iPTMnet Report for Q15185 (PTGES3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15185 / TEBP_HUMAN
Protein Name Prostaglandin E synthase 3
Gene Name Name: PTGES3
Synonyms:P23,TEBP;
Organism Homo sapiens (Human)

PRO ID PR:Q15185
DAG View
PRO Name prostaglandin E synthase 3 (human)
Definition A prostaglandin E synthase 3 that is encoded in the genome of human.
Short Label hPTGES3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15185 (PTGES3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K7 Acetylation PhosphoSitePlus
K7 Ubiquitination PhosphoSitePlus
Y14 Phosphorylation PhosphoSitePlus
K33 Acetylation PhosphoSitePlus   UniProt 19608861
K33 Methylation PhosphoSitePlus
K33 Sumoylation PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
K35 Acetylation PhosphoSitePlus
K35 Sumoylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus
C40 S-Nitrosylation dbSNO 19483679
S44 Phosphorylation PhosphoSitePlus   UniProt 23186163
K48 Acetylation PhosphoSitePlus
K48 Methylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
C58 Methylation IEDB 31844290
C58 S-Nitrosylation dbSNO 26338901
S64 Phosphorylation PhosphoSitePlus
K65 Acetylation PhosphoSitePlus
K65 Sumoylation PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
C75 S-Nitrosylation dbSNO 19483679, 26338901
C76 S-Nitrosylation dbSNO 19483679, 26338901
K79 Sumoylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
K91 Acetylation PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
K95 Sumoylation PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
S113 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18691976, 21406692, 17487921, ...18088087, 17081983, 19369195, 16807684, 16094384, 18669648, 18318008, 19367720, 18166671, 24275569, 23186163, 15040786, 19690332, 20068231
S118 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15040786, 17081983, 20068231
S124 Phosphorylation PhosphoSitePlus
M130 Phosphorylation UniProt 24275569
S148 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 17287340, 17081983, ...18669648, 24275569
S151 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 17287340, 17081983, ...18669648, 24275569
Site PTM Type PTM Enzyme Score Source PMID
S85 Phosphorylation HPRD 20166139, 20068231
S100 Phosphorylation HPRD 20068231
S113 Phosphorylation HPRD 19413330, 18691976, 18088087, ...16094384, 18767875, 20058876, 19664995, 19651622, 18510355, 18669648, 20187088, 18707149, 20166139, 19415658, 20068231
S118 Phosphorylation HPRD 19651622, 17081983, 20068231
S124 Phosphorylation HPRD 17081983, 20068231, 19415658
S148 Phosphorylation HPRD 19413330, 18691976, 17287340, ...17081983, 18669648, 20068231
S151 Phosphorylation HPRD 19413330, 18691976, 17287340, ...17081983, 18669648, 19415658, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S39 N39 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S39 T39 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S44 N44 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S44 G44 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S64 C64 Biomuta DOID:1612 / breast cancer [ icgc ]
K65 T65 Biomuta DOID:1612 / breast cancer [ icgc ]
S72 * Biomuta DOID:1612 / breast cancer [ cosmic ]
C76 Y76 Biomuta DOID:4159 / skin cancer [ cosmic ]
S118 C118 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S148 * Biomuta DOID:1324 / lung cancer [ cosmic ]