iPTMnet Report Q15109 AGER

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q15109 / RAGE_HUMAN
Protein Name	Advanced glycosylation end product-specific receptor precursor
Gene Name	Name: AGER Synonyms:RAGE;
Organism	Homo sapiens (Human)

PRO ID	PR:Q15109 DAG View
PRO Name	advanced glycosylation end product-specific receptor (human)
Definition	An advanced glycosylation end product-specific receptor that is encoded in the genome of human.
Short Label	hAGER
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q15109 (AGER) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	N25	N-Glycosylation		score2	GlyGen	21511948
	N81	N-Glycosylation		score3	GlyGen	21511948, 17714874
	K374	Ubiquitination		score1	PhosphoSitePlus
	S391	Phosphorylation		score3	PhosphoSitePlus RLIMS-P UniProt	21829704
	S399	Phosphorylation		score1	PhosphoSitePlus
	S400	Phosphorylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T271	Phosphorylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S148	Phosphorylation		score1	PhosphoSitePlus
	K150	Methylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T278	Phosphorylation		score1	PhosphoSitePlus
	T291	Phosphorylation		score1	PhosphoSitePlus

PTM-dependent PPI

	PTM type	Substrate	Site	Interactant	Association type	Source	PMID
	Phosphorylation	Q15109 (AGER)	S391	P58753 (TIRAP)	increased_association	eFIP	21829704
	Phosphorylation	Q15109 (AGER)	S391	Q99836 (MYD88)	increased_association	eFIP	32670078

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
N81	H81	Biomuta		DOID:2531 / hematologic cancer [ cosmic ]
S391	L391	Biomuta		DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ icgc ]