iPTMnet Report for Q15024 (EXOSC7)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15024 / EXOS7_HUMAN
Protein Name Exosome complex component RRP42
Gene Name Name: EXOSC7
Synonyms:KIAA0116,RRP42;
Organism Homo sapiens (Human)

PRO ID PR:Q15024
DAG View
PRO Name exosome complex component RRP42 (human)
Definition An exosome complex component RRP42 that is encoded in the genome of human.
Short Label hEXOSC7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15024 (EXOSC7) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22223895
T5 Phosphorylation HPRD 20068231
K11 Ubiquitination PhosphoSitePlus
C29 Methylation IEDB 31844290
C34 S-Nitrosylation dbSNO 26338901
K52 Ubiquitination PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
K116 Acetylation PhosphoSitePlus   UniProt 19608861
K116 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
S177 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163
K178 Ubiquitination PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
C189 S-Nitrosylation dbSNO 26338901
S193 Phosphorylation PhosphoSitePlus
T202 Phosphorylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
T258 Phosphorylation HPRD   PhosphoSitePlus 20068231
K260 Ubiquitination PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T5 A5 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
K122 N122 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S193 C193 Biomuta DOID:3571 / liver cancer [ cosmic ]
S251 R251 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]