iPTMnet Report for Q15075 (EEA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15075 / EEA1_HUMAN
Protein Name Early endosome antigen 1
Gene Name Name: EEA1
Synonyms:ZFYVE2;
Organism Homo sapiens (Human)

PRO ID PR:Q15075
DAG View
PRO Name early endosome antigen 1 (human)
Definition An early endosome antigen 1 that is encoded in the genome of human.
Short Label hEEA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15075 (EEA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T9 Phosphorylation PhosphoSitePlus
S15 Phosphorylation HPRD   PhosphoSitePlus 18077418
S18 Phosphorylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
T25 Phosphorylation PhosphoSitePlus
S49 Phosphorylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus   UniProt 23186163
K58 Ubiquitination PhosphoSitePlus
S70 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
K81 Ubiquitination PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
S139 Phosphorylation PhosphoSitePlus
K158 Acetylation PhosphoSitePlus
K164 Acetylation PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
T212 O-Glycosylation GlyGen 30379171, 34019948, 30620550
K228 Ubiquitination PhosphoSitePlus
T235 Phosphorylation PhosphoSitePlus
T241 Phosphorylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
Y286 Phosphorylation PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
T301 Phosphorylation PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus
S356 Phosphorylation PhosphoSitePlus
S382 Phosphorylation PhosphoSitePlus
S421 Phosphorylation IEDB 35494241
K422 Ubiquitination PhosphoSitePlus
S540 O-Glycosylation GlyGen 30379171, 34019948, 30620550
K544 Ubiquitination PhosphoSitePlus
K552 Ubiquitination PhosphoSitePlus
T560 Phosphorylation PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
S618 Phosphorylation PhosphoSitePlus
T621 Phosphorylation PhosphoSitePlus
S628 Phosphorylation PhosphoSitePlus
K634 Acetylation PhosphoSitePlus
S638 Phosphorylation PhosphoSitePlus
K645 Acetylation PhosphoSitePlus
T761 Phosphorylation HPRD   PhosphoSitePlus 20068231
K824 Ubiquitination PhosphoSitePlus
T836 Phosphorylation HPRD 20068231
T837 Phosphorylation HPRD 20068231
K848 Methylation PhosphoSitePlus
T853 Phosphorylation PhosphoSitePlus
S856 Phosphorylation PhosphoSitePlus
T857 Phosphorylation PhosphoSitePlus
S863 Phosphorylation PhosphoSitePlus
K884 Ubiquitination PhosphoSitePlus
K895 Ubiquitination PhosphoSitePlus
T908 Phosphorylation PhosphoSitePlus
S918 Phosphorylation IEDB 35494241
S926 Phosphorylation PhosphoSitePlus
K995 Ubiquitination PhosphoSitePlus
S1015 Phosphorylation PhosphoSitePlus
Y1021 Phosphorylation PhosphoSitePlus
S1024 Phosphorylation PhosphoSitePlus
T1027 Phosphorylation PhosphoSitePlus
K1029 Ubiquitination PhosphoSitePlus
S1124 O-Glycosylation GlyGen 30379171, 34019948, 30620550
K1125 Ubiquitination PhosphoSitePlus
K1133 Acetylation PhosphoSitePlus
K1138 Acetylation PhosphoSitePlus
K1142 Acetylation PhosphoSitePlus
T1159 Phosphorylation PhosphoSitePlus
K1178 Ubiquitination PhosphoSitePlus
K1183 Ubiquitination PhosphoSitePlus
T1252 Phosphorylation PhosphoSitePlus
S1265 Phosphorylation PhosphoSitePlus
K1312 Ubiquitination PhosphoSitePlus
K1319 Ubiquitination PhosphoSitePlus
K1340 Ubiquitination PhosphoSitePlus
T1392 Phosphorylation HPRD   neXtProt   PhosphoSitePlus 16138080
T1392 Phosphorylation Q16539 (MAPK14) HPRD   neXtProt   PhosphoSitePlus 16138080


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S98 L98 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T212 S212 Biomuta DOID:1324 / lung cancer [ cosmic ]
T212 M212 Biomuta DOID:3571 / liver cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K228 E228 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
Y286 H286 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S540 L540 Biomuta DOID:1324 / lung cancer [ cosmic ]
K544 R544 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K552 T552 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K824 N824 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S863 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S1015 P1015 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]