iPTMnet Report for Q15054 (POLD3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15054 / DPOD3_HUMAN
Protein Name DNA polymerase delta subunit 3
Gene Name Name: POLD3
Synonyms:KIAA0039;
Organism Homo sapiens (Human)

PRO ID PR:Q15054
DAG View
PRO Name DNA polymerase delta subunit 3 (human)
Definition A DNA polymerase delta subunit 3 that is encoded in the genome of human.
Short Label hPOLD3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15054 (POLD3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22223895
Y42 Phosphorylation PhosphoSitePlus
Y44 Phosphorylation PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
T95 Phosphorylation PhosphoSitePlus
Y101 Phosphorylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
K131 Sumoylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
S133 Phosphorylation PhosphoSitePlus
T173 Phosphorylation PhosphoSitePlus
K203 Acetylation PhosphoSitePlus
T207 Phosphorylation PhosphoSitePlus
K216 Sumoylation PhosphoSitePlus
S222 Phosphorylation PhosphoSitePlus
K231 Sumoylation PhosphoSitePlus
K246 Acetylation PhosphoSitePlus
K248 Methylation PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
K258 Sumoylation PhosphoSitePlus
S269 O-Glycosylation GlyGen 30379171, 31373491
T271 O-Glycosylation GlyGen 31373491
K274 Sumoylation PhosphoSitePlus
T277 Phosphorylation PhosphoSitePlus   UniProt 23186163
K282 Acetylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
K286 Acetylation PhosphoSitePlus
K287 Acetylation PhosphoSitePlus
K298 Acetylation PhosphoSitePlus
K302 Acetylation PhosphoSitePlus
S307 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 19369195, 18669648, 20068231
T311 Phosphorylation PhosphoSitePlus
T314 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus
S407 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S409 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T411 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S413 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S423 Phosphorylation PhosphoSitePlus
K433 Sumoylation PhosphoSitePlus
K444 Acetylation PhosphoSitePlus
K452 Acetylation PhosphoSitePlus
S458 O-Glycosylation GlyGen 30379171, 31373491
S458 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor   UniProt 22148433, 18669648, 23186163
S458 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 22148433
Site PTM Type PTM Enzyme Score Source PMID
T277 Phosphorylation HPRD 19413330
S307 Phosphorylation HPRD 19413330, 18691976, 18212344, ...18767875, 19651622, 19007248, 18452278, 17322306, 18669648, 19415658, 20068231
T311 Phosphorylation HPRD 17081983
S407 Phosphorylation HPRD 18669648, 17081983
S409 Phosphorylation HPRD 18669648, 17081983
T411 Phosphorylation HPRD 18669648, 17081983
S413 Phosphorylation HPRD 18669648, 17081983
S458 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 T2 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S133 C133 Biomuta DOID:263 / kidney cancer [ cosmic ]
S253 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S253 L253 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K302 T302 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S413 R413 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K433 E433 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]