iPTMnet Report for Q15306 (IRF4)
Protein Information
| UniProt AC / UniProt ID | Q15306 / IRF4_HUMAN |
| Protein Name | Interferon regulatory factor 4 |
| Gene Name | Name: IRF4 Synonyms:MUM1; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q15306 |
| PRO Name | interferon regulatory factor 4 (human) |
| Definition | An interferon regulatory factor 4 that is encoded in the genome of human. |
| Short Label | hIRF4 |
| Category | organism-gene |
Q15306 (IRF4) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| C19 | Methylation | score1 | IEDB | 31844290 | ||
| K36 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y37 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S48 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K59 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y62 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K103 | Acetylation | score1 | PhosphoSitePlus | |||
| K103 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y122 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K123 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y125 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S177 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y181 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y192 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R201 | Methylation | score1 | PhosphoSitePlus | |||
| C250 | Methylation | score1 | IEDB | 31844290 | ||
| K264 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K306 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S309 | O-Glycosylation | score1 | GlyGen | 30379171 | ||
| Y325 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K327 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K349 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C356 | Methylation | score1 | IEDB | 31844290 | ||
| K357 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K399 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y414 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y428 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y440 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S447 | Phosphorylation | O75116 (ROCK2) | score3 | PhosphoSitePlus Signor | 20697158 | |
| S448 | Phosphorylation | O75116 (ROCK2) | score1 | Signor | 20697158 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| C19 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| K36 | N36 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| Y37 | * | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| S48 | R48 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| K59 | R59 | Biomuta | DOID:2531 / hematologic cancer [ cosmic, icgc ] | |
| Y62 | * | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| K123 | R123 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] | |
| Y192 | H192 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
| R201 | H201 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| K264 | R264 | Biomuta | DOID:2394 / ovarian cancer [ cosmic, icgc ] | |
| K306 | N306 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| C356 | Y356 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| Y428 | * | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| Y428 | H428 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| S447 | Y447 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] |
DAG View