iPTMnet Report for Q14807 (KIF22)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14807 / KIF22_HUMAN
Protein Name Kinesin-like protein KIF22
Gene Name Name: KIF22
Synonyms:KID,KNSL4;
Organism Homo sapiens (Human)

PRO ID PR:Q14807
DAG View
PRO Name kinesin-like protein KIF22 (human)
Definition A kinesin-like protein KIF22 that is encoded in the genome of human.
Short Label hKIF22
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14807 (KIF22) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R12 Methylation PhosphoSitePlus
R27 Methylation PhosphoSitePlus
K32 Sumoylation PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
T36 Phosphorylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
R97 Methylation PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
T134 Phosphorylation PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
T158 Phosphorylation PhosphoSitePlus   RLIMS-P 35730929
K213 Ubiquitination PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
K287 Methylation PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
K387 Sumoylation PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
K400 Sumoylation PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
S412 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
S421 Phosphorylation PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
S427 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 12727876, 18669648, 23186163, ...19690332
S427 Phosphorylation P06493 (CDK1) PhosphoSitePlus 12727876
K431 Ubiquitination PhosphoSitePlus
S433 O-Glycosylation GlyGen 30379171
S434 Phosphorylation PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus
S452 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332
S455 Phosphorylation PhosphoSitePlus
S462 Phosphorylation PhosphoSitePlus 18847512
S462 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
T463 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12727876, 18847512
T463 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor 12727876
T463 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
K465 Acetylation PhosphoSitePlus
K465 Sumoylation PhosphoSitePlus
K465 Ubiquitination PhosphoSitePlus
K473 Ubiquitination PhosphoSitePlus
K478 Ubiquitination PhosphoSitePlus
K495 Ubiquitination PhosphoSitePlus
K500 Sumoylation PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus
C508 Methylation IEDB 31844290
K524 Ubiquitination PhosphoSitePlus
K528 Ubiquitination PhosphoSitePlus
S543 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 20068231, 16565220
K552 Ubiquitination PhosphoSitePlus
K559 Sumoylation PhosphoSitePlus
K559 Ubiquitination PhosphoSitePlus
S562 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 20068231, 16565220
S581 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 20068231, 16565220
K591 Ubiquitination PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
K643 Ubiquitination PhosphoSitePlus
K650 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation HPRD 20068231
S23 Phosphorylation HPRD 20068231
S31 Phosphorylation HPRD 20068231
T158 Phosphorylation HPRD 20068231
S412 Phosphorylation HPRD 18669648, 19007248, 20068231, ...19691289
S427 Phosphorylation HPRD 12727876, 18669648, 19007248, ...20068231, 18452278
S452 Phosphorylation HPRD 17525332, 20068231
S455 Phosphorylation HPRD 20068231
S462 Phosphorylation HPRD 19691289, 20068231
T463 Phosphorylation HPRD 19664995, 20068231, 19691289
S543 Phosphorylation HPRD 19007248, 20068231, 16565220
S562 Phosphorylation HPRD 19691289, 20068231, 16565220
S581 Phosphorylation HPRD 20068231, 16565220


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R27 C27 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
K32 N32 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S140 N140 Biomuta [ cosmic ]
S140 R140 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S357 C357 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K387 N387 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S445 C445 Biomuta DOID:263 / kidney cancer [ cosmic ]
S445 N445 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T463 I463 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K478 N478 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K504 E504 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K650 Q650 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]