iPTMnet Report for Q14997 (PSME4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14997 / PSME4_HUMAN
Protein Name Proteasome activator complex subunit 4
Gene Name Name: PSME4
Synonyms:KIAA0077;
Organism Homo sapiens (Human)

PRO ID PR:Q14997
DAG View
PRO Name proteasome activator complex subunit 4 (human)
Definition A proteasome activator complex subunit 4 that is encoded in the genome of human.
Short Label hPSME4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14997 (PSME4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K36 Ubiquitination PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
T81 Phosphorylation PhosphoSitePlus
Y82 Phosphorylation PhosphoSitePlus
S179 O-Glycosylation GlyGen 30379171, 31492838, 28510447, ...35008409
Y213 Phosphorylation PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus
T338 Phosphorylation PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
T380 O-Glycosylation GlyGen 30379171, 31492838, 28510447, ...35008409
C459 Methylation IEDB 31844290
T572 Phosphorylation PhosphoSitePlus
S580 Phosphorylation PhosphoSitePlus
K636 Ubiquitination PhosphoSitePlus
S642 Phosphorylation PhosphoSitePlus
S883 Phosphorylation PhosphoSitePlus
K908 Ubiquitination PhosphoSitePlus
K916 Ubiquitination PhosphoSitePlus
K922 Ubiquitination PhosphoSitePlus
T952 Phosphorylation PhosphoSitePlus
T954 Phosphorylation PhosphoSitePlus
K1082 Ubiquitination PhosphoSitePlus
Y1087 Phosphorylation PhosphoSitePlus
S1121 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K1124 Ubiquitination PhosphoSitePlus
S1206 Phosphorylation PhosphoSitePlus
K1261 Ubiquitination PhosphoSitePlus
K1294 Ubiquitination PhosphoSitePlus
S1298 Phosphorylation PhosphoSitePlus
T1394 Phosphorylation PhosphoSitePlus
K1397 Acetylation PhosphoSitePlus
T1411 Phosphorylation IEDB   PhosphoSitePlus 27869121
Y1489 Phosphorylation PhosphoSitePlus
K1493 Ubiquitination PhosphoSitePlus
K1572 Ubiquitination PhosphoSitePlus
K1605 Ubiquitination PhosphoSitePlus
S1614 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1615 Phosphorylation PhosphoSitePlus
K1619 Ubiquitination PhosphoSitePlus
S1746 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1753 Phosphorylation PhosphoSitePlus
K1758 Ubiquitination PhosphoSitePlus
K1804 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S642 Phosphorylation HPRD 20068231
S1121 Phosphorylation HPRD 18669648, 19664994


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y82 C82 Biomuta DOID:363 / uterine cancer [ icgc ]
S336 N336 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
T338 A338 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S339 C339 Biomuta DOID:1612 / breast cancer [ icgc ]
S642 F642 Biomuta DOID:4159 / skin cancer [ cosmic ]
K916 T916 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ]
K916 R916 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K922 N922 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T954 S954 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y1087 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K1294 M1294 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1294 T1294 Biomuta DOID:1324 / lung cancer [ cosmic ]
T1394 S1394 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T1394 I1394 Biomuta DOID:1319 / brain cancer [ cosmic ]
K1619 N1619 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]