iPTMnet Report for Q15034 (HERC3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15034 / HERC3_HUMAN
Protein Name Probable E3 ubiquitin-protein ligase HERC3
Gene Name Name: HERC3
Synonyms:KIAA0032;
Organism Homo sapiens (Human)

PRO ID PR:Q15034
DAG View
PRO Name probable E3 ubiquitin-protein ligase HERC3 (human)
Definition A probable E3 ubiquitin-protein ligase HERC3 that is encoded in the genome of human.
Short Label hHERC3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15034 (HERC3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K37 Ubiquitination PhosphoSitePlus
C58 Methylation IEDB 31844290
K63 Ubiquitination PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
C234 Methylation IEDB 31844290
K237 Ubiquitination PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
C301 Methylation IEDB 31844290
K336 Ubiquitination PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
Y361 Phosphorylation PhosphoSitePlus
T374 Phosphorylation PhosphoSitePlus
K444 Ubiquitination PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
K454 Ubiquitination PhosphoSitePlus
K599 Acetylation IEDB 34357683
K662 Ubiquitination PhosphoSitePlus
K816 Ubiquitination PhosphoSitePlus
K821 Ubiquitination PhosphoSitePlus
S863 Phosphorylation PhosphoSitePlus
Y864 Phosphorylation PhosphoSitePlus
K871 Ubiquitination PhosphoSitePlus
T880 Phosphorylation PhosphoSitePlus
Y896 Phosphorylation PhosphoSitePlus
Y906 Phosphorylation PhosphoSitePlus
K920 Ubiquitination PhosphoSitePlus
T985 Phosphorylation PhosphoSitePlus
K1030 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C58 * Biomuta DOID:363 / uterine cancer [ cosmic ]
K336 N336 Biomuta DOID:1324 / lung cancer [ cosmic ]
T374 A374 Biomuta DOID:3571 / liver cancer [ cosmic ]
T985 K985 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]