iPTMnet Report for Q15139 (PRKD1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15139 / KPCD1_HUMAN
Protein Name Serine/threonine-protein kinase D1
Gene Name Name: PRKD1
Synonyms:PKD,PKD1,PRKCM;
Organism Homo sapiens (Human)

PRO ID PR:Q15139
DAG View
PRO Name serine/threonine-protein kinase D1 (human)
Definition A serine/threonine-protein kinase D1 that is encoded in the genome of human.
Short Label hPRKD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15139 (PRKD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation RLIMS-P 29652915
Y95 Phosphorylation P12931 (SRC) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17804414
S205 Phosphorylation Q15139 (PRKD1) , P17612 (PRKACA) , P98161 (PKD1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 19369195, 21406692, 19664994, ...21644927, 10867018
S208 Phosphorylation O15264 (MAPK13) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 15755722, 19135240, 21406692
T210 Phosphorylation PhosphoSitePlus
T217 Phosphorylation HPRD   PhosphoSitePlus 19413330
S219 Phosphorylation phospho.ELM   PhosphoSitePlus 15755722
S223 Phosphorylation phospho.ELM   PhosphoSitePlus 15755722
T224 Phosphorylation PhosphoSitePlus
S225 Phosphorylation PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
S237 Phosphorylation HPRD   PhosphoSitePlus 19413330
S239 Phosphorylation PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
S249 Phosphorylation O15264 (MAPK13) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 10867018, 19135240
K292 Ubiquitination PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus   UniProt 19369195
S379 Phosphorylation PhosphoSitePlus
T395 Phosphorylation PhosphoSitePlus
S397 Phosphorylation O15264 (MAPK13) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 17322306, 19413330, 19135240, ...18220336
T400 Phosphorylation PhosphoSitePlus
S401 Phosphorylation O15264 (MAPK13) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18669648, 19135240
S412 Phosphorylation Q05655 (PRKCD) PhosphoSitePlus   RLIMS-P 21726532
S421 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus 21644927
T422 Phosphorylation PhosphoSitePlus
Y432 Phosphorylation A0A173G4P4 (Abl fusion) , P12931 (SRC) , P00519 (ABL1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12637538
Y443 Phosphorylation PhosphoSitePlus
S448 Phosphorylation PhosphoSitePlus   UniProt 19369195
S460 Phosphorylation PhosphoSitePlus
Y463 Phosphorylation P12931 (SRC) , A0A173G4P4 (Abl fusion) , P00519 (ABL1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12505989, 16891660, 12637538, ...15226414, 15024053
S473 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 19369195, 31289638
Y502 Phosphorylation P12931 (SRC) , A0A173G4P4 (Abl fusion) , P00519 (ABL1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12637538
S548 Phosphorylation PhosphoSitePlus
S549 Phosphorylation PhosphoSitePlus
K612 Acetylation PhosphoSitePlus
K622 Ubiquitination PhosphoSitePlus
K675 Ubiquitination PhosphoSitePlus
K708 Ubiquitination PhosphoSitePlus
K724 Ubiquitination PhosphoSitePlus
K737 Ubiquitination PhosphoSitePlus
S738 Phosphorylation Q05513 (PRKCZ) , P24723 (PRKCH) , Q15139 (PRKD1) , P17252 (PRKCA) , Q05655 (PRKCD) , O94806 (PRKD3) , Q02156 (PRKCE) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11741879, 20444975, 15226414, ...31406020, 15383279, 10197446, 11948398, 28703804, 10867018, 15024053, 12407104, 18692497, 32082170
S742 Phosphorylation O94806 (PRKD3) , Q05513 (PRKCZ) , Q02156 (PRKCE) , Q05655 (PRKCD) , Q15139 (PRKD1) , P24723 (PRKCH) , O15264 (MAPK13) , P17252 (PRKCA) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11741879, 20444975, 15226414, ...18220336, 31406020, 29933512, 15383279, 18669648, 19135240, 10197446, 11948398, 18337243, 10867018, 15024053, 12407104, 32082170
T746 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
Y749 Phosphorylation PhosphoSitePlus
S890 Phosphorylation PhosphoSitePlus
S892 Phosphorylation PhosphoSitePlus
S910 Phosphorylation Q15139 (PRKD1) , P98161 (PKD1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19413330, 17703233, 21292998, ...10473617, 14607845, 26304723, 11741879, 31289638, 16563698, 32082170, 28703804, 25889812, 21209314, 10867018, 11401472, 19029298


Q15139 (PRKD1) as PTM Enzyme



Substrate Site Score Source PMID
O00206 (TLR4) S790 neXtProt   PhosphoSitePlus 20557879
O14558 (HSPB6) S16 PhosphoSitePlus 26443497
O15273 (TCAP) S157 PhosphoSitePlus 24280220
O15273 (TCAP) S161 PhosphoSitePlus 24280220
O43865 (AHCYL1) S68 neXtProt 17635105
O60602 (TLR5) S805 neXtProt   PhosphoSitePlus   Signor 20557879, 17442957
O75628 (REM1) S18 PhosphoSitePlus 22076634
O95863 (SNAI1) S11 neXtProt   PhosphoSitePlus   RLIMS-P+   Signor 25203322, 22276203, 20940406, ...22791710
O96013 (PAK4) S99 PhosphoSitePlus 23841590
P00533 (EGFR) T678 neXtProt 10523301
P00533 (EGFR) T693 neXtProt 10523301
P02686-5 (MBP) S162 neXtProt   PhosphoSitePlus 17939756
P04792 (HSPB1) S82 neXtProt   PhosphoSitePlus   RLIMS-P+ 18440775, 15728188
P05412 (JUN) S63 neXtProt   PhosphoSitePlus 11948398
P05549 (TFAP2A) S258 neXtProt   PhosphoSitePlus 18845787
P05549 (TFAP2A) S326 neXtProt   PhosphoSitePlus 18845787
P16144-2 (ITGB4) T1736 PhosphoSitePlus 22357621
P19174 (PLCG1) S1248 HPRD   Signor 19651622, 1370476, 20068231, ...8885868
P19429 (TNNI3) S23 neXtProt 15514163
P19429 (TNNI3) S24 neXtProt 15514163
P22059 (OSBP) S240 PhosphoSitePlus   RLIMS-P+   Signor 21285358, 20444975
P23528 (CFL1) S3 PhosphoSitePlus 19329994
P27986 (PIK3R1) S652 neXtProt 21825134
P31749 (AKT1) T308 PhosphoSitePlus 12167717
P31749 (AKT1) S473 PhosphoSitePlus 12167717
P35222 (CTNNB1) T112 neXtProt   PhosphoSitePlus   Signor 19141652
P35222 (CTNNB1) T120 neXtProt   PhosphoSitePlus   Signor 19141652, 22511927
P35670 (ATP7B) S478 Signor 21189263
P35670 (ATP7B) S481 Signor 21189263
P35670 (ATP7B) S1121 Signor 21189263
P35670 (ATP7B) S1453 Signor 21189263
P43405 (SYK) S291 neXtProt 20956537, 8885868
P48426 (PIP4K2A) T376 neXtProt   PhosphoSitePlus   Signor 16563698
P50552 (VASP) S157 PhosphoSitePlus 23846685
P50552 (VASP) S322 PhosphoSitePlus 23846685
P53367-2 (ARFIP1) S100 PhosphoSitePlus 23695357
P53367 (ARFIP1) S132 PhosphoSitePlus   Signor 22981988, 23695357
Q13563 (PKD2) S801 Signor 20881056
Q13671 (RIN1) S292 neXtProt   PhosphoSitePlus   Signor 21209314
Q13671 (RIN1) S351 neXtProt   PhosphoSitePlus   Signor 21209314, 11784866
Q13936 (CACNA1C) T1928 neXtProt 19527072
Q13936 (CACNA1C) S1981 PhosphoSitePlus   Signor 22100296
Q14247 (CTTN) S298 neXtProt   PhosphoSitePlus   Signor 20363754, 19038333
Q14247 (CTTN) S348 neXtProt   PhosphoSitePlus   Signor 19038333
Q14896 (MYBPC3) S304 neXtProt   PhosphoSitePlus 20018870
Q15139 (PRKD1) S205 HPRD   neXtProt   Signor 10867018, 19664994
Q15139 (PRKD1) S738 HPRD 11741879, 10867018
Q15139 (PRKD1) S742 HPRD   PhosphoSitePlus   UniProt 18669648, 10867018, 15024053, ...18337243
Q15139 (PRKD1) S910 HPRD   neXtProt   PhosphoSitePlus   Signor   UniProt 19413330, 17703233, 10473617, ...14607845, 11741879, 16563698, 11401472, 10867018, 19029298
Q15276 (RABEP1) S407 neXtProt   PhosphoSitePlus 22975325
Q7KZI7 (MARK2) S400 neXtProt   PhosphoSitePlus 19011111
Q8NER1 (TRPV1) S117 neXtProt 15471852
Q8WUI4 (HDAC7) S155 neXtProt   PhosphoSitePlus   Signor 18509061, 18617643, 15623513
Q8WUI4-5 (HDAC7) S194 HPRD 18767875, 15623513, 16956611
Q8WUI4-5 (HDAC7) S220 HPRD 20068231, 15738054
Q8WUI4 (HDAC7) S358 neXtProt   PhosphoSitePlus   Signor 18509061, 18617643, 15623513
Q8WUI4-5 (HDAC7) S397 HPRD 15623513, 18669648, 16956611
Q8WUI4 (HDAC7) S486 neXtProt   PhosphoSitePlus   Signor 18509061, 18617643, 15623513
Q8WYL5 (SSH1) S402 neXtProt   PhosphoSitePlus 21525957
Q8WYL5 (SSH1) S937 neXtProt   PhosphoSitePlus   Signor 21525957, 19567672
Q8WYL5 (SSH1) S978 neXtProt   PhosphoSitePlus   Signor 21525957, 19329994, 19567672
Q92918 (MAP4K1) S171 neXtProt   PhosphoSitePlus 15743830
Q92934 (BAD) S75 neXtProt   PhosphoSitePlus   Signor 20179209
Q92934 (BAD) S99 neXtProt   PhosphoSitePlus   Signor 20179209
Q92934 (BAD) S118 neXtProt   PhosphoSitePlus   Signor 20179209
Q96A00 (PPP1R14A) T38 HPRD   neXtProt   PhosphoSitePlus   Signor 15003508, 32471307
Q96QB1 (DLC1) S1244 neXtProt   PhosphoSitePlus   Signor 21087603
Q99683 (MAP3K5) T838 PhosphoSitePlus 15755722
Q99814 (EPAS1) T324 HPRD 17024177
Q9BST9-2 (RTKN) S435 PhosphoSitePlus 22228765
Q9BST9 (RTKN) S448 neXtProt 22228765
Q9NRA0 (SPHK2) S419 PhosphoSitePlus 17635916
Q9NRA0 (SPHK2) S421 PhosphoSitePlus 17635916
Q9UBF8 (PI4KB) S294 neXtProt   PhosphoSitePlus   Signor 16912074, 16100512
Q9ULH0-1 (KIDINS220) S918 HPRD 18578522, 18669648, 20068231, ...10998417
Q9UQL6-1 (HDAC5) S259 HPRD   PhosphoSitePlus 11114197, 11081517, 15367659, ...18332134
Q9UQL6-3 (HDAC5) S260 HPRD 11114197, 11081517, 15367659
Q9UQL6 (HDAC5) S498 HPRD   neXtProt   PhosphoSitePlus   Signor 11081517, 21146494, 15367659, ...16584705, 22865920, 11114197, 18332134
Q9UQL6-3 (HDAC5) S499 HPRD 11114197, 11081517, 15367659
Q9Y3E5 (PTRH2) S5 neXtProt   PhosphoSitePlus   Signor 18703509
Q9Y3E5 (PTRH2) S87 neXtProt   PhosphoSitePlus   Signor 18703509
Q9Y5P4 (CERT1) S132 neXtProt   PhosphoSitePlus   Signor 21285358, 17591919