Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15233 / NONO_HUMAN
Protein Name Non-POU domain-containing octamer-binding protein
Gene Name Name: NONO
Synonyms:NRB54;
Organism Homo sapiens (Human)

PRO ID PR:Q15233
DAG View
PRO Name non-POU domain-containing octamer-binding protein (human)
Definition A non-POU domain-containing octamer-binding protein that is encoded in the genome of human.
Short Label hNONO
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15233 (NONO) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Acetylation PhosphoSitePlus   UniProt 19608861
K5 Methylation PhosphoSitePlus
K5 Sumoylation PhosphoSitePlus
K5 Ubiquitination PhosphoSitePlus
T6 Phosphorylation PhosphoSitePlus   UniProt 23186163
K11 Acetylation PhosphoSitePlus   UniProt 19608861
K11 Sumoylation PhosphoSitePlus
K11 Ubiquitination PhosphoSitePlus
T15 Phosphorylation PhosphoSitePlus
K60 Sumoylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
K64 Sumoylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K68 Acetylation PhosphoSitePlus
K68 Sumoylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
T86 Phosphorylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K96 Acetylation PhosphoSitePlus
K96 Sumoylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
K99 Sumoylation PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
K107 Acetylation PhosphoSitePlus
K107 Sumoylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
K109 Acetylation PhosphoSitePlus
K109 Sumoylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
R115 Methylation PhosphoSitePlus
K126 Acetylation PhosphoSitePlus
K126 Sumoylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
R135 Methylation PhosphoSitePlus
C145 S-Nitrosylation dbSNO 19483679, 2212679, 22126794, ...22178444, 26338901
S147 O-Glycosylation GlyGen 23301498, 30444036, 30397120, ...20305658, 32119511, 28510447, 22121020
S147 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231, 18220336
S149 Phosphorylation PhosphoSitePlus
T151 Phosphorylation PhosphoSitePlus
R184 Methylation PhosphoSitePlus
R186 Methylation PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus
K190 Acetylation PhosphoSitePlus
K190 Methylation PhosphoSitePlus
K190 Sumoylation PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
K198 Acetylation PhosphoSitePlus   UniProt 19608861
K198 Sumoylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
K239 Sumoylation PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
K243 Acetylation PhosphoSitePlus
K243 Sumoylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
R256 Methylation PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y265 Phosphorylation PhosphoSitePlus
Y267 Phosphorylation PhosphoSitePlus
K272 Sumoylation PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
K279 Sumoylation PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
R287 Methylation PhosphoSitePlus
K290 Sumoylation PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
K295 Acetylation PhosphoSitePlus
K295 Sumoylation PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
R304 Methylation PhosphoSitePlus
R325 Methylation PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
R343 Methylation PhosphoSitePlus
R364 Methylation PhosphoSitePlus
K371 Acetylation PhosphoSitePlus
K371 Sumoylation PhosphoSitePlus
K371 Ubiquitination PhosphoSitePlus
T373 Phosphorylation PhosphoSitePlus
T410 Phosphorylation PhosphoSitePlus
T418 Phosphorylation PhosphoSitePlus
T424 Phosphorylation PhosphoSitePlus
T428 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 19690332, ...17924679
T431 Phosphorylation PhosphoSitePlus
T432 Phosphorylation PhosphoSitePlus
T440 Phosphorylation PhosphoSitePlus   UniProt 20068231
T450 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 17287340, ...17081983, 18220336, 18669648, 24275569, 17693683, 23186163, 17924679, 19690332, 20068231, 16964243
R456 Methylation PhosphoSitePlus   UniProt 24129315
K467 Acetylation PhosphoSitePlus
K467 Methylation PhosphoSitePlus
K467 Sumoylation PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
Y471 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO
T15 Phosphorylation HPRD 20068231
S147 Phosphorylation HPRD 18669648, 20068231
S149 Phosphorylation HPRD 18212344
S188 Phosphorylation HPRD 20068231
S209 Phosphorylation HPRD 18452278
T424 Phosphorylation HPRD 20068231
T428 Phosphorylation HPRD 19413330, 18691976, 19664995, ...18669648, 20068231, 17924679
T432 Phosphorylation HPRD 17081983
T440 Phosphorylation HPRD 18491316, 20068231
T450 Phosphorylation HPRD 19413330, 18691976, 18491316, ...17287340, 16964243, 20230923, 18767875, 20058876, 18452278, 17322306, 18669648, 17693683, 17924679, 19415658, 20068231, 20068230


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036306 (hNONO/Ac:1) acM1 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K5 N5 Biomuta DOID:9256 / colorectal cancer [ tcga ]
R115 H115 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R135 C135 Biomuta DOID:363 / uterine cancer [ tcga ]
S147 I147 Biomuta DOID:3571 / liver cancer [ icgc ]
S149 P149 Biomuta DOID:2531 / hematologic cancer [ icgc ]
R184 L184 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S188 P188 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:3070 / malignant glioma [ tcga ]
S188 * Biomuta DOID:1319 / brain cancer [ icgc ] DOID:3070 / malignant glioma [ cosmic ]
S212 F212 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K249 Q249 Biomuta DOID:1324 / lung cancer [ cosmic ]
R256 I256 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S262 F262 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
Y265 * Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
R287 C287 Biomuta DOID:9256 / colorectal cancer [ tcga ]
R304 H304 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
R325 M325 Biomuta DOID:363 / uterine cancer [ tcga ]
R364 Q364 Biomuta DOID:11934 / head and neck cancer [ tcga ]
R364 W364 Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:3070 / malignant glioma [ tcga ]
K371 R371 Biomuta DOID:363 / uterine cancer [ tcga ]
T410 P410 Biomuta DOID:1612 / breast cancer [ tcga ] DOID:10534 / stomach cancer [ icgc, tcga ]
T428 N428 Biomuta DOID:1324 / lung cancer [ cosmic ]
T431 P431 Biomuta DOID:363 / uterine cancer [ tcga ]
T450 N450 Biomuta DOID:363 / uterine cancer [ tcga ]
R456 H456 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R456 C456 Biomuta DOID:3070 / malignant glioma [ tcga ]
Y471 H471 Biomuta DOID:263 / kidney cancer [ cosmic ]