Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14974 / IMB1_HUMAN
Protein Name Importin subunit beta-1
Gene Name Name: KPNB1
Synonyms:NTF97;
Organism Homo sapiens (Human)

PRO ID PR:Q14974
DAG View
PRO Name importin subunit beta-1 (human)
Definition An importin subunit beta-1 that is encoded in the genome of human.
Short Label hKPNB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14974 (KPNB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378, 22223895, ...25944712
T5 Phosphorylation PhosphoSitePlus
T10 Phosphorylation PhosphoSitePlus
S12 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
R15 Methylation PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
Y76 Phosphorylation PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
T175 Phosphorylation PhosphoSitePlus
K191 Acetylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K211 Acetylation PhosphoSitePlus   UniProt 19608861
K211 Ubiquitination PhosphoSitePlus
T226 Phosphorylation PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
K376 Acetylation PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
Y448 Phosphorylation PhosphoSitePlus
S526 Phosphorylation PhosphoSitePlus
S527 Phosphorylation PhosphoSitePlus
Y529 Phosphorylation PhosphoSitePlus
S531 Phosphorylation PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus
K541 Ubiquitination PhosphoSitePlus
K549 Ubiquitination PhosphoSitePlus
T587 Phosphorylation PhosphoSitePlus
K594 Ubiquitination PhosphoSitePlus
S617 Phosphorylation PhosphoSitePlus
S621 Phosphorylation PhosphoSitePlus
Y646 Phosphorylation PhosphoSitePlus
K651 Ubiquitination PhosphoSitePlus
K710 Ubiquitination PhosphoSitePlus
K730 Ubiquitination PhosphoSitePlus
T738 Phosphorylation PhosphoSitePlus
S743 Phosphorylation PhosphoSitePlus
S750 Phosphorylation PhosphoSitePlus
Y752 Phosphorylation PhosphoSitePlus
Y757 Phosphorylation PhosphoSitePlus
K777 Ubiquitination PhosphoSitePlus
K835 Acetylation PhosphoSitePlus   UniProt 19608861
K835 Ubiquitination PhosphoSitePlus
S853 Phosphorylation PhosphoSitePlus
T855 Phosphorylation PhosphoSitePlus
K859 Ubiquitination PhosphoSitePlus
K867 Acetylation PhosphoSitePlus   UniProt 19608861
K867 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T5 Phosphorylation HPRD 20068231
T10 Phosphorylation HPRD 20068231
S12 Phosphorylation HPRD 18691976, 18669648, 20068231
S170 Phosphorylation HPRD 20068231
S853 Phosphorylation HPRD 20068230
T855 Phosphorylation HPRD 20068230


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R15 G15 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S170 T170 Biomuta DOID:363 / uterine cancer [ tcga ]
S170 C170 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y529 C529 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K710 N710 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T738 A738 Biomuta DOID:1324 / lung cancer [ tcga ]
S750 L750 Biomuta DOID:1324 / lung cancer [ tcga ]
Y757 C757 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S853 L853 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:0070003 / blastoma [ cosmic ]