iPTMnet Report for Q15147 (PLCB4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15147 / PLCB4_HUMAN
Protein Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Gene Name Name: PLCB4
Organism Homo sapiens (Human)

PRO ID PR:Q15147
DAG View
PRO Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (human)
Definition A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 that is encoded in the genome of human.
Short Label hPLCB4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15147 (PLCB4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S63 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
S503 Phosphorylation PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus
K528 Ubiquitination PhosphoSitePlus
Y721 Phosphorylation PhosphoSitePlus
K839 Ubiquitination PhosphoSitePlus
S843 Phosphorylation PhosphoSitePlus
S867 Phosphorylation PhosphoSitePlus
T886 Phosphorylation PhosphoSitePlus   UniProt 21406692
S889 Phosphorylation PhosphoSitePlus
S890 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
K923 Ubiquitination PhosphoSitePlus
K926 Ubiquitination PhosphoSitePlus
K934 Acetylation PhosphoSitePlus
K937 Acetylation PhosphoSitePlus
K943 Acetylation PhosphoSitePlus
K944 Acetylation PhosphoSitePlus
K945 Acetylation PhosphoSitePlus
K955 Ubiquitination PhosphoSitePlus
K986 Acetylation PhosphoSitePlus
K995 Acetylation PhosphoSitePlus
K996 Acetylation PhosphoSitePlus
T998 Phosphorylation PhosphoSitePlus
T1004 Phosphorylation PhosphoSitePlus
K1010 Ubiquitination PhosphoSitePlus
K1014 Ubiquitination PhosphoSitePlus
T1021 Phosphorylation PhosphoSitePlus
K1022 Ubiquitination PhosphoSitePlus
K1052 Ubiquitination PhosphoSitePlus
K1138 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K1149 Ubiquitination PhosphoSitePlus
K1156 Ubiquitination PhosphoSitePlus
S1186 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S67 N67 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K208 T208 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K215 N215 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y721 H721 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y721 C721 Biomuta DOID:363 / uterine cancer [ icgc ]
K839 N839 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S867 R867 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S890 I890 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic, icgc ]
K923 R923 Biomuta DOID:1324 / lung cancer [ cosmic ]
K926 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K955 T955 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K996 N996 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1004 M1004 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T1021 I1021 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1022 N1022 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1052 R1052 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]