Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14839 / CHD4_HUMAN
Protein Name Chromodomain-helicase-DNA-binding protein 4
Gene Name Name: CHD4
Organism Homo sapiens (Human)

PRO ID PR:Q14839
DAG View
PRO Name chromodomain-helicase-DNA-binding protein 4 (human)
Definition A chromodomain-helicase-DNA-binding protein 4 that is encoded in the genome of human.
Short Label hCHD4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14839 (CHD4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation RLIMS-P 27779108
S27 Phosphorylation PhosphoSitePlus
S44 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 20068231
T46 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
S86 Phosphorylation PhosphoSitePlus
S103 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S105 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S108 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y110 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K115 Acetylation PhosphoSitePlus
K116 Acetylation PhosphoSitePlus
K118 Acetylation PhosphoSitePlus
K119 Acetylation PhosphoSitePlus
K123 Acetylation PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
K273 Acetylation PhosphoSitePlus
K275 Acetylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
K285 Acetylation PhosphoSitePlus
K297 Acetylation PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
K304 Acetylation PhosphoSitePlus
K304 Ubiquitination PhosphoSitePlus
S308 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18669648, 17081983
S309 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 17081983
S310 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 17081983
S319 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 17081983
S325 Phosphorylation PhosphoSitePlus
T360 Phosphorylation PhosphoSitePlus
Y365 Phosphorylation PhosphoSitePlus
T367 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y372 Phosphorylation PhosphoSitePlus
S428 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18669648, 17081983
K499 Ubiquitination PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus
S515 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 17081983, ...24275569
T517 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 17081983
T529 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18847512
S531 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 24275569, ...18847512
K533 Ubiquitination PhosphoSitePlus
S585 Phosphorylation PhosphoSitePlus
K594 Ubiquitination PhosphoSitePlus
K604 Ubiquitination PhosphoSitePlus
K618 Sumoylation PhosphoSitePlus
K618 Ubiquitination PhosphoSitePlus
S631 Phosphorylation PhosphoSitePlus
K634 Ubiquitination PhosphoSitePlus
K635 Ubiquitination PhosphoSitePlus
K668 Ubiquitination PhosphoSitePlus
R679 Methylation PhosphoSitePlus
K696 Ubiquitination PhosphoSitePlus
T703 Phosphorylation PhosphoSitePlus   UniProt 23186163
T705 Phosphorylation PhosphoSitePlus
T709 Phosphorylation PhosphoSitePlus
K711 Sumoylation PhosphoSitePlus
K711 Ubiquitination PhosphoSitePlus
K832 Ubiquitination PhosphoSitePlus
K884 Acetylation PhosphoSitePlus
K884 Ubiquitination PhosphoSitePlus
K959 Ubiquitination PhosphoSitePlus
K964 Ubiquitination PhosphoSitePlus
S979 Phosphorylation PhosphoSitePlus
K987 Acetylation PhosphoSitePlus
K987 Ubiquitination PhosphoSitePlus
R1000 Methylation PhosphoSitePlus
S1007 Phosphorylation PhosphoSitePlus
K1016 Acetylation PhosphoSitePlus
K1016 Ubiquitination PhosphoSitePlus
K1017 Acetylation PhosphoSitePlus
K1017 Ubiquitination PhosphoSitePlus
K1051 Ubiquitination PhosphoSitePlus
K1057 Ubiquitination PhosphoSitePlus
S1073 Phosphorylation PhosphoSitePlus
K1092 Ubiquitination PhosphoSitePlus
K1206 Ubiquitination PhosphoSitePlus
T1207 Phosphorylation PhosphoSitePlus
S1209 Phosphorylation PhosphoSitePlus
K1212 Ubiquitination PhosphoSitePlus
K1220 Ubiquitination PhosphoSitePlus
K1228 Sumoylation PhosphoSitePlus
K1228 Ubiquitination PhosphoSitePlus
S1244 Phosphorylation PhosphoSitePlus
S1245 Phosphorylation PhosphoSitePlus
K1252 Ubiquitination PhosphoSitePlus
T1265 Phosphorylation PhosphoSitePlus
Y1276 Phosphorylation PhosphoSitePlus
K1281 Ubiquitination PhosphoSitePlus
R1288 Methylation PhosphoSitePlus
K1304 Sumoylation PhosphoSitePlus
K1304 Ubiquitination PhosphoSitePlus
S1308 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1313 Phosphorylation PhosphoSitePlus
K1316 Ubiquitination PhosphoSitePlus
R1319 Methylation PhosphoSitePlus
K1335 Ubiquitination PhosphoSitePlus
S1349 Phosphorylation Q13315 (ATM) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17525332, 21219611
S1370 Phosphorylation PhosphoSitePlus
K1390 Ubiquitination PhosphoSitePlus
K1396 Ubiquitination PhosphoSitePlus
K1398 Sumoylation PhosphoSitePlus
K1398 Ubiquitination PhosphoSitePlus
K1422 Ubiquitination PhosphoSitePlus
S1500 Phosphorylation PhosphoSitePlus
K1505 Ubiquitination PhosphoSitePlus
K1528 Ubiquitination PhosphoSitePlus
K1529 Sumoylation PhosphoSitePlus
S1531 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 20068231
S1535 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 18669648, 24275569, 20068231
S1537 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 21406692, 23186163
T1540 Phosphorylation PhosphoSitePlus
T1542 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1544 Phosphorylation PhosphoSitePlus
T1545 Phosphorylation PhosphoSitePlus
T1549 Phosphorylation PhosphoSitePlus
T1553 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
K1565 Sumoylation PhosphoSitePlus
S1570 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K1572 Sumoylation PhosphoSitePlus
K1572 Ubiquitination PhosphoSitePlus
S1576 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K1584 Ubiquitination PhosphoSitePlus
C1594 S-Nitrosylation dbSNO 26338901
T1595 Phosphorylation PhosphoSitePlus
S1602 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 21406692, 15302935
K1643 Acetylation PhosphoSitePlus   UniProt 19608861
K1643 Ubiquitination PhosphoSitePlus
K1647 Sumoylation PhosphoSitePlus
K1647 Ubiquitination PhosphoSitePlus
S1648 Phosphorylation PhosphoSitePlus
T1653 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231, 24275569
K1660 Ubiquitination PhosphoSitePlus
K1670 Sumoylation PhosphoSitePlus
T1679 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
T1722 Phosphorylation PhosphoSitePlus
K1724 Ubiquitination PhosphoSitePlus
T1725 Phosphorylation PhosphoSitePlus
K1766 Ubiquitination PhosphoSitePlus
Y1804 Phosphorylation PhosphoSitePlus
S1808 Phosphorylation PhosphoSitePlus
C1827 S-Nitrosylation dbSNO 26338901
S1831 Phosphorylation PhosphoSitePlus
K1837 Ubiquitination PhosphoSitePlus
S1839 Phosphorylation PhosphoSitePlus
K1844 Ubiquitination PhosphoSitePlus
K1852 Ubiquitination PhosphoSitePlus
K1855 Ubiquitination PhosphoSitePlus
K1865 Ubiquitination PhosphoSitePlus
S1888 Phosphorylation PhosphoSitePlus
T1904 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S44 Phosphorylation HPRD 20068231
T46 Phosphorylation HPRD 17081983
S85 Phosphorylation HPRD 18452278
S86 Phosphorylation HPRD 18452278
S103 Phosphorylation HPRD 15302935, 18452278
S105 Phosphorylation HPRD 18669648, 18452278
S108 Phosphorylation HPRD 18669648, 18452278
Y110 Phosphorylation HPRD 18669648
S308 Phosphorylation HPRD 19651622, 17081983, 20068231, ...18452278
S309 Phosphorylation HPRD 19651622, 17081983, 20068231
S310 Phosphorylation HPRD 19651622, 17081983, 20068231, ...18452278
S319 Phosphorylation HPRD 17081983, 20068231
S325 Phosphorylation HPRD 17081983
S328 Phosphorylation HPRD 17081983
Y329 Phosphorylation HPRD 17081983
S330 Phosphorylation HPRD 17081983
S332 Phosphorylation HPRD 17081983
S335 Phosphorylation HPRD 17081983
T336 Phosphorylation HPRD 17081983
S337 Phosphorylation HPRD 17081983
S428 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S515 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
T517 Phosphorylation HPRD 18669648, 17081983, 20068231
T529 Phosphorylation HPRD 18669648, 20068231
S531 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S585 Phosphorylation HPRD 18452278
Y1091 Phosphorylation HPRD 18767875
S1308 Phosphorylation HPRD 20068231
S1349 Phosphorylation HPRD 17525332
S1360 Phosphorylation HPRD 18452278
S1364 Phosphorylation HPRD 18452278
S1370 Phosphorylation HPRD 19007248, 18452278
S1500 Phosphorylation HPRD 20068231
S1531 Phosphorylation HPRD 19413330, 19651622, 17081983, ...20068231
S1535 Phosphorylation HPRD 19413330, 20058876, 15302935, ...19664995, 19651622, 18669648, 19415658, 20068231, 20068230
S1537 Phosphorylation HPRD 19651622, 15302935, 19415658, ...20068231, 19664995
T1540 Phosphorylation HPRD 19651622
T1542 Phosphorylation HPRD 18669648
T1549 Phosphorylation HPRD 19413330, 18077418, 19664995, ...20068231
T1553 Phosphorylation HPRD 19413330, 18077418
S1570 Phosphorylation HPRD 18669648, 18452278
S1576 Phosphorylation HPRD 18669648
S1602 Phosphorylation HPRD 19413330, 15302935, 19664994
T1653 Phosphorylation HPRD 19664994, 20068231
T1679 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S108 N108 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
Y110 C110 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
K119 N119 Biomuta DOID:263 / kidney cancer [ cosmic ]
K195 N195 Biomuta DOID:363 / uterine cancer [ tcga ]
S277 N277 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S328 R328 Biomuta DOID:3571 / liver cancer [ icgc ]
Y329 * Biomuta DOID:9256 / colorectal cancer [ tcga ]
S330 Y330 Biomuta DOID:363 / uterine cancer [ tcga ]
S428 * Biomuta DOID:363 / uterine cancer [ tcga ]
K618 N618 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S631 R631 Biomuta DOID:1612 / breast cancer [ cosmic ]
K634 N634 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K668 R668 Biomuta DOID:1324 / lung cancer [ cosmic ]
T703 M703 Biomuta DOID:263 / kidney cancer [ cosmic, tcga ]
T705 I705 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R1000 P1000 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S1007 F1007 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
K1016 N1016 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K1051 R1051 Biomuta DOID:1909 / melanoma [ cosmic ]
K1051 T1051 Biomuta DOID:2394 / ovarian cancer [ tcga ]
S1073 P1073 Biomuta DOID:1909 / melanoma [ cosmic ]
T1207 I1207 Biomuta DOID:1909 / melanoma [ tcga ]
K1220 N1220 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K1220 R1220 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S1245 R1245 Biomuta DOID:2531 / hematologic cancer [ icgc ]
R1288 W1288 Biomuta DOID:363 / uterine cancer [ tcga ]
K1316 * Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
R1319 Q1319 Biomuta DOID:363 / uterine cancer [ tcga ]
R1319 W1319 Biomuta DOID:0070003 / blastoma [ cosmic ]
K1335 N1335 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S1364 F1364 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S1370 L1370 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S1535 L1535 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
S1602 L1602 Biomuta DOID:1324 / lung cancer [ tcga ]
S1602 P1602 Biomuta DOID:1324 / lung cancer [ tcga ]
K1724 Q1724 Biomuta DOID:363 / uterine cancer [ tcga ]
S1808 * Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S1808 P1808 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S1839 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]