Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15116 / PDCD1_HUMAN
Protein Name Programmed cell death protein 1 precursor
Gene Name Name: PDCD1
Synonyms:PD1;
Organism Homo sapiens (Human)

PRO ID PR:Q15116
DAG View
PRO Name programmed cell death protein 1 (human)
Definition A programmed cell death protein 1 that is encoded in the genome of human.
Short Label hPDCD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15116 (PDCD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N49 N-Glycosylation GlyGen   UniProt 28165004
N58 N-Glycosylation GlyGen   UniProt 28165004
N74 N-Glycosylation GlyGen   UniProt 28165004, 24190977
N116 N-Glycosylation GlyGen   UniProt 28165004, 24190977
S159 Phosphorylation PhosphoSitePlus
Y223 Phosphorylation IntAct   PRO   PhosphoSitePlus 15240681
K233 Ubiquitination UniProt 30487606
Y248 Phosphorylation PRO   PhosphoSitePlus   RLIMS-P 32963251
S285 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048712 (hPDCD1/SigPep-/Phos:1) pY223,pY248 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q15116 (PDCD1) Y223 P29350 (PTPN6) unknown eFIP 15240681
Phosphorylation Q15116 (PDCD1) Y223 Q06124 (PTPN11) unknown eFIP 15240681


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N49 S49 Biomuta DOID:363 / uterine cancer [ icgc ]
K233 N233 Biomuta DOID:363 / uterine cancer [ tcga ]
S285 Y285 Biomuta DOID:9256 / colorectal cancer [ tcga ]