iPTMnet Report for Q15223 (NECTIN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15223 / NECT1_HUMAN
Protein Name Nectin-1 precursor
Gene Name Name: NECTIN1
Synonyms:HVEC,PRR1,PVRL1;
Organism Homo sapiens (Human)

PRO ID PR:Q15223
DAG View
PRO Name nectin-1 (human)
Definition A nectin-1 that is encoded in the genome of human.
Short Label hNECTIN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15223 (NECTIN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S52 Phosphorylation PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
N72 N-Glycosylation GlyGen   UniProt 21980294
N139 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 21980294, ...24190977
K145 Ubiquitination PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
N200 N-Glycosylation GlyGen 24190977
N202 N-Glycosylation GlyGen   UniProt 16335952, 24190977, 23090970, ...22902367, 19139490, 21980294, 29741879
Y211 Phosphorylation PhosphoSitePlus
N286 N-Glycosylation GlyGen 24190977
N297 N-Glycosylation GlyGen 29741879, 24190977
N307 N-Glycosylation GlyGen 24190977
N332 N-Glycosylation GlyGen   UniProt 19349973
T339 O-Glycosylation GlyGen 30459171
K386 Ubiquitination PhosphoSitePlus
Y389 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
T391 Phosphorylation PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
Y396 Phosphorylation PhosphoSitePlus
Y400 Phosphorylation PhosphoSitePlus
Y418 Phosphorylation PhosphoSitePlus
S422 Phosphorylation PhosphoSitePlus   UniProt 21406692
K427 Ubiquitination PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus   UniProt 21406692
S435 Phosphorylation PhosphoSitePlus
Y436 Phosphorylation PhosphoSitePlus
Y460 Phosphorylation PhosphoSitePlus
K465 Ubiquitination PhosphoSitePlus
Y468 Phosphorylation PhosphoSitePlus
T470 Phosphorylation PhosphoSitePlus
Y481 Phosphorylation PhosphoSitePlus
Y488 Phosphorylation PhosphoSitePlus
Y490 Phosphorylation PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S422 Phosphorylation HPRD 18510355
Y468 Phosphorylation HPRD 17016520, 19901323


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S59 N59 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
N202 S202 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
N307 D307 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K427 M427 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S435 T435 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y468 * Biomuta DOID:1319 / brain cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]