iPTMnet Report for Q15047 (SETDB1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15047 / SETB1_HUMAN
Protein Name Histone-lysine N-methyltransferase SETDB1
Gene Name Name: SETDB1
Synonyms:ESET;
Organism Homo sapiens (Human)

PRO ID PR:Q15047
DAG View
PRO Name histone-lysine N-methyltransferase SETDB1 (human)
Definition A histone-lysine N-methyltransferase SETDB1 that is encoded in the genome of human.
Short Label hSETDB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15047 (SETDB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K59 Ubiquitination PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
S137 Phosphorylation PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
K173 Acetylation PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
Y230 Phosphorylation PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
Y311 Phosphorylation IEDB 35494241
K319 Ubiquitination PhosphoSitePlus
T338 Phosphorylation PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus
K355 Sumoylation PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
S468 Phosphorylation PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus
K490 Methylation PhosphoSitePlus
R495 Methylation PhosphoSitePlus
S501 Phosphorylation PhosphoSitePlus
S504 Phosphorylation PhosphoSitePlus
S505 Phosphorylation PhosphoSitePlus
T507 Phosphorylation PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus
K570 Ubiquitination PhosphoSitePlus
S579 Phosphorylation PhosphoSitePlus
K597 Ubiquitination PhosphoSitePlus
Y627 Phosphorylation PhosphoSitePlus
Y673 Phosphorylation PhosphoSitePlus
Y677 Phosphorylation PhosphoSitePlus
Y678 Phosphorylation PhosphoSitePlus
K715 Ubiquitination PhosphoSitePlus
Y779 Phosphorylation PhosphoSitePlus
K786 Acetylation PhosphoSitePlus
K786 Ubiquitination PhosphoSitePlus
K809 Acetylation PhosphoSitePlus
K809 Ubiquitination PhosphoSitePlus
K813 Ubiquitination PhosphoSitePlus
C830 Methylation IEDB 31844290
T838 Phosphorylation phospho.ELM   PhosphoSitePlus 16097034
S862 Phosphorylation PhosphoSitePlus
K867 Sumoylation PhosphoSitePlus
K867 Ubiquitination PhosphoSitePlus
S872 Phosphorylation PhosphoSitePlus
S905 Phosphorylation PhosphoSitePlus
S906 Phosphorylation PhosphoSitePlus
S917 Phosphorylation PhosphoSitePlus
S920 Phosphorylation PhosphoSitePlus
T976 Phosphorylation neXtProt 17952062
T976 Phosphorylation Q9UBE8 (NLK) neXtProt 17952062
S1025 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1027 Phosphorylation PhosphoSitePlus
K1032 Sumoylation PhosphoSitePlus
K1042 Ubiquitination PhosphoSitePlus
T1045 Phosphorylation PhosphoSitePlus
K1050 Ubiquitination PhosphoSitePlus
S1066 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18220336, ...18847512, 18669648
S1066 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
K1069 Sumoylation PhosphoSitePlus
S1078 Phosphorylation PhosphoSitePlus
T1080 Phosphorylation PhosphoSitePlus
T1101 Phosphorylation PhosphoSitePlus
S1103 Phosphorylation PhosphoSitePlus
S1104 Phosphorylation PhosphoSitePlus
T1106 Phosphorylation PhosphoSitePlus
S1108 Phosphorylation PhosphoSitePlus
T1119 Phosphorylation PhosphoSitePlus
T1123 Phosphorylation PhosphoSitePlus
S1130 Phosphorylation PhosphoSitePlus
T1135 Phosphorylation PhosphoSitePlus
S1137 Phosphorylation PhosphoSitePlus
S1138 Phosphorylation PhosphoSitePlus
S1140 Phosphorylation PhosphoSitePlus
K1149 Sumoylation PhosphoSitePlus
T1152 Phosphorylation PhosphoSitePlus
K1162 Methylation PhosphoSitePlus
S1163 Phosphorylation PhosphoSitePlus
K1170 Methylation PhosphoSitePlus   UniProt 24129315
K1178 Methylation PhosphoSitePlus   UniProt 24129315
K1178 Ubiquitination PhosphoSitePlus
S1179 Phosphorylation phospho.ELM 17287340
T1180 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S1184 Phosphorylation PhosphoSitePlus
K1187 Ubiquitination PhosphoSitePlus
S1190 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
T1197 Phosphorylation PhosphoSitePlus
S1271 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S1066 Phosphorylation HPRD 17322306, 19651622, 18669648, ...19664995, 20068231
T1180 Phosphorylation HPRD 17287340
S1190 Phosphorylation HPRD 17287340
T1197 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K102 T102 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S137 * Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
K257 E257 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K257 N257 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y311 C311 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K319 M319 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S468 F468 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R495 G495 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
R495 * Biomuta [ cosmic ] DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S501 F501 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S504 C504 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S528 L528 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y673 C673 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y678 S678 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K715 E715 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y779 * Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y779 F779 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K813 Q813 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S905 R905 Biomuta DOID:363 / uterine cancer [ icgc ]
S906 P906 Biomuta DOID:9256 / colorectal cancer [ cosmic, cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S906 L906 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1027 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1027 L1027 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K1050 N1050 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1066 P1066 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K1069 N1069 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S1137 F1137 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1149 N1149 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
K1162 N1162 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K1170 E1170 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1179 L1179 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T1180 P1180 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1190 N1190 Biomuta DOID:9256 / colorectal cancer [ cosmic ]