Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15046 / SYK_HUMAN
Protein Name Lysine--tRNA ligase
Gene Name Name: KARS1
Synonyms:KARS,KIAA0070;
Organism Homo sapiens (Human)

PRO ID PR:Q15046
DAG View
PRO Name lysine--tRNA ligase (human)
Definition A eukaryote-type lysine--tRNA ligase that is encoded in the genome of human.
Short Label hKARS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15046 (KARS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895
K10 Ubiquitination PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
K31 Acetylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
S49 Phosphorylation PhosphoSitePlus
T52 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 22751010
K78 Ubiquitination PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
K88 Acetylation PhosphoSitePlus   UniProt 19608861
K88 Methylation PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K141 Acetylation PhosphoSitePlus   UniProt 19608861
K141 Ubiquitination PhosphoSitePlus
R148 Methylation PhosphoSitePlus
K164 Acetylation PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K175 Acetylation PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
S207 Phosphorylation P27361 (MAPK3) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 29029422, 28814526, 30546840, ...19524539, 28394346
K249 Ubiquitination PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
R314 Methylation PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
T366 Phosphorylation PhosphoSitePlus
K370 Acetylation PhosphoSitePlus
K402 Acetylation PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
T416 O-Glycosylation GlyGen 20305658, 29351928, 21740066, ...32119511
T419 O-Glycosylation GlyGen 20305658, 29351928, 21740066, ...32119511
K421 Ubiquitination PhosphoSitePlus
K430 Ubiquitination PhosphoSitePlus
S470 Phosphorylation PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
K517 Ubiquitination PhosphoSitePlus
S561 Phosphorylation PhosphoSitePlus
K578 Ubiquitination PhosphoSitePlus
T587 Phosphorylation PhosphoSitePlus
S590 Phosphorylation PhosphoSitePlus
S596 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S596 Phosphorylation HPRD 19413330
Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S44 N44 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R148 Q148 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K249 N249 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S470 N470 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K492 N492 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T587 K587 Biomuta DOID:263 / kidney cancer [ tcga ]