iPTMnet Report for Q15005 (SPCS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15005 / SPCS2_HUMAN
Protein Name Signal peptidase complex subunit 2
Gene Name Name: SPCS2
Synonyms:KIAA0102,SPC25;
Organism Homo sapiens (Human)

PRO ID PR:Q15005
DAG View
PRO Name signal peptidase complex subunit 2 (human)
Definition A signal peptidase complex subunit 2 that is encoded in the genome of human.
Short Label hSPCS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15005 (SPCS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 34388369, 22814378, ...25944712
S14 O-Glycosylation GlyGen 29485866, 29351928, 34725712, ...28510447
C17 S-Nitrosylation dbSNO 26338901
S24 Phosphorylation PhosphoSitePlus
C26 S-Nitrosylation dbSNO 26338901
S33 O-Glycosylation GlyGen 29485866, 29351928, 34725712, ...28510447
S33 Phosphorylation PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
K71 Acetylation PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
T149 Phosphorylation HPRD   PhosphoSitePlus 20068231
K164 Ubiquitination PhosphoSitePlus
K169 Acetylation PhosphoSitePlus   UniProt 19608861
K169 Ubiquitination PhosphoSitePlus
T175 Phosphorylation PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
K191 Acetylation PhosphoSitePlus   UniProt 19608861
K191 Ubiquitination PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
K195 Acetylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
Y208 Phosphorylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 V2 Biomuta DOID:4362 / cervical cancer [ icgc ]
C17 Y17 Biomuta DOID:4159 / skin cancer [ cosmic ]
C17 S17 Biomuta DOID:3571 / liver cancer [ cosmic ]
K47 Q47 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K57 T57 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K57 I57 Biomuta DOID:363 / uterine cancer [ icgc ]
K71 T71 Biomuta DOID:363 / uterine cancer [ icgc ]