iPTMnet Report for Q149N8 (SHPRH)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q149N8 / SHPRH_HUMAN
Protein Name E3 ubiquitin-protein ligase SHPRH
Gene Name Name: SHPRH
Synonyms:KIAA2023;
Organism Homo sapiens (Human)

PRO ID PR:Q149N8
DAG View
PRO Name E3 ubiquitin-protein ligase SHPRH (human)
Definition An E3 ubiquitin-protein ligase SHPRH that is encoded in the genome of human.
Short Label hSHPRH
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q149N8 (SHPRH) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S37 Phosphorylation PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
K81 Acetylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus   UniProt 21406692
Y277 Phosphorylation PhosphoSitePlus
Y351 Phosphorylation PhosphoSitePlus
T352 Phosphorylation PhosphoSitePlus
K379 Acetylation PhosphoSitePlus
K423 Sumoylation PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
K512 Ubiquitination PhosphoSitePlus
S530 Phosphorylation PhosphoSitePlus
S597 Phosphorylation PhosphoSitePlus
T610 Phosphorylation PhosphoSitePlus
Y691 Phosphorylation PhosphoSitePlus
C727 Methylation IEDB 31844290
S787 Phosphorylation PhosphoSitePlus
S789 Phosphorylation PhosphoSitePlus
K830 Ubiquitination PhosphoSitePlus
S839 Phosphorylation PhosphoSitePlus
K951 Methylation PhosphoSitePlus
Y972 Phosphorylation PhosphoSitePlus
K1010 Ubiquitination PhosphoSitePlus
K1062 Ubiquitination PhosphoSitePlus
K1176 Acetylation PhosphoSitePlus
K1256 Ubiquitination PhosphoSitePlus
S1306 Phosphorylation PhosphoSitePlus
K1391 Ubiquitination PhosphoSitePlus
K1396 Ubiquitination PhosphoSitePlus
K1405 Ubiquitination PhosphoSitePlus
K1422 Ubiquitination PhosphoSitePlus
S1488 Phosphorylation PhosphoSitePlus
S1493 Phosphorylation PhosphoSitePlus
K1495 Acetylation PhosphoSitePlus
K1562 Ubiquitination PhosphoSitePlus
K1572 Ubiquitination PhosphoSitePlus
K1647 Ubiquitination PhosphoSitePlus
T1676 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S37 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S93 Phosphorylation HPRD 20068231
S266 Phosphorylation HPRD 18452278
S597 Phosphorylation HPRD 18077418
S1310 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K423 R423 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K512 N512 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C727 F727 Biomuta DOID:1319 / brain cancer [ cosmic ]
S839 C839 Biomuta DOID:3571 / liver cancer [ cosmic ]
K951 E951 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K1010 T1010 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1488 L1488 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1493 L1493 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]