Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15118 / PDK1_HUMAN
Protein Name [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial precursor
Gene Name Name: PDK1
Synonyms:PDHK1;
Organism Homo sapiens (Human)

PRO ID PR:Q15118
DAG View
PRO Name [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (human)
Definition A [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial that is encoded in the genome of human.
Short Label hPDK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15118 (PDK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S25 Phosphorylation phospho.ELM 12177059
S67 Phosphorylation PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
Y136 Phosphorylation P11362 (FGFR1) neXtProt   PhosphoSitePlus   Signor   UniProt 22195962
K230 Ubiquitination PhosphoSitePlus
Y243 Phosphorylation P11362 (FGFR1) , O60674 (JAK2) , P00519 (ABL1) , P36888 (FLT3) neXtProt   PhosphoSitePlus   Signor   UniProt 22195962
Y244 Phosphorylation P11362 (FGFR1) neXtProt   PhosphoSitePlus   Signor   UniProt 22195962
R319 Methylation PhosphoSitePlus
Y336 Phosphorylation PhosphoSitePlus
T338 Phosphorylation P00558 (PGK1) PhosphoSitePlus   RLIMS-P+   RLIMS-P 26942675
T346 Phosphorylation PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
Y357 Phosphorylation PhosphoSitePlus
S393 Phosphorylation phospho.ELM 12177059
S396 Phosphorylation phospho.ELM   RLIMS-P 15743829, 12177059
Y403 Phosphorylation PhosphoSitePlus
K405 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S25 Phosphorylation Q15118 (PDK1) HPRD 12177059
S393 Phosphorylation Q15118 (PDK1) HPRD 12177059
S396 Phosphorylation Q15118 (PDK1) HPRD 12177059


Q15118 (PDK1) as PTM Enzyme



Substrate Site Score Source PMID
P05106-1 (ITGB3) T779 HPRD 18578522, 10896934
P08559 (PDHA1) S232 HPRD   neXtProt   PhosphoSitePlus 18691976, 18088087, 18212344, ...18767875, 11486000, 15302935, 7782287, 22195962, 20058876, 20166139, 11092882, 11485553, 19415658, 20068231, 16436377
P08559 (PDHA1) S293 HPRD   neXtProt   PhosphoSitePlus 18691976, 16436377, 18767875, ...11486000, 12676647, 7782287, 22195962, 20166139, 11092882, 11485553, 19415658, 18212344
P08559 (PDHA1) S300 HPRD   neXtProt   PhosphoSitePlus 18691976, 16436377, 11486000, ...12676647, 7782287, 22195962, 20166139, 11092882, 11485553, 19415658, 18212344
P23443-1 (RPS6KB1) T390 HPRD 18669648, 11279232, 20068231
P29803 (PDHA2) S230 PhosphoSitePlus 16436377
P29803 (PDHA2) S291 neXtProt   PhosphoSitePlus   Signor 16436377
P29803 (PDHA2) S298 PhosphoSitePlus 16436377
P31749-1 (AKT1) T308 HPRD 11278835
P31749-1 (AKT1) S473 HPRD 11278835
P31751 (AKT2) T309 neXtProt 9512493
Q15118-1 (PDK1) S25 HPRD 12177059
Q15118-1 (PDK1) S393 HPRD 12177059
Q15118-1 (PDK1) S396 HPRD 12177059
Q16513 (PKN2) T816 HPRD   Signor 10753910, 18669648
Q16513-1 (PKN2) T951 HPRD 10753910
Q9Y243-1 (AKT3) S120 HPRD 9512493
Q9Y243 (AKT3) T305 neXtProt 9512493


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P31749 (AKT1) T308 Q15118 (PDK1) inhibited_association eFIP 22629392
Phosphorylation P31749 (AKT1) S473 Q15118 (PDK1) increased_association eFIP 27481935
Phosphorylation P31749 (AKT1) T308 Q15118 (PDK1) inhibited_association eFIP 22629392


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y244 C244 Biomuta DOID:4362 / cervical cancer [ tcga ]
R319 * Biomuta DOID:363 / uterine cancer [ tcga ]
R319 Q319 Biomuta DOID:363 / uterine cancer [ tcga ]
T338 S338 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
Y357 C357 Biomuta DOID:1324 / lung cancer [ cosmic ]