iPTMnet Report for Q15019 (SEPTIN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15019 / SEPT2_HUMAN
Protein Name Septin-2
Gene Name Name: SEPTIN2
Synonyms:DIFF6,KIAA0158,NEDD5,SEPT2;
Organism Homo sapiens (Human)

PRO ID PR:Q15019
DAG View
PRO Name septin-2 (human)
Definition A septin-2 that is encoded in the genome of human.
Short Label hSEPTIN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15019 (SEPTIN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K3 Ubiquitination PhosphoSitePlus
T7 Phosphorylation PhosphoSitePlus
T14 Phosphorylation PhosphoSitePlus
Y17 Phosphorylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
T78 Phosphorylation PhosphoSitePlus
R96 Methylation PhosphoSitePlus
C111 S-Nitrosylation dbSNO 2212679, 22126794
K116 Ubiquitination PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K190 Acetylation PhosphoSitePlus   UniProt 19608861
K190 Ubiquitination PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
Y211 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18083107, 23186163
S218 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18691976, 21406692, 18088087, ...17081983, 18220336, 19165576, 15150837, 18318008, 16857012, 18669648, 17287340, 24275569, 19369195, 23186163, 16565220, 19690332, 20068231
S218 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor 16857012
K225 Ubiquitination PhosphoSitePlus
T228 Phosphorylation PhosphoSitePlus
K232 Acetylation PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
T291 Phosphorylation PhosphoSitePlus
Y296 Phosphorylation PhosphoSitePlus
K310 Ubiquitination PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
K325 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y17 Phosphorylation HPRD 15592455, 19901323
S134 Phosphorylation HPRD 20068231
Y211 Phosphorylation HPRD 18083107
S218 Phosphorylation HPRD 19413330, 18691976, 18578522, ...18491316, 18088087, 18212344, 20230923, 19562805, 18767875, 19664995, 18452278, 19651622, 18510355, 18669648, 18707149, 20166139, 17287340, 16565220, 19415658, 20068231, 17924679
T228 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T7 A7 Biomuta DOID:3571 / liver cancer [ cosmic ]
R96 C96 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R96 H96 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
K116 R116 Biomuta DOID:1319 / brain cancer [ cosmic ]
S120 P120 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S134 R134 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S134 G134 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K225 T225 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y296 C296 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K310 T310 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K318 R318 Biomuta DOID:1319 / brain cancer [ icgc ]