iPTMnet Report for Q14847 (LASP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14847 / LASP1_HUMAN
Protein Name LIM and SH3 domain protein 1
Gene Name Name: LASP1
Synonyms:MLN50;
Organism Homo sapiens (Human)

PRO ID PR:Q14847
DAG View
PRO Name LIM and SH3 domain protein 1 (human)
Definition A LIM and SH3 domain protein 1 that is encoded in the genome of human.
Short Label hLASP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14847 (LASP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 12665801
K10 Ubiquitination PhosphoSitePlus
Y13 Phosphorylation PhosphoSitePlus
K17 Acetylation PhosphoSitePlus
K17 Ubiquitination PhosphoSitePlus
C20 Methylation IEDB 31844290
K23 Acetylation PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
T34 Phosphorylation PhosphoSitePlus
K36 Acetylation PhosphoSitePlus
T38 Phosphorylation PhosphoSitePlus
K42 Acetylation PhosphoSitePlus   UniProt 19608861
K42 Ubiquitination PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
Y47 Phosphorylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
Y52 Phosphorylation PhosphoSitePlus
Y57 Phosphorylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
S61 O-Glycosylation GlyGen 31373491
S61 Phosphorylation PhosphoSitePlus
T63 Phosphorylation PhosphoSitePlus
T68 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
K75 Methylation PhosphoSitePlus   UniProt 24129315
K75 Sumoylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
Y86 Phosphorylation PhosphoSitePlus
K87 Sumoylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
K92 Acetylation PhosphoSitePlus
K92 Methylation PhosphoSitePlus
K96 Acetylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
S99 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus   UniProt 23186163, 12432067
T104 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 19690332, ...20068231, 17924679
K112 Ubiquitination PhosphoSitePlus
T113 O-Glycosylation GlyGen 33214551, 34725712, 35132862, ...28657654, 35254053, 34019948, 29485866, 29351928, 31373491
T113 Phosphorylation PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus   UniProt 20068231
K121 Acetylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
Y122 Phosphorylation PhosphoSitePlus
K128 Acetylation PhosphoSitePlus
K128 Methylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus   UniProt 23186163
S146 Phosphorylation P17612 (PRKACA) , P05771 (PRKCB) , Q13976 (PRKG1) , Q13237 (PRKG2) , P50613 (CDK7) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 32075106, 18088087, 12571245, ...22665060, 18669648, 24275569, 23186163, 12432067, 20068231
S150 Phosphorylation PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
Y152 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T166 O-Glycosylation GlyGen 33214551, 34725712, 35132862, ...28657654, 35254053, 34019948, 29485866, 29351928, 31373491
T166 Phosphorylation PhosphoSitePlus
S167 O-Glycosylation GlyGen 33214551, 34725712, 35132862, ...28657654, 35254053, 34019948, 29485866, 29351928, 31373491
S167 Phosphorylation PhosphoSitePlus
Y171 Phosphorylation P12931 (SRC) , P00519 (ABL1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 19718473, 15138294, 32075106, ...16094384
S182 O-Glycosylation GlyGen 33214551, 34725712, 35132862, ...28657654, 35254053, 34019948, 29485866, 29351928, 31373491
S182 Phosphorylation PhosphoSitePlus
Y183 Phosphorylation PhosphoSitePlus
Y186 Phosphorylation PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
S194 O-Glycosylation GlyGen 33214551, 34725712, 35132862, ...28657654, 35254053, 34019948, 29485866, 29351928, 31373491
S194 Phosphorylation PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
K205 Acetylation PhosphoSitePlus
Y241 Phosphorylation PhosphoSitePlus
T247 Phosphorylation PhosphoSitePlus
Y257 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T38 Phosphorylation HPRD 20068231
S61 Phosphorylation Q13237 (PRKG2) HPRD 12571245
T63 Phosphorylation HPRD 20068231
T68 Phosphorylation HPRD 17322306, 18669648, 19664995, ...20068231, 17924679
S99 Phosphorylation P31323 (PRKAR2B) HPRD 12432067, 20068231
T104 Phosphorylation HPRD 18212344, 19664994, 19664995, ...18452278, 17322306, 18669648, 19415658, 20068231, 17924679
S118 Phosphorylation HPRD 20068231
Y122 Phosphorylation HPRD 17016520
S134 Phosphorylation HPRD 19651622
S146 Phosphorylation P50613 (CDK7) , Q13237 (PRKG2) , P31323 (PRKAR2B) HPRD 17287340, 18212344, 12571245, ...18077418, 18669648, 20166139, 18088087, 20068231
S150 Phosphorylation HPRD 20068231
S151 Phosphorylation HPRD 20068231, 17924679
Y152 Phosphorylation HPRD 18669648
Y171 Phosphorylation HPRD 16094384


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q14847 (LASP1) S146 Q9UDY2 (TJP2) unknown eFIP 22665060
Phosphorylation Q14847 (LASP1) S146 P61073 (CXCR4) unknown eFIP 32075106


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K17 M17 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
C20 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K42 N42 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y52 C52 Biomuta [ cosmic ] DOID:1612 / breast cancer [ icgc ]
T63 S63 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S99 I99 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K112 E112 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S134 R134 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]