iPTMnet Report for Q15303 (ERBB4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15303 / ERBB4_HUMAN
Protein Name Receptor tyrosine-protein kinase erbB-4 precursor
Gene Name Name: ERBB4
Synonyms:HER4;
Organism Homo sapiens (Human)

PRO ID PR:Q15303
DAG View
PRO Name receptor tyrosine-protein kinase erbB-4 (human)
Definition A receptor tyrosine-protein kinase erbB-4 that is encoded in the genome of human.
Short Label hERBB4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15303 (ERBB4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N138 N-Glycosylation GlyGen   UniProt 16203964
Y157 Phosphorylation PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
N174 N-Glycosylation GlyGen   UniProt 16203964
S183 Phosphorylation PhosphoSitePlus
N253 N-Glycosylation GlyGen   UniProt 16203964
T327 Phosphorylation PhosphoSitePlus
N358 N-Glycosylation GlyGen   UniProt 16203964
N410 N-Glycosylation GlyGen   UniProt 16203964
N473 N-Glycosylation GlyGen   UniProt 16203964
N495 N-Glycosylation GlyGen   UniProt 16203964
N576 N-Glycosylation GlyGen   UniProt 16203964
T699 Phosphorylation PhosphoSitePlus
K714 Sumoylation PhosphoSitePlus
K714 Ubiquitination PhosphoSitePlus
K722 Ubiquitination PhosphoSitePlus
S726 Phosphorylation PhosphoSitePlus
T731 Phosphorylation PhosphoSitePlus
Y733 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus 18083107, 16729043
K745 Ubiquitination PhosphoSitePlus
K852 Ubiquitination PhosphoSitePlus
K858 Ubiquitination PhosphoSitePlus
K873 Acetylation PhosphoSitePlus
Y875 Phosphorylation PhosphoSitePlus   UniProt 18721752
Y875 Phosphorylation Q15303 (ERBB4) UniProt 18721752
K881 Acetylation PhosphoSitePlus
K935 Ubiquitination PhosphoSitePlus
Y984 Phosphorylation IntAct   PhosphoSitePlus   RLIMS-P 27374103, 16729043, 32415868
Y1022 Phosphorylation IntAct   PhosphoSitePlus 16729043
Y1035 Phosphorylation PhosphoSitePlus   UniProt 18721752
Y1035 Phosphorylation Q15303 (ERBB4) UniProt 18721752
S1043 Phosphorylation PhosphoSitePlus
S1051 Phosphorylation PhosphoSitePlus
Y1056 Phosphorylation IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18721752, 16934755, 8617750, ...17120616, 18236211, 21396094, 24791013, 16729043, 32415868
Y1056 Phosphorylation Q15303 (ERBB4) neXtProt   PhosphoSitePlus   UniProt 16934755, 17120616
Y1066 Phosphorylation PhosphoSitePlus
Y1081 Phosphorylation PhosphoSitePlus
Y1128 Phosphorylation PhosphoSitePlus
S1140 Phosphorylation PhosphoSitePlus
Y1150 Phosphorylation PhosphoSitePlus   UniProt 18721752
Y1150 Phosphorylation Q15303 (ERBB4) UniProt 18721752
Y1162 Phosphorylation IntAct   PhosphoSitePlus   UniProt 18721752, 16729043, 16273093
Y1162 Phosphorylation Q15303 (ERBB4) UniProt 18721752
Y1188 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   UniProt 8617750, 16729043, 16273093, ...18721752
Y1188 Phosphorylation Q15303 (ERBB4) UniProt 18721752
Y1202 Phosphorylation IntAct   PhosphoSitePlus   UniProt 18721752, 16729043
Y1202 Phosphorylation Q15303 (ERBB4) UniProt 18721752
Y1208 Phosphorylation IntAct   PhosphoSitePlus 16729043
Y1221 Phosphorylation IntAct   PhosphoSitePlus 16729043
Y1242 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 8617750, 16729043, 31371697, ...18721752
Y1242 Phosphorylation Q15303 (ERBB4) UniProt 18721752
Y1258 Phosphorylation IntAct   PhosphoSitePlus   UniProt 18721752, 16273093
Y1258 Phosphorylation Q15303 (ERBB4) UniProt 18721752
Y1262 Phosphorylation PhosphoSitePlus
K1265 Ubiquitination PhosphoSitePlus
Y1266 Phosphorylation PhosphoSitePlus
Y1268 Phosphorylation IntAct   PhosphoSitePlus 16729043
Y1284 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18721752, 31371697, 19878607, ...8617750, 21396094, 16729043, 16273093
Y1284 Phosphorylation Q15303 (ERBB4) UniProt 18721752
Y1301 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y157 Phosphorylation HPRD 18452278
S173 Phosphorylation HPRD 18452278
S183 Phosphorylation HPRD 18452278
Y733 Phosphorylation HPRD 16729043
Y984 Phosphorylation HPRD 16729043
Y1022 Phosphorylation HPRD 16729043
Y1056 Phosphorylation HPRD 16729043
Y1162 Phosphorylation HPRD 16729043
Y1188 Phosphorylation HPRD 16729043
Y1202 Phosphorylation HPRD 16729043
Y1208 Phosphorylation HPRD 16729043
Y1221 Phosphorylation HPRD 16729043
Y1242 Phosphorylation HPRD 16729043
Y1268 Phosphorylation HPRD 16729043
Y1284 Phosphorylation HPRD 16729043
Site PTM Type PTM Enzyme Score Source PMID
Y157 Phosphorylation HPRD 18452278
S173 Phosphorylation HPRD 18452278
S183 Phosphorylation HPRD 18452278
Y733 Phosphorylation HPRD 16729043
Y984 Phosphorylation HPRD 16729043
Y1022 Phosphorylation HPRD 16729043
S1043 Phosphorylation PhosphoSitePlus
Y1242 Phosphorylation HPRD 16729043
Y1268 Phosphorylation HPRD 16729043
Site PTM Type PTM Enzyme Score Source PMID
S1033 Phosphorylation PhosphoSitePlus


Q15303 (ERBB4) as PTM Enzyme



Substrate Site Score Source PMID
Q15303 (ERBB4) Y875 UniProt 18721752
Q15303 (ERBB4) Y1035 UniProt 18721752
Q15303 (ERBB4) Y1056 neXtProt   PhosphoSitePlus   UniProt 16934755, 17120616
Q15303 (ERBB4) Y1150 UniProt 18721752
Q15303 (ERBB4) Y1162 UniProt 18721752
Q15303 (ERBB4) Y1188 UniProt 18721752
Q15303 (ERBB4) Y1202 UniProt 18721752
Q15303 (ERBB4) Y1242 UniProt 18721752
Q15303 (ERBB4) Y1258 UniProt 18721752
Q15303 (ERBB4) Y1284 UniProt 18721752


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N138 H138 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
N138 S138 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
Y157 C157 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S173 T173 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
N174 S174 Biomuta DOID:263 / kidney cancer [ cosmic ]
N253 Y253 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
T327 I327 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
N358 K358 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
N473 T473 Biomuta DOID:4159 / skin cancer [ cosmic ]
N473 K473 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T731 M731 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
K745 T745 Biomuta DOID:4159 / skin cancer [ cosmic ]
K745 N745 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y875 F875 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y875 C875 Biomuta DOID:1319 / brain cancer [ cosmic ]
K881 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K935 I935 Biomuta DOID:1324 / lung cancer [ cosmic ]
K935 T935 Biomuta [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc, cosmic, cosmic, cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
Y1022 C1022 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
Y1035 H1035 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1043 * Biomuta [ cosmic ]
S1043 L1043 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S1051 R1051 Biomuta [ cosmic ]
Y1056 F1056 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1066 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1128 H1128 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S1140 N1140 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1140 I1140 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
Y1150 C1150 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
Y1188 C1188 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y1242 C1242 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:3277 / thymus cancer [ cosmic ]
Y1242 F1242 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y1258 C1258 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
Y1262 C1262 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y1262 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1266 H1266 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1301 C1301 Biomuta DOID:9256 / colorectal cancer [ cosmic ]