iPTMnet Report for Q15262 (PTPRK)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15262 / PTPRK_HUMAN
Protein Name Receptor-type tyrosine-protein phosphatase kappa precursor
Gene Name Name: PTPRK
Synonyms:PTPK;
Organism Homo sapiens (Human)

PRO ID PR:Q15262
DAG View
PRO Name receptor-type tyrosine-protein phosphatase kappa (human)
Definition A receptor-type tyrosine-protein phosphatase kappa that is encoded in the genome of human.
Short Label hPTPRK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15262 (PTPRK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N101 N-Glycosylation GlyGen 23090970, 29391424, 24190977
C105 Methylation IEDB 31844290
N140 N-Glycosylation GlyGen 23090970, 29741879, 29391424, ...24190977
K194 Ubiquitination PhosphoSitePlus
N211 N-Glycosylation GlyGen 23090970, 29741879, 29391424, ...24190977
K227 Ubiquitination PhosphoSitePlus
K262 Ubiquitination PhosphoSitePlus
T357 Phosphorylation PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
N416 N-Glycosylation GlyGen   UniProt 19159218, 24190977, 23090970, ...29391424, 19349973, 29741879
N436 N-Glycosylation GlyGen 23090970, 24190977
N462 N-Glycosylation GlyGen 23090970, 29671580, 29391424, ...32125861, 24190977
K476 Ubiquitination PhosphoSitePlus
T485 Phosphorylation PhosphoSitePlus
K778 Acetylation PhosphoSitePlus
T790 Phosphorylation PhosphoSitePlus
Y805 Phosphorylation PhosphoSitePlus
S828 Phosphorylation PhosphoSitePlus
Y831 Phosphorylation PhosphoSitePlus
N833 N-Glycosylation GlyGen 29391424
S835 Phosphorylation PhosphoSitePlus
Y849 Phosphorylation PhosphoSitePlus
T854 Phosphorylation PhosphoSitePlus
S856 Phosphorylation PhosphoSitePlus
Y858 Phosphorylation PhosphoSitePlus
T860 Phosphorylation PhosphoSitePlus
Y916 Phosphorylation PhosphoSitePlus
Y922 Phosphorylation PhosphoSitePlus
Y940 Phosphorylation PhosphoSitePlus
Y945 Phosphorylation PhosphoSitePlus
Y1158 Phosphorylation PhosphoSitePlus
K1174 Ubiquitination PhosphoSitePlus
T1184 Phosphorylation PhosphoSitePlus
Y1294 Phosphorylation PhosphoSitePlus
K1360 Ubiquitination PhosphoSitePlus
K1415 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N462 N-Glycosylation PRO 29671580
Site PTM Type PTM Enzyme Score Source PMID
S857 Phosphorylation HPRD 19664994
T861 Phosphorylation HPRD 19664994
Y1093 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K262 R262 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T357 I357 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T357 S357 Biomuta DOID:4159 / skin cancer [ cosmic ]
T854 M854 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T854 A854 Biomuta DOID:1324 / lung cancer [ cosmic ]
S856 F856 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S857 F857 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T860 I860 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T861 I861 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y922 * Biomuta DOID:4159 / skin cancer [ cosmic ]
Y922 H922 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1174 R1174 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1184 I1184 Biomuta DOID:1319 / brain cancer [ cosmic ]
T1184 A1184 Biomuta DOID:263 / kidney cancer [ cosmic ]
Y1294 H1294 Biomuta DOID:1319 / brain cancer [ cosmic ]