iPTMnet Report for Q14C86 (GAPVD1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14C86 / GAPD1_HUMAN
Protein Name GTPase-activating protein and VPS9 domain-containing protein 1
Gene Name Name: GAPVD1
Synonyms:GAPEX5,KIAA1521,RAP6;
Organism Homo sapiens (Human)

PRO ID PR:Q14C86
DAG View
PRO Name GTPase-activating protein and VPS9 domain-containing protein 1 (human)
Definition A GTPase-activating protein and VPS9 domain-containing protein 1 that is encoded in the genome of human.
Short Label hGAPVD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14C86 (GAPVD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K3 Ubiquitination PhosphoSitePlus
K24 Acetylation PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
T80 Phosphorylation PhosphoSitePlus
Y86 Phosphorylation PhosphoSitePlus
T94 Phosphorylation PhosphoSitePlus
Y96 Phosphorylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
C176 Methylation IEDB 31844290
S227 Phosphorylation PhosphoSitePlus   UniProt 23186163
K233 Ubiquitination PhosphoSitePlus
K238 Acetylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
K270 Acetylation PhosphoSitePlus
Y288 Phosphorylation PhosphoSitePlus
S356 Phosphorylation PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
T390 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 16964243, ...32356940, 18669648, 20068231
S394 Phosphorylation PhosphoSitePlus
S395 Phosphorylation PhosphoSitePlus
S454 Phosphorylation PhosphoSitePlus
T458 Phosphorylation PhosphoSitePlus   UniProt 18669648
Y460 Phosphorylation PhosphoSitePlus   UniProt 32356940
T462 Phosphorylation PhosphoSitePlus
S466 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
T469 Phosphorylation PhosphoSitePlus
T470 Phosphorylation PhosphoSitePlus   UniProt 18669648
T562 Phosphorylation PhosphoSitePlus
S566 Phosphorylation PhosphoSitePlus   UniProt 18669648
S569 Phosphorylation PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus
S580 Phosphorylation PhosphoSitePlus
S722 Phosphorylation PhosphoSitePlus
S740 Phosphorylation PhosphoSitePlus
C741 S-Nitrosylation dbSNO 26338901
S742 Phosphorylation PhosphoSitePlus
S746 Phosphorylation PhosphoSitePlus   UniProt 23186163
T747 Phosphorylation PhosphoSitePlus
S748 Phosphorylation PhosphoSitePlus
S757 Phosphorylation PhosphoSitePlus   UniProt 24275569
S758 Phosphorylation PhosphoSitePlus
S761 Phosphorylation PhosphoSitePlus
T762 Phosphorylation PhosphoSitePlus   UniProt 24275569
S766 Phosphorylation PhosphoSitePlus   UniProt 19690332
S769 Phosphorylation PhosphoSitePlus
T774 Phosphorylation PhosphoSitePlus
S787 Phosphorylation PhosphoSitePlus
S790 Phosphorylation PhosphoSitePlus
S791 Phosphorylation PhosphoSitePlus
Y847 Phosphorylation PhosphoSitePlus
S876 Phosphorylation PhosphoSitePlus   UniProt 23186163
T880 Phosphorylation PhosphoSitePlus
S892 Phosphorylation PhosphoSitePlus
R896 Methylation PhosphoSitePlus
S900 Phosphorylation PhosphoSitePlus
S902 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 32356940, ...18669648, 19690332, 20068231
S903 Phosphorylation PhosphoSitePlus   UniProt 32356940, 18669648, 23186163
S907 O-Glycosylation GlyGen 31373491
S908 Phosphorylation PhosphoSitePlus
S914 Phosphorylation PhosphoSitePlus   UniProt 32356940
S917 Phosphorylation PhosphoSitePlus
S939 Phosphorylation PhosphoSitePlus
S946 O-Glycosylation GlyGen 30379171, 29351928, 31373491, ...34019948, 28510447, 34229054
S946 Phosphorylation PhosphoSitePlus
S947 Phosphorylation PhosphoSitePlus
S948 Phosphorylation PhosphoSitePlus
S949 O-Glycosylation GlyGen 31373491
S949 Phosphorylation PhosphoSitePlus
S950 Phosphorylation P06493 (CDK1) PhosphoSitePlus 18234856
S952 Phosphorylation PhosphoSitePlus
S955 Phosphorylation PhosphoSitePlus
S956 Phosphorylation PhosphoSitePlus
S966 Phosphorylation PhosphoSitePlus   UniProt 20068231
S984 Phosphorylation PhosphoSitePlus
S1012 Phosphorylation PhosphoSitePlus
T1013 Phosphorylation PhosphoSitePlus
T1015 Phosphorylation PhosphoSitePlus
S1019 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 16964243, ...18669648, 20068231
S1023 Phosphorylation PhosphoSitePlus
K1035 Ubiquitination PhosphoSitePlus
Y1036 Phosphorylation PhosphoSitePlus
T1043 Phosphorylation PhosphoSitePlus
S1044 Phosphorylation PhosphoSitePlus
Y1053 Phosphorylation PhosphoSitePlus
T1056 Phosphorylation PhosphoSitePlus
S1065 Phosphorylation PhosphoSitePlus
S1066 Phosphorylation PhosphoSitePlus
Y1070 Phosphorylation PhosphoSitePlus
S1072 Phosphorylation PhosphoSitePlus
S1096 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...18220336
S1103 Phosphorylation PhosphoSitePlus   UniProt 32356940
S1105 Phosphorylation PhosphoSitePlus
S1113 Phosphorylation PhosphoSitePlus
T1184 Phosphorylation PhosphoSitePlus
K1198 Ubiquitination PhosphoSitePlus
K1274 Ubiquitination PhosphoSitePlus
K1327 Ubiquitination PhosphoSitePlus
K1353 Ubiquitination PhosphoSitePlus
K1388 Ubiquitination PhosphoSitePlus
T1389 Phosphorylation PhosphoSitePlus
K1393 Ubiquitination PhosphoSitePlus
T1473 Phosphorylation IEDB 35494241
Site PTM Type PTM Enzyme Score Source PMID
S1017 Phosphorylation PhosphoSitePlus
S1019 Phosphorylation PhosphoSitePlus
S1037 Phosphorylation PhosphoSitePlus
S1041 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S801 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S112 Phosphorylation HPRD 20068231
S113 Phosphorylation HPRD 20068231
S147 Phosphorylation HPRD 20068231
T390 Phosphorylation HPRD 18691976, 18669648, 15302935, ...16964243, 20068231
S453 Phosphorylation HPRD 18669648
S454 Phosphorylation HPRD 18669648
T458 Phosphorylation HPRD 18669648
Y460 Phosphorylation HPRD 19901323, 18669648
T462 Phosphorylation HPRD 18669648
S466 Phosphorylation HPRD 19413330, 18669648, 20068231
T469 Phosphorylation HPRD 19413330, 18669648
T470 Phosphorylation HPRD 18669648
S566 Phosphorylation HPRD 18669648
S569 Phosphorylation HPRD 18669648
S742 Phosphorylation HPRD 18669648
S746 Phosphorylation HPRD 18669648
T747 Phosphorylation HPRD 19413330, 18669648
S748 Phosphorylation HPRD 19413330
S757 Phosphorylation HPRD 19651622, 18669648, 20068231, ...20230923
S758 Phosphorylation HPRD 20068231, 20230923
S761 Phosphorylation HPRD 19651622, 20068231, 20230923
T762 Phosphorylation HPRD 18669648, 20230923
S766 Phosphorylation HPRD 20230923
S769 Phosphorylation HPRD 18669648
S801 Phosphorylation PhosphoSitePlus
Y813 Phosphorylation PhosphoSitePlus
S927 Phosphorylation HPRD 19651622, 18691976, 18669648
S929 Phosphorylation HPRD 19651622, 18669648, 18212344, ...20068231, 19691289
S930 Phosphorylation HPRD 19651622, 18669648
S941 Phosphorylation HPRD 20068231
S966 Phosphorylation HPRD 18669648, 20068231
S973 Phosphorylation HPRD 18669648
S974 Phosphorylation HPRD 18669648, 20068231
S975 Phosphorylation HPRD 18669648
S977 Phosphorylation HPRD 18669648, 20068231
S979 Phosphorylation HPRD 19651622, 18669648, 20068231
S982 Phosphorylation HPRD 18669648
S983 Phosphorylation HPRD 18669648
S993 Phosphorylation HPRD 19651622, 20068231
S1046 Phosphorylation HPRD 19413330, 18691976, 16964243, ...19664994, 19691289, 18669648, 19415658, 20068231
T1070 Phosphorylation HPRD 20068231
S1071 Phosphorylation PhosphoSitePlus
S1073 Phosphorylation HPRD   PhosphoSitePlus 18669648
T1083 Phosphorylation HPRD 18707149
S1091 Phosphorylation PhosphoSitePlus
S1095 Phosphorylation PhosphoSitePlus
S1105 Phosphorylation HPRD 19651622, 18669648, 20068231
S1114 Phosphorylation HPRD 19651622, 17525332, 18669648
T1236 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S66 F66 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y86 H86 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y86 C86 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S101 N101 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K270 R270 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S394 Y394 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S395 P395 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S580 * Biomuta DOID:263 / kidney cancer [ cosmic ]
S580 L580 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S740 G740 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T747 I747 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S757 T757 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S791 F791 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
Y847 N847 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T880 S880 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S892 Y892 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R896 I896 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S955 P955 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S956 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
S982 P982 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S983 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
S1037 R1037 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T1056 R1056 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T1083 R1083 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S1091 R1091 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
T1389 P1389 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
T1473 I1473 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]