Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15031 / SYLM_HUMAN
Protein Name Probable leucine--tRNA ligase, mitochondrial precursor
Gene Name Name: LARS2
Synonyms:KIAA0028;
Organism Homo sapiens (Human)

PRO ID PR:Q15031
DAG View
PRO Name probable leucine--tRNA ligase, mitochondrial (human)
Definition A probable leucine--tRNA ligase, mitochondrial that is encoded in the genome of human.
Short Label hLARS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15031 (LARS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S39 Phosphorylation PhosphoSitePlus
Y41 Phosphorylation PhosphoSitePlus
S42 Phosphorylation PhosphoSitePlus
Y85 Phosphorylation HPRD   PhosphoSitePlus 20058876
S88 Phosphorylation HPRD   PhosphoSitePlus 20058876
S108 Phosphorylation PhosphoSitePlus
T110 Phosphorylation PhosphoSitePlus
K155 Acetylation PhosphoSitePlus
Y199 Phosphorylation PhosphoSitePlus
K236 Acetylation PhosphoSitePlus   UniProt 19608861
S315 Phosphorylation PhosphoSitePlus
T343 Phosphorylation PhosphoSitePlus
T352 Phosphorylation PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
K600 Ubiquitination PhosphoSitePlus
Y611 Phosphorylation HPRD   PhosphoSitePlus 20068231
K628 Ubiquitination PhosphoSitePlus
T636 Phosphorylation PhosphoSitePlus
S711 Phosphorylation PhosphoSitePlus   UniProt 23186163
S873 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y41 N41 Biomuta DOID:2394 / ovarian cancer [ tcga ]
Y85 C85 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K155 T155 Biomuta DOID:363 / uterine cancer [ tcga ]
S315 L315 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T343 A343 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T636 M636 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ] DOID:9256 / colorectal cancer [ tcga ]