iPTMnet Report for Q14790 (CASP8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q14790 / CASP8_HUMAN
Protein Name Caspase-8 precursor
Gene Name Name: CASP8
Synonyms:MCH5;
Organism Homo sapiens (Human)

PRO ID PR:Q14790
DAG View
PRO Name caspase-8 (human)
Definition A caspase-8 that is encoded in the genome of human.
Short Label hCASP8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q14790 (CASP8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
K156 Sumoylation PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
Y178 Phosphorylation PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
S219 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
K224 Ubiquitination PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
Y235 Phosphorylation PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
T263 Phosphorylation P51812 (RPS6KA3) neXtProt   PhosphoSitePlus   RLIMS-P 21183680
T273 Phosphorylation PhosphoSitePlus   RLIMS-P 27462786, 27325299, 28405521
S305 Phosphorylation PhosphoSitePlus
Y334 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455
K344 Ubiquitination PhosphoSitePlus
S347 Phosphorylation Q16539 (MAPK14) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 14970175
K351 Ubiquitination PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
T373 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus
Y380 Phosphorylation P07948 (LYN) , P12931 (SRC) neXtProt   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor 36460775, 30501030, 34367939, ...27432652, 27821809, 24100030, 18089778, 16619028, 27109099, 19851329, 27195913, 18086677
S387 Phosphorylation P06493 (CDK1) , P27361 (MAPK3) , P28482 (MAPK1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 26036637, 20937773, 25790448, ...24342355
Y448 Phosphorylation P07948 (LYN) PhosphoSitePlus 18086677
K461 Ubiquitination PhosphoSitePlus
K473 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S217 Phosphorylation HPRD 20068231
S219 Phosphorylation HPRD 17525332
S230 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S202 Phosphorylation HPRD 20068231
S204 Phosphorylation HPRD 17525332
S215 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
Y8 Phosphorylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
S234 Phosphorylation HPRD 20068231
S236 Phosphorylation HPRD 17525332
Y243 Phosphorylation PhosphoSitePlus
S247 Phosphorylation HPRD 20068231
Y351 Phosphorylation PhosphoSitePlus
Y397 Phosphorylation PhosphoSitePlus
Y465 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K208 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K183 Ubiquitination PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y52 Phosphorylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
S276 Phosphorylation HPRD 20068231
S278 Phosphorylation HPRD 17525332
S289 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y8 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K23 E23 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K39 N39 Biomuta DOID:4362 / cervical cancer [ icgc ]
K63 T63 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S113 R113 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K121 T121 Biomuta DOID:363 / uterine cancer [ icgc ]
K130 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K148 N148 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K148 R148 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K148 T148 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K161 T161 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K169 N169 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y178 C178 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K208 N208 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S209 L209 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S211 C211 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K224 T224 Biomuta DOID:363 / uterine cancer [ icgc ]
S228 C228 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K229 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S230 I230 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S230 N230 Biomuta DOID:1319 / brain cancer [ cosmic ]
Y235 H235 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y243 C243 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y243 F243 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S247 N247 Biomuta DOID:1319 / brain cancer [ cosmic ]
S247 I247 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S289 N289 Biomuta DOID:1319 / brain cancer [ cosmic ]
S289 I289 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y334 C334 Biomuta DOID:1612 / breast cancer [ cosmic ]
S347 F347 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]
K351 Q351 Biomuta DOID:363 / uterine cancer [ icgc ]
Y351 C351 Biomuta DOID:1612 / breast cancer [ cosmic ]
K353 N353 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K353 R353 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K353 T353 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S375 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S375 L375 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y380 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
Y397 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
K461 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
K473 I473 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K473 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]