K793 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S845 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T850 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S851 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K868 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K903 | Ubiquitination | score2 | UniProt | 32039437 | ||
| K903 | Ubiquitination | Q15386 (UBE3C) | score2 | UniProt | 32039437 | |
| K907 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T1004 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K1008 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K1013 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K1056 | Ubiquitination | score1 | PhosphoSitePlus |
Q15386 (UBE3C) as PTM Enzyme
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K25 | N25 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| K25 | E25 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K25 | R25 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| K235 | N235 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| K793 | N793 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K868 | N868 | Biomuta | DOID:4362 / cervical cancer [ cosmic, icgc, tcga ] | |
| K903 | N903 | Biomuta | DOID:1324 / lung cancer [ cosmic ] |
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