iPTMnet Report for Q14814 (MEF2D)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14814 / MEF2D_HUMAN
Protein Name Myocyte-specific enhancer factor 2D
Gene Name Name: MEF2D
Organism Homo sapiens (Human)

PRO ID PR:Q14814
DAG View
PRO Name myocyte-specific enhancer factor 2D (human)
Definition A myocyte-specific enhancer factor 2D that is encoded in the genome of human.
Short Label hMEF2D
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14814 (MEF2D) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T20 Phosphorylation RLIMS-P 27487157
K23 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
S98 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 25733682
S98 Phosphorylation P11802 (CDK4) PhosphoSitePlus 25733682
S106 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S110 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 25733682
S110 Phosphorylation P11802 (CDK4) PhosphoSitePlus 25733682
Y117 Phosphorylation PhosphoSitePlus
S121 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 18220336, 10617605, ...18299387, 18669648, 27551452
S121 Phosphorylation P17612 (PRKACA) neXtProt 18299387
S133 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...28314751, 35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 31492838, 29485866, 21158410, 29351928, 35289036, 29237092, 20068230
T134 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...28314751, 35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 31492838, 29485866, 21158410, 29351928, 35289036, 29237092, 20068230
T145 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...28314751, 35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 31492838, 29485866, 21158410, 29351928, 35289036, 29237092, 20068230
S149 O-Glycosylation GlyGen   IEDB 23301498, 34846842, 33214551, ...28314751, 35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 31492838, 29485866, 21158410, 29351928, 35289036, 29237092, 20068230
S153 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...28314751, 35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 31492838, 29485866, 21158410, 29351928, 35289036, 29237092, 20068230
S157 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...28314751, 35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 31492838, 29485866, 21158410, 29351928, 35289036, 29237092, 20068230
S160 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...28314751, 35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 31492838, 29485866, 21158410, 29351928, 35289036, 29237092, 20068230
S162 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...28314751, 35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 31492838, 29485866, 21158410, 29351928, 35289036, 29237092, 20068230
T165 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...28314751, 35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 31492838, 29485866, 21158410, 29351928, 35289036, 29237092, 20068230
S180 Phosphorylation IEDB   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18691976, 23186163, 16964243, ...10849446, 18669648, 32387766, 20068231
S180 Phosphorylation Q13164 (MAPK7) neXtProt   Signor 10849446
S190 Phosphorylation neXtProt   RLIMS-P 27551452, 18299387
S190 Phosphorylation P17612 (PRKACA) neXtProt 18299387
S192 Phosphorylation PhosphoSitePlus
S201 Phosphorylation IEDB   PhosphoSitePlus 27920218, 33936100, 11120772
S212 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S219 Phosphorylation PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
S231 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S242 Phosphorylation PhosphoSitePlus
K245 Acetylation PhosphoSitePlus   UniProt 19608861
K250 Ubiquitination PhosphoSitePlus
S251 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...28314751, 35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 31492838, 29485866, 21158410, 29351928, 35289036, 29237092, 20068230
S251 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 34109727, 23186163, ...24275569
T256 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...28314751, 35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 31492838, 29485866, 21158410, 29351928, 35289036, 29237092, 20068230
T256 Phosphorylation PhosphoSitePlus
S258 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...28314751, 35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 31492838, 29485866, 21158410, 29351928, 35289036, 29237092, 20068230
T259 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...28314751, 35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 31492838, 29485866, 21158410, 29351928, 35289036, 29237092, 20068230
S265 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...28314751, 35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 31492838, 29485866, 21158410, 29351928, 35289036, 29237092, 20068230
K267 Methylation PhosphoSitePlus
T274 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...28314751, 35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 31492838, 29485866, 21158410, 29351928, 35289036, 29237092, 20068230
S275 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 34846842, 33214551, ...28314751, 35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 31492838, 29485866, 21158410, 29351928, 35289036, 29237092, 20068230
S275 Phosphorylation PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
S345 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...28314751, 35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 31492838, 29485866, 21158410, 29351928, 35289036, 29237092, 20068230
S411 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...28314751, 35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 31492838, 29485866, 21158410, 29351928, 35289036, 29237092, 20068230
K439 Acetylation UniProt 16166628
K439 Sumoylation PhosphoSitePlus
S444 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 16356933, 12691662, 19812325, ...15888658
S444 Phosphorylation Q00535 (CDK5) neXtProt   PhosphoSitePlus 16356933, 19812325
S446 Phosphorylation PhosphoSitePlus
S450 Phosphorylation IEDB   PhosphoSitePlus 33936100
S471 Phosphorylation PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus
K511 Acetylation PhosphoSitePlus
T517 Phosphorylation PhosphoSitePlus   RLIMS-P 27487157
K521 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S98 Phosphorylation HPRD 18669648, 18491316, 17081983
S106 Phosphorylation HPRD 18669648, 18491316, 17081983
S110 Phosphorylation HPRD 18669648, 17081983
Y117 Phosphorylation HPRD 18491316
S121 Phosphorylation HPRD 19651622, 18669648, 18212344, ...18452278
S180 Phosphorylation HPRD 18691976, 10849446, 18669648, ...20068231, 18767875
S180 Phosphorylation Q13164 (MAPK7) HPRD 18691976, 10849446, 18669648, ...20068231, 18767875
S192 Phosphorylation HPRD 19664994
S212 Phosphorylation HPRD 15302935
S231 Phosphorylation HPRD 19651622, 18669648, 18212344
S251 Phosphorylation HPRD 19413330, 19651622, 18669648
T517 Phosphorylation HPRD 18212344


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S106 P106 Biomuta DOID:4159 / skin cancer [ cosmic ]
S153 L153 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S180 C180 Biomuta DOID:4159 / skin cancer [ cosmic ]
S227 G227 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S258 R258 Biomuta DOID:3571 / liver cancer [ cosmic ]
S275 Y275 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S508 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]