iPTMnet Report for Q15131 (CDK10)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15131 / CDK10_HUMAN
Protein Name Cyclin-dependent kinase 10
Gene Name Name: CDK10
Organism Homo sapiens (Human)

PRO ID PR:Q15131
DAG View
PRO Name cyclin-dependent kinase 10 (human)
Definition A cyclin-dependent kinase 10 that is encoded in the genome of human.
Short Label hCDK10
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15131 (CDK10) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T23 Phosphorylation IEDB 35494241
K41 Ubiquitination PhosphoSitePlus
T49 Phosphorylation PhosphoSitePlus
Y50 Phosphorylation PhosphoSitePlus
Y54 Phosphorylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
T133 Phosphorylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
T196 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 17192257
Y204 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T196 Phosphorylation HPRD 18691976, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T125 Phosphorylation HPRD 18691976, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T125 Phosphorylation HPRD 18691976, 18669648, 20068231
S249 Phosphorylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
Y251 Phosphorylation PhosphoSitePlus


Q15131 (CDK10) as PTM Enzyme



Substrate Site Score Source PMID
P15036 (ETS2) S220 PhosphoSitePlus   Signor 24218572
P15036 (ETS2) S225 PhosphoSitePlus   Signor 24218572


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K68 N68 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K76 T76 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S250 F250 Biomuta DOID:4159 / skin cancer [ cosmic ]