iPTMnet Report for Q15121 (PEA15)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15121 / PEA15_HUMAN
Protein Name Astrocytic phosphoprotein PEA-15
Gene Name Name: PEA15
Organism Homo sapiens (Human)

PRO ID PR:Q15121
DAG View
PRO Name astrocytic phosphoprotein PEA-15 (human)
Definition An astrocytic phosphoprotein PEA-15 that is encoded in the genome of human.
Short Label hPEA15
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15121 (PEA15) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y4 Phosphorylation PhosphoSitePlus
T6 Phosphorylation PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
S25 Phosphorylation PhosphoSitePlus
C27 S-Nitrosylation dbSNO 2212679, 22126794
K28 Ubiquitination PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus   UniProt 20068231
S90 Phosphorylation PhosphoSitePlus
T97 Phosphorylation PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
T100 Phosphorylation PhosphoSitePlus
S104 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 33246486, 21406692, 23552738, ...23186163, 17081983, 34997083, 30569123, 25096718, 15916534, 20452983, 15917297, 31396050, 34241740, 9721757, 20032303
S104 Phosphorylation P17252 (PRKCA) Signor 15917297
Y108 Phosphorylation PhosphoSitePlus
K109 Methylation PhosphoSitePlus
S116 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 34997083, 20452983, 15917297, ...21406692, 23186163, 23552738, 12808093, 24275569, 22105357, 18314633, 30569123, 17700518, 9721757, 33246486, 19382910, 17081983, 25096718, 15916534, 31396050, 34241740, 20068231, 20032303
S116 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 12808093
S116 Phosphorylation P54646 (PRKAA2) RLIMS-P+ 25096718
S116 Phosphorylation Q9UQM7 (CAMK2A) Signor 15916534
Site PTM Type PTM Enzyme Score Source PMID
Y4 Phosphorylation HPRD 18491316
T6 Phosphorylation HPRD 17287340
S25 Phosphorylation HPRD 17287340
S61 Phosphorylation HPRD 19651622, 20068231
S104 Phosphorylation HPRD 19651622, 17287340, 9721757, ...20068231
S104 Phosphorylation P17252 (PRKCA) HPRD 19651622, 17287340, 9721757, ...20068231
Y108 Phosphorylation HPRD 17287340
S116 Phosphorylation HPRD 19413330, 18578522, 17287340, ...18212344, 18767875, 19664995, 18452278, 19651622, 18669648, 12808093, 20166139, 9721757, 20068231
S116 Phosphorylation P31749 (AKT1) HPRD 19413330, 18578522, 17287340, ...18212344, 18767875, 19664995, 18452278, 19651622, 18669648, 12808093, 20166139, 9721757, 20068231
S116 Phosphorylation Q13555 (CAMK2G) HPRD 19413330, 18578522, 17287340, ...18212344, 18767875, 19664995, 18452278, 19651622, 18669648, 12808093, 20166139, 9721757, 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q15121 (PEA15) S104 P28482 (MAPK1) increased_association eFIP 15916534
Phosphorylation Q15121 (PEA15) S104 Q13158 (FADD) increased_association eFIP 15916534


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S43 N43 Biomuta DOID:4159 / skin cancer [ cosmic ]