iPTMnet Report for Q15052 (ARHGEF6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15052 / ARHG6_HUMAN
Protein Name Rho guanine nucleotide exchange factor 6
Gene Name Name: ARHGEF6
Synonyms:COOL2,KIAA0006,PIXA;
Organism Homo sapiens (Human)

PRO ID PR:Q15052
DAG View
PRO Name Rho guanine nucleotide exchange factor 6 (human)
Definition A Rho guanine nucleotide exchange factor 6 that is encoded in the genome of human.
Short Label hARHGEF6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15052 (ARHGEF6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K22 Ubiquitination PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
Y91 Phosphorylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
S122 Phosphorylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus   UniProt 19690332
S131 Phosphorylation PhosphoSitePlus
T133 Phosphorylation PhosphoSitePlus   UniProt 24275569
S144 Phosphorylation PhosphoSitePlus   UniProt 19690332
S150 Phosphorylation PhosphoSitePlus   UniProt 19690332, 15144186
K151 Ubiquitination PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
Y188 Phosphorylation PhosphoSitePlus
T201 O-Glycosylation GlyGen 29351928
S225 Phosphorylation Q04759 (PRKCQ) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 25694429, 24275569, 16094384
K227 Ubiquitination PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
T243 O-Glycosylation GlyGen 29351928
K254 Ubiquitination PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
Y470 Phosphorylation PhosphoSitePlus
S488 Phosphorylation Q04759 (PRKCQ) phospho.ELM   PhosphoSitePlus   RLIMS-P 25694429, 15659558, 16964243, ...18220336, 15302935, 18669648
Y492 Phosphorylation PhosphoSitePlus
K495 Ubiquitination PhosphoSitePlus
T504 Phosphorylation PhosphoSitePlus
S552 Phosphorylation PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
S561 Phosphorylation PhosphoSitePlus
S562 Phosphorylation PhosphoSitePlus
S565 Phosphorylation PhosphoSitePlus
S569 Phosphorylation PhosphoSitePlus
T573 Phosphorylation PhosphoSitePlus
S592 Phosphorylation PhosphoSitePlus
Y608 Phosphorylation PhosphoSitePlus
S613 Phosphorylation PhosphoSitePlus
Y614 Phosphorylation PhosphoSitePlus
K617 Ubiquitination PhosphoSitePlus
S622 Phosphorylation PhosphoSitePlus
K627 Acetylation PhosphoSitePlus
T635 Phosphorylation PhosphoSitePlus
K638 Ubiquitination PhosphoSitePlus
S640 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor   UniProt 26507661, 19690332
Y644 Phosphorylation PhosphoSitePlus
K648 Ubiquitination PhosphoSitePlus
S649 Phosphorylation PhosphoSitePlus
T650 Phosphorylation PhosphoSitePlus
K661 Ubiquitination PhosphoSitePlus
Y666 Phosphorylation PhosphoSitePlus
S669 Phosphorylation PhosphoSitePlus
K682 Ubiquitination PhosphoSitePlus
S684 Phosphorylation P17612 (PRKACA) , Q13976 (PRKG1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 26507661, 23186163, 16094384, ...24275569, 19690332
K695 Ubiquitination PhosphoSitePlus
T701 Phosphorylation PhosphoSitePlus
S703 Phosphorylation PhosphoSitePlus
K712 Ubiquitination PhosphoSitePlus
S713 Phosphorylation PhosphoSitePlus
T717 Phosphorylation PhosphoSitePlus
Y719 Phosphorylation PhosphoSitePlus
K722 Ubiquitination PhosphoSitePlus
K736 Ubiquitination PhosphoSitePlus
K751 Acetylation PhosphoSitePlus
K758 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S122 Phosphorylation HPRD 15144186
S123 Phosphorylation HPRD 15144186
S124 Phosphorylation HPRD 15144186
S126 Phosphorylation HPRD 15144186
S150 Phosphorylation HPRD 15144186
S225 Phosphorylation HPRD 16094384
S454 Phosphorylation HPRD 20068231
Y470 Phosphorylation HPRD 20068231
S482 Phosphorylation HPRD 20068231
S484 Phosphorylation HPRD 20068231
S488 Phosphorylation HPRD 18578522, 20058876, 16964243, ...18767875, 15302935, 19664994, 18669648, 20166139, 19415658, 20068231
S592 Phosphorylation HPRD 18491316
S640 Phosphorylation HPRD 20166139
S649 Phosphorylation HPRD 17081983, 20068231
T650 Phosphorylation HPRD 17081983, 20068231
S684 Phosphorylation HPRD 19413330, 20166139, 20058876, ...15144186


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K22 N22 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S131 T131 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K151 N151 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
Y188 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T243 N243 Biomuta DOID:363 / uterine cancer [ icgc ]
K254 E254 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K254 N254 Biomuta DOID:363 / uterine cancer [ icgc ]
K382 T382 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K412 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K412 N412 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S454 P454 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y470 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y470 H470 Biomuta DOID:363 / uterine cancer [ icgc ]
S488 R488 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T504 N504 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S561 L561 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
T573 I573 Biomuta DOID:3571 / liver cancer [ cosmic ]
S613 Y613 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K617 M617 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K627 R627 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K627 N627 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K638 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T650 S650 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S684 C684 Biomuta DOID:263 / kidney cancer [ cosmic ]
T701 S701 Biomuta DOID:263 / kidney cancer [ cosmic ]
S703 N703 Biomuta DOID:4159 / skin cancer [ cosmic ]
K736 N736 Biomuta DOID:9256 / colorectal cancer [ cosmic ]